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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 1
1966 1
1969 2
1970 1
1972 3
1975 2
1976 3
1977 12
1978 5
1979 6
1980 15
1981 16
1982 22
1983 31
1984 50
1985 43
1986 41
1987 38
1988 46
1989 37
1990 51
1991 39
1992 32
1993 37
1994 43
1995 28
1996 38
1997 28
1998 41
1999 37
2000 20
2001 35
2002 25
2003 25
2004 23
2005 30
2006 27
2007 37
2008 31
2009 33
2010 43
2011 32
2012 35
2013 34
2014 36
2015 34
2016 34
2017 37
2018 30
2019 25
2020 17
2021 36
2022 33
2023 26
2024 7

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1,435 results

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Page 1
The Pathogenesis of African Trypanosomiasis.
Pays E, Radwanska M, Magez S. Pays E, et al. Annu Rev Pathol. 2023 Jan 24;18:19-45. doi: 10.1146/annurev-pathmechdis-031621-025153. Epub 2022 Sep 2. Annu Rev Pathol. 2023. PMID: 36055769 Free article. Review.
In the two human-infective trypanosomes, specific parasite resistance factors inhibit APOL1 activity. In turn, many African individuals express APOL1 variants that counteract these resistance factors, enabling them to avoid sleeping sickness. However, these variants …
In the two human-infective trypanosomes, specific parasite resistance factors inhibit APOL1 activity. In turn, many African individuals expr …
The glycosylation of the variant surface glycoproteins and procyclic acidic repetitive proteins of Trypanosoma brucei.
Mehlert A, Zitzmann N, Richardson JM, Treumann A, Ferguson MA. Mehlert A, et al. Mol Biochem Parasitol. 1998 Mar 1;91(1):145-52. doi: 10.1016/s0166-6851(97)00187-4. Mol Biochem Parasitol. 1998. PMID: 9574932 Review.
Trypanosoma brucei, in common with the other African trypanosomes, exhibits unusual cell-surface molecular architecture. ...In this article, the structures of the N-glycans and the GPI anchors of T. brucei VSGs and PARPs are reviewed and simple models of the surface …
Trypanosoma brucei, in common with the other African trypanosomes, exhibits unusual cell-surface molecular architecture. ...In this a …
Turnover of Variant Surface Glycoprotein in Trypanosoma brucei Is Not Altered in Response to Specific Silencing.
Sharif M, Garrison P, Bush P, Bangs JD. Sharif M, et al. mSphere. 2022 Aug 31;7(4):e0012222. doi: 10.1128/msphere.00122-22. Epub 2022 Jun 21. mSphere. 2022. PMID: 35727016 Free PMC article.
African trypanosomes evade the immune system of the mammalian host by the antigenic variation of the predominant glycosylphosphatidylinositol (GPI)-anchored surface protein, variant surface glycoprotein (VSG). VSG is a very stable protein that is turned over from the cell …
African trypanosomes evade the immune system of the mammalian host by the antigenic variation of the predominant glycosylphosphatidylinosito …
Structure of the variant glycoproteins and surface coat of Trypanosoma brucei.
Cross GA. Cross GA. Philos Trans R Soc Lond B Biol Sci. 1984 Nov 13;307(1131):3-12. doi: 10.1098/rstb.1984.0104. Philos Trans R Soc Lond B Biol Sci. 1984. PMID: 6151686 Review.
The range of diversity within the thousand or so variant glycoprotein genes that exist in each cell is large. New variants may arise instantaneously by segmental gene conversion. Variant surface glycoproteins are synthesized with amino terminal signal sequenc …
The range of diversity within the thousand or so variant glycoprotein genes that exist in each cell is large. New variants may …
Control and function of the bloodstream variant surface glycoprotein expression sites in Trypanosoma brucei.
Vanhamme L, Lecordier L, Pays E. Vanhamme L, et al. Int J Parasitol. 2001 May 1;31(5-6):523-31. doi: 10.1016/s0020-7519(01)00143-6. Int J Parasitol. 2001. PMID: 11334937 Review.
African trypanosomes escape the host immune response through a periodical change of their surface coat made of one major type of protein, the variant surface glycoprotein. From a repertoire of a thousand variant surface glycoprotein genes available, only one is expr …
African trypanosomes escape the host immune response through a periodical change of their surface coat made of one major type of protein, th …
TbSAP is a novel chromatin protein repressing metacyclic variant surface glycoprotein expression sites in bloodstream form Trypanosoma brucei.
Davies C, Ooi CP, Sioutas G, Hall BS, Sidhu H, Butter F, Alsford S, Wickstead B, Rudenko G. Davies C, et al. Nucleic Acids Res. 2021 Apr 6;49(6):3242-3262. doi: 10.1093/nar/gkab109. Nucleic Acids Res. 2021. PMID: 33660774 Free PMC article.
The African trypanosome Trypanosoma brucei is a unicellular eukaryote, which relies on a protective variant surface glycoprotein (VSG) coat for survival in the mammalian host. ...TbSAP therefore appears to be a novel chromatin protein playing an important role in si …
The African trypanosome Trypanosoma brucei is a unicellular eukaryote, which relies on a protective variant surface glycoprote …
Short tRNA anticodon stem and mutant eRF1 allow stop codon reassignment.
Kachale A, Pavlíková Z, Nenarokova A, Roithová A, Durante IM, Miletínová P, Záhonová K, Nenarokov S, Votýpka J, Horáková E, Ross RL, Yurchenko V, Beznosková P, Paris Z, Valášek LS, Lukeš J. Kachale A, et al. Nature. 2023 Jan;613(7945):751-758. doi: 10.1038/s41586-022-05584-2. Epub 2023 Jan 11. Nature. 2023. PMID: 36631608
The canonical 5-bp tRNA(Trp) recognizes UGG as dictated by the genetic code, whereas its shortened 4-bp variant incorporates tryptophan also into in-frame UGA. Mimicking this evolutionary twist by engineering both variants from B. nonstop, Trypanosoma brucei …
The canonical 5-bp tRNA(Trp) recognizes UGG as dictated by the genetic code, whereas its shortened 4-bp variant incorporates tryptoph …
A Primate APOL1 Variant That Kills Trypanosoma brucei gambiense.
Cooper A, Capewell P, Clucas C, Veitch N, Weir W, Thomson R, Raper J, MacLeod A. Cooper A, et al. PLoS Negl Trop Dis. 2016 Aug 5;10(8):e0004903. doi: 10.1371/journal.pntd.0004903. eCollection 2016 Aug. PLoS Negl Trop Dis. 2016. PMID: 27494254 Free PMC article.
Such variants have been proposed as candidates for developing therapeutic alternatives to the unsatisfactory anti-trypanosomal drugs currently in use. ...The identification of a variant of APOL1 with trypanolytic ability for both human-infective T. brucei sub …
Such variants have been proposed as candidates for developing therapeutic alternatives to the unsatisfactory anti-trypanosomal drugs …
Surface coat variant antigen of Trypanosoma brucei brucei: its clearance from blood and concentration in organs of normal, infected, and immune mice.
Diffley P, Jayawardena AN. Diffley P, et al. Infect Immun. 1982 Jan;35(1):173-8. doi: 10.1128/iai.35.1.173-178.1982. Infect Immun. 1982. PMID: 6119292 Free PMC article.
Experiments were conducted to determine the fate of variant antigen once it was shed from the surface of Trypanosoma brucei brucei. Radioiodinated variant antigen was administered intravenously to normal mice, mice immunized to the homologous varian …
Experiments were conducted to determine the fate of variant antigen once it was shed from the surface of Trypanosoma brucei …
1,435 results