Polygonatone H, a new homoisoflavanone with cytotoxicity from Polygonatum Cyrtonema Hua

Nat Prod Res. 2019 Jun;33(12):1727-1733. doi: 10.1080/14786419.2018.1434645. Epub 2018 Feb 19.

Abstract

A new homoisoflavonoid, (3R)-5,7-dihydroxy-6-methyl-3-(2'-hydroxy-4'-methoxybenzyl)-chroman-4-one (1), namely polygonatone H, in addition to fourteen known homoisoflavones (2-15) were isolated from the rhizome of Polygonatum Cyrtonema Hua. The structures were identified with the aid of 1D/2D NMR spectroscopic technologies. Compounds 2, 6, 8, 10, 11, 13, and 15 were isolated from P. Cyrtonema for the first time. Compound 1 showed cytotoxicities to human cancer cell lines with IC50 values to comparable those of cisplatin.

Keywords: Hua.; cytotoxicity; homoisoflavone.

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / isolation & purification*
  • Antineoplastic Agents / pharmacology
  • Cell Line
  • Cytotoxins / chemistry
  • Cytotoxins / isolation & purification
  • Cytotoxins / pharmacology
  • Humans
  • Inhibitory Concentration 50
  • Isoflavones / chemistry
  • Isoflavones / isolation & purification*
  • Isoflavones / toxicity*
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Polygonatum / chemistry*
  • Rhizome / chemistry*

Substances

  • Antineoplastic Agents
  • Cytotoxins
  • Isoflavones