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Temporal metabolic trajectory analyzed by LC-MS/MS based targeted metabolomics in acute pancreatitis pathogenesis and Chaiqin Chengqi decoction therapy.
Huang Y, Wen Y, Wang R, Hu L, Yang J, Yang J, Pu Q, Han C, Cai W, Peng Y, Wang Y, Jiang H, Hong J, Phillips AR, Fu X, Huang W, Xia Q, Du D. Huang Y, et al. Phytomedicine. 2022 May;99:153996. doi: 10.1016/j.phymed.2022.153996. Epub 2022 Feb 17. Phytomedicine. 2022. PMID: 35231826
BACKGROUND: Acute pancreatitis (AP) is an inflammatory disorder of pancreas that lacks effective specific drugs as well as gold standard laboratory tests for diagnosis and severity assessment. Chaiqin chengqi decoction (CQCQD) has been proven to alleviate the severity and …
BACKGROUND: Acute pancreatitis (AP) is an inflammatory disorder of pancreas that lacks effective specific drugs as well as gold standard lab …
TaoHe ChengQi decoction ameliorates sepsis-induced cardiac dysfunction through anti-ferroptosis via the Nrf2 pathway.
Lu SM, Yang B, Tan ZB, Wang HJ, Xie JD, Xie MT, Jiang WH, Huang JZ, Li J, Zhang L, Tan YZ, Zhang JZ, Liu B, Wu WW, Zhang SW. Lu SM, et al. Phytomedicine. 2024 Apr 20;129:155597. doi: 10.1016/j.phymed.2024.155597. Online ahead of print. Phytomedicine. 2024. PMID: 38643713
BACKGROUND: Sepsis-induced cardiac dysfunction (SICD) is a serious complication of sepsis that is associated with increased mortality. Ferroptosis has been reported in the SICD. TaoHe ChengQi decoction (THCQD), a classical traditional Chinese medicinal formula, has multipl …
BACKGROUND: Sepsis-induced cardiac dysfunction (SICD) is a serious complication of sepsis that is associated with increased mortality. Ferro …
Modified Da Chengqi granules improvement in immune function in early severe acute pancreatitis patients.
Jiang DL, Yang J, Jiang SY, Yuan FL, Gu YL, Li JP, Pei ZJ. Jiang DL, et al. Genet Mol Res. 2016 Jun 24;15(2). doi: 10.4238/gmr.15028787. Genet Mol Res. 2016. PMID: 27420976 Free article. Clinical Trial.

We investigated the role of modified Da Chengqi granules in improving immune function in early severe acute pancreatitis patients. ...Significant differences in Treg levels and Th1/Th2 cell ratio between experimental and control groups were observed on day 14 (P < 0.01)

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We investigated the role of modified Da Chengqi granules in improving immune function in early severe acute pancreatitis patients. .. …
AGI grade-guided chaiqin chengqi decoction treatment for predicted moderately severe and severe acute pancreatitis (CAP trial): study protocol of a randomised, double-blind, placebo-controlled, parallel-group, pragmatic clinical trial.
Chen Z, Yang X, Guo J, Jin T, Lin Z, Zhu P, Li J, Li L, Sun X, Du D, Jiang K, He Y, Cai F, Li L, Hu C, Tan Q, Huang W, Deng L, Xia Q. Chen Z, et al. Trials. 2022 Nov 8;23(1):933. doi: 10.1186/s13063-022-06792-x. Trials. 2022. PMID: 36348365 Free PMC article.
Moderately severe and severe acute pancreatitis (MSAP/SAP) contributes predominately for its morbidities and mortality and has been managed in West China Hospital for decades using the traditional Chinese medicinal formula chaiqin chengqi decoction (CQCQD). The current stu …
Moderately severe and severe acute pancreatitis (MSAP/SAP) contributes predominately for its morbidities and mortality and has been managed …
Chaiqin chengqi decoction ameliorates acute pancreatitis in mice via inhibition of neuron activation-mediated acinar cell SP/NK1R signaling pathways.
Han C, Du D, Wen Y, Li J, Wang R, Jin T, Yang J, Shi N, Jiang K, Deng L, Fu X, Mukherjee R, Windsor JA, Hong J, Phillips AR, Sutton R, Huang W, Liu T, Xia Q. Han C, et al. J Ethnopharmacol. 2021 Jun 28;274:114029. doi: 10.1016/j.jep.2021.114029. Epub 2021 Mar 14. J Ethnopharmacol. 2021. PMID: 33731310 Free article.
ETHNOPHARMACOLOGICAL RELEVANCE: Chaiqin chengqi decoction (CQCQD) and its derivatives have been widely used in China for the early management of patients with acute pancreatitis (AP). ...
ETHNOPHARMACOLOGICAL RELEVANCE: Chaiqin chengqi decoction (CQCQD) and its derivatives have been widely used in China for the early ma …
Improving Small Intestinal Motility in Experimental Acute Necrotising Pancreatitis by Modulating the CPI-17/MLCP Pathway Using Chaiqin Chengqi Decoction.
Lin Z, Zhang C, Zhang X, Shi N, Wen Y, Han C, Du D, Liu T, Jin T, Deng L, Jiang K, Yang X, Guo J, Philips A, Sutton R, Windsor JA, Huang W, Xue P, Xia Q. Lin Z, et al. Evid Based Complement Alternat Med. 2020 Feb 10;2020:9189457. doi: 10.1155/2020/9189457. eCollection 2020. Evid Based Complement Alternat Med. 2020. PMID: 32104199 Free PMC article. Retracted.
Protein kinase C-potentiated inhibitor protein of 17 kDa (CPI-17), a specific inhibitor of myosin light-chain phosphatase (MLCP) regulated by proinflammatory cytokines, is central for calcium sensitisation. We investigated the effects of chaiqin chengqi decoction (CQCQD) o …
Protein kinase C-potentiated inhibitor protein of 17 kDa (CPI-17), a specific inhibitor of myosin light-chain phosphatase (MLCP) regulated b …