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174 results

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Page 1
Huntington disease: natural history, biomarkers and prospects for therapeutics.
Ross CA, Aylward EH, Wild EJ, Langbehn DR, Long JD, Warner JH, Scahill RI, Leavitt BR, Stout JC, Paulsen JS, Reilmann R, Unschuld PG, Wexler A, Margolis RL, Tabrizi SJ. Ross CA, et al. Nat Rev Neurol. 2014 Apr;10(4):204-16. doi: 10.1038/nrneurol.2014.24. Epub 2014 Mar 11. Nat Rev Neurol. 2014. PMID: 24614516 Free article. Review.
Structural neuroimaging biomarkers show that progressive regional brain atrophy begins many years before the emergence of diagnosable signs and symptoms of HD, and continues steadily during the symptomatic or 'manifest' period. ...
Structural neuroimaging biomarkers show that progressive regional brain atrophy begins many years before the emergence of diagnosable …
The Lancet Commission on the future of care and clinical research in autism.
Lord C, Charman T, Havdahl A, Carbone P, Anagnostou E, Boyd B, Carr T, de Vries PJ, Dissanayake C, Divan G, Freitag CM, Gotelli MM, Kasari C, Knapp M, Mundy P, Plank A, Scahill L, Servili C, Shattuck P, Simonoff E, Singer AT, Slonims V, Wang PP, Ysrraelit MC, Jellett R, Pickles A, Cusack J, Howlin P, Szatmari P, Holbrook A, Toolan C, McCauley JB. Lord C, et al. Lancet. 2022 Jan 15;399(10321):271-334. doi: 10.1016/S0140-6736(21)01541-5. Epub 2021 Dec 6. Lancet. 2022. PMID: 34883054 No abstract available.
Functional Magnetic Resonance Imaging in Huntington's Disease.
Gregory S, Scahill RI. Gregory S, et al. Int Rev Neurobiol. 2018;142:381-408. doi: 10.1016/bs.irn.2018.09.013. Epub 2018 Oct 29. Int Rev Neurobiol. 2018. PMID: 30409260 Review.
However, disease effects on brain function are less well characterized. Functional MRI provides an opportunity to examine differences in brain activity either in response to a particular task or in the brain at rest. There is increasing evidence that HD gene …
However, disease effects on brain function are less well characterized. Functional MRI provides an opportunity to examine differences …
Fluid and imaging biomarkers for Huntington's disease.
Zeun P, Scahill RI, Tabrizi SJ, Wild EJ. Zeun P, et al. Mol Cell Neurosci. 2019 Jun;97:67-80. doi: 10.1016/j.mcn.2019.02.004. Epub 2019 Feb 23. Mol Cell Neurosci. 2019. PMID: 30807825 Review.
Biofluid biomarkers have potential advantages of direct quantification of biological processes at the molecular level, whilst imaging biomarkers can quantify related changes at a structural level in the brain. The most robust biofluid and imaging biomarkers can offer compl …
Biofluid biomarkers have potential advantages of direct quantification of biological processes at the molecular level, whilst imaging biomar …
Diffusion imaging in Huntington's disease: comprehensive review.
Estevez-Fraga C, Scahill R, Rees G, Tabrizi SJ, Gregory S. Estevez-Fraga C, et al. J Neurol Neurosurg Psychiatry. 2020 Oct 8;92(1):62-9. doi: 10.1136/jnnp-2020-324377. Online ahead of print. J Neurol Neurosurg Psychiatry. 2020. PMID: 33033167 Free PMC article. Review.
With the advent of genetic testing in adults, disease-related, structural brain changes can be investigated from the earliest, premorbid stages of HD. ...Multiple approaches, including voxelwise, region of interest and tractography, have been used in HD cohorts, showing a …
With the advent of genetic testing in adults, disease-related, structural brain changes can be investigated from the earliest, premor …
Genetic topography and cortical cell loss in Huntington's disease link development and neurodegeneration.
Estevez-Fraga C, Altmann A, Parker CS, Scahill RI, Costa B, Chen Z, Manzoni C, Zarkali A, Durr A, Roos RAC, Landwehrmeyer B, Leavitt BR, Rees G, Tabrizi SJ, McColgan P. Estevez-Fraga C, et al. Brain. 2023 Nov 2;146(11):4532-4546. doi: 10.1093/brain/awad275. Brain. 2023. PMID: 37587097 Free PMC article.
These maps were combined with gene expression data from the Allen Human Brain Atlas (AHBA) to investigate the biological processes relating genetic topography and cortical cell loss. ...These events result in age-related cell death across multiple brain cell types.. …
These maps were combined with gene expression data from the Allen Human Brain Atlas (AHBA) to investigate the biological processes re …
Structural imaging in premanifest and manifest Huntington disease.
Scahill RI, Andre R, Tabrizi SJ, Aylward EH. Scahill RI, et al. Handb Clin Neurol. 2017;144:247-261. doi: 10.1016/B978-0-12-801893-4.00020-1. Handb Clin Neurol. 2017. PMID: 28947121 Review.
Huntington disease (HD) neuropathology has a devastating effect on brain structure and consequently brain function; neuroimaging provides a means to assess these effects in gene carriers. ...We review the existing literature to summarize what we know so far about st …
Huntington disease (HD) neuropathology has a devastating effect on brain structure and consequently brain function; neuroimagi …
Brain-derived neurotrophic factor in cerebrospinal fluid and plasma is not a biomarker for Huntington's disease.
Ou ZA, Byrne LM, Rodrigues FB, Tortelli R, Johnson EB, Foiani MS, Arridge M, De Vita E, Scahill RI, Heslegrave A, Zetterberg H, Wild EJ. Ou ZA, et al. Sci Rep. 2021 Feb 10;11(1):3481. doi: 10.1038/s41598-021-83000-x. Sci Rep. 2021. PMID: 33568689 Free PMC article.
Brain-derived neurotrophic factor (BDNF) is implicated in the survival of striatal neurons. ...Using the ultra-sensitive method, BDNF concentration was quantifiable in all samples but did not differ between controls and HD mutation carriers in CSF or plasma, was not associ …
Brain-derived neurotrophic factor (BDNF) is implicated in the survival of striatal neurons. ...Using the ultra-sensitive method, BDNF …
Volumetric MRI-Based Biomarkers in Huntington's Disease: An Evidentiary Review.
Kinnunen KM, Schwarz AJ, Turner EC, Pustina D, Gantman EC, Gordon MF, Joules R, Mullin AP, Scahill RI, Georgiou-Karistianis N; Huntington's Disease Regulatory Science Consortium (HD-RSC). Kinnunen KM, et al. Front Neurol. 2021 Sep 21;12:712555. doi: 10.3389/fneur.2021.712555. eCollection 2021. Front Neurol. 2021. PMID: 34621236 Free PMC article. Review.
Neuropathological studies show that disease progression follows a characteristic pattern of brain atrophy, beginning in the basal ganglia structures. The HD Regulatory Science Consortium (HD-RSC) brings together diverse stakeholders in the HD community-biopharmaceutical in …
Neuropathological studies show that disease progression follows a characteristic pattern of brain atrophy, beginning in the basal gan …
174 results