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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1991 4
1992 1
2000 1
2004 1
2005 1
2006 1
2007 1
2008 2
2009 2
2010 1
2011 1
2012 1
2013 2
2014 2
2015 1
2016 1
2017 1
2018 1
2024 0

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22 results

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Page 1
The essential role of DOCK8 in humoral immunity.
Randall KL, Lambe T, Goodnow CC, Cornall RJ. Randall KL, et al. Dis Markers. 2010;29(3-4):141-50. doi: 10.3233/DMA-2010-0739. Dis Markers. 2010. PMID: 21178273 Free PMC article. Review.
In this review we describe a genome-wide screen in mice for the genes important for generating these adaptive responses, and describe two independent DOCK8 mutant mice strains identified by this screen. DOCK 8 was found to play an essential role in humoral immune responses …
In this review we describe a genome-wide screen in mice for the genes important for generating these adaptive responses, and describe two in …
Themis2 lowers the threshold for B cell activation during positive selection.
Cheng D, Deobagkar-Lele M, Zvezdova E, Choi S, Uehara S, Baup D, Bennett SC, Bull KR, Crockford TL, Ferry H, Warzecha C, Marcellin M, de Peredo AG, Lesourne R, Anzilotti C, Love PE, Cornall RJ. Cheng D, et al. Nat Immunol. 2017 Feb;18(2):205-213. doi: 10.1038/ni.3642. Epub 2016 Dec 19. Nat Immunol. 2017. PMID: 27992403
Spontaneous B cell hyperactivity in autoimmune-prone MRL mice.
Nijnik A, Ferry H, Lewis G, Rapsomaniki E, Leung JC, Daser A, Lambe T, Goodnow CC, Cornall RJ. Nijnik A, et al. Int Immunol. 2006 Jul;18(7):1127-37. doi: 10.1093/intimm/dxl047. Epub 2006 May 30. Int Immunol. 2006. PMID: 16735376
The MRL-lpr/lpr mouse strain is a commonly used model of the human autoimmune disease systemic lupus erythematosus (SLE). ...We conclude that B cell hyperactivity may contribute to the autoimmune phenotype of MRL+/+ and MRL-lpr/lpr strains when it initiates antibody …
The MRL-lpr/lpr mouse strain is a commonly used model of the human autoimmune disease systemic lupus erythematosus (SLE). ...We concl …
Identification of a Steap3 endosomal targeting motif essential for normal iron metabolism.
Lambe T, Simpson RJ, Dawson S, Bouriez-Jones T, Crockford TL, Lepherd M, Latunde-Dada GO, Robinson H, Raja KB, Campagna DR, Villarreal G Jr, Ellory JC, Goodnow CC, Fleming MD, McKie AT, Cornall RJ. Lambe T, et al. Blood. 2009 Feb 19;113(8):1805-8. doi: 10.1182/blood-2007-11-120402. Epub 2008 Oct 27. Blood. 2009. PMID: 18955558 Free PMC article.
To address this limitation, we have developed a screen for heritable abnormalities of red blood cell morphology in mice with single-nucleotide changes induced by the chemical mutagen ethylnitrosourea (ENU). We now describe the first strain, fragile-red, with hypochromic mi …
To address this limitation, we have developed a screen for heritable abnormalities of red blood cell morphology in mice with single-nucleoti …
DOCK8 is essential for T-cell survival and the maintenance of CD8+ T-cell memory.
Lambe T, Crawford G, Johnson AL, Crockford TL, Bouriez-Jones T, Smyth AM, Pham TH, Zhang Q, Freeman AF, Cyster JG, Su HC, Cornall RJ. Lambe T, et al. Eur J Immunol. 2011 Dec;41(12):3423-35. doi: 10.1002/eji.201141759. Epub 2011 Nov 10. Eur J Immunol. 2011. PMID: 21969276 Free PMC article.
Deficiency in the guanine nucleotide exchange factor dedicator of cytokinesis 8 (DOCK8) causes a human immunodeficiency syndrome associated with recurrent sinopulmonary and viral infections. We have recently identified a DOCK8-deficient mouse strain, carrying an ethylnitro …
Deficiency in the guanine nucleotide exchange factor dedicator of cytokinesis 8 (DOCK8) causes a human immunodeficiency syndrome associated …
DNA repair is limiting for haematopoietic stem cells during ageing.
Nijnik A, Woodbine L, Marchetti C, Dawson S, Lambe T, Liu C, Rodrigues NP, Crockford TL, Cabuy E, Vindigni A, Enver T, Bell JI, Slijepcevic P, Goodnow CC, Jeggo PA, Cornall RJ. Nijnik A, et al. Nature. 2007 Jun 7;447(7145):686-90. doi: 10.1038/nature05875. Nature. 2007. PMID: 17554302
Here we address this question by taking advantage of the highly specific role of DNA ligase IV in the repair of DNA double-strand breaks by non-homologous end-joining, and by the discovery of a unique mouse strain with a hypomorphic Lig4(Y288C) mutation. The Lig4(Y288C) mo …
Here we address this question by taking advantage of the highly specific role of DNA ligase IV in the repair of DNA double-strand breaks by …
Sex-dependent competitive dominance of phylogenetic group B2 Escherichia coli strains within human hosts.
Blyton MD, Cornall SJ, Kennedy K, Colligon P, Gordon DM. Blyton MD, et al. Environ Microbiol Rep. 2014 Dec;6(6):605-10. doi: 10.1111/1758-2229.12168. Environ Microbiol Rep. 2014. PMID: 25756113
Female individuals carrying a dominant B2 strain were found to possess fewer strains than those carrying dominant A or B1 strains. Additionally, strains from the same phylogenetic group were more likely to co-occur in females. ...
Female individuals carrying a dominant B2 strain were found to possess fewer strains than those carrying dominant A or B1 s …
Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations.
Bull KR, Rimmer AJ, Siggs OM, Miosge LA, Roots CM, Enders A, Bertram EM, Crockford TL, Whittle B, Potter PK, Simon MM, Mallon AM, Brown SD, Beutler B, Goodnow CC, Lunter G, Cornall RJ. Bull KR, et al. PLoS Genet. 2013;9(1):e1003219. doi: 10.1371/journal.pgen.1003219. Epub 2013 Jan 31. PLoS Genet. 2013. PMID: 23382690 Free PMC article.
In this strategy, we use a modification of the Lander-Green algorithm to isolate causative recessive and dominant mutations, even at low coverage, on a pure strain background. Analysis of the IBD regions also allows us to calculate the ENU mutation rate (1.54 mutations per …
In this strategy, we use a modification of the Lander-Green algorithm to isolate causative recessive and dominant mutations, even at low cov …
22 results