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Page 1
Spatial transcriptomics at subspot resolution with BayesSpace.
Zhao E, Stone MR, Ren X, Guenthoer J, Smythe KS, Pulliam T, Williams SR, Uytingco CR, Taylor SEB, Nghiem P, Bielas JH, Gottardo R. Zhao E, et al. Nat Biotechnol. 2021 Nov;39(11):1375-1384. doi: 10.1038/s41587-021-00935-2. Epub 2021 Jun 3. Nat Biotechnol. 2021. PMID: 34083791 Free PMC article.
We benchmark BayesSpace against current methods for spatial and non-spatial clustering and show that it improves identification of distinct intra-tissue transcriptional profiles from samples of the brain, melanoma, invasive ductal carcinoma and ovarian adenocarcinoma. ...
We benchmark BayesSpace against current methods for spatial and non-spatial clustering and show that it improves identification of distinct …
Bridging Single Neuron Dynamics to Global Brain States.
Goldman JS, Tort-Colet N, di Volo M, Susin E, Bouté J, Dali M, Carlu M, Nghiem TA, Górski T, Destexhe A. Goldman JS, et al. Front Syst Neurosci. 2019 Dec 6;13:75. doi: 10.3389/fnsys.2019.00075. eCollection 2019. Front Syst Neurosci. 2019. PMID: 31866837 Free PMC article.
Biological neural networks produce information backgrounds of multi-scale spontaneous activity that become more complex in brain states displaying higher capacities for cognition, for instance, attentive awake versus asleep or anesthetized states. Here, we review brain …
Biological neural networks produce information backgrounds of multi-scale spontaneous activity that become more complex in brain stat …
Providing a sense of touch to prosthetic hands.
Nghiem BT, Sando IC, Gillespie RB, McLaughlin BL, Gerling GJ, Langhals NB, Urbanchek MG, Cederna PS. Nghiem BT, et al. Plast Reconstr Surg. 2015 Jun;135(6):1652-1663. doi: 10.1097/PRS.0000000000001289. Plast Reconstr Surg. 2015. PMID: 26017599 Review.
A comprehensive neural simulation of slow-wave sleep and highly responsive wakefulness dynamics.
Goldman JS, Kusch L, Aquilue D, Yalçınkaya BH, Depannemaecker D, Ancourt K, Nghiem TE, Jirsa V, Destexhe A. Goldman JS, et al. Front Comput Neurosci. 2023 Jan 13;16:1058957. doi: 10.3389/fncom.2022.1058957. eCollection 2022. Front Comput Neurosci. 2023. PMID: 36714530 Free PMC article.
Hallmarks of neural dynamics during healthy human brain states span spatial scales from neuromodulators acting on microscopic ion channels to macroscopic changes in communication between brain regions. ...The model was run using The Virtual Brain (TVB) simula …
Hallmarks of neural dynamics during healthy human brain states span spatial scales from neuromodulators acting on microscopic ion cha …
Space wandering in the rodent default mode network.
Nghiem TE, Lee B, Chao TH, Branigan NK, Mistry PK, Shih YI, Menon V. Nghiem TE, et al. bioRxiv [Preprint]. 2023 Sep 1:2023.08.31.555793. doi: 10.1101/2023.08.31.555793. bioRxiv. 2023. PMID: 37693501 Free PMC article. Updated. Preprint.
The default mode network (DMN) is a large-scale brain network known to be suppressed during a wide range of cognitive tasks. ...By illuminating the DMN's role in naturalistic behaviors, our study underscores the importance of investigating brain network function in …
The default mode network (DMN) is a large-scale brain network known to be suppressed during a wide range of cognitive tasks. ...By il …
PERK activation by SB202190 ameliorates amyloidogenesis via the TFEB-induced autophagy-lysosomal pathway.
Do M, Park J, Chen Y, Rah SY, Nghiem TT, Gong JH, Ju SA, Kim BS, Yu R, Park JW, Ryter SW, Surh YJ, Kim UH, Joe Y, Chung HT. Do M, et al. Aging (Albany NY). 2022 Feb 15;14(3):1233-1252. doi: 10.18632/aging.203899. Epub 2022 Feb 15. Aging (Albany NY). 2022. PMID: 35166693 Free PMC article.
In neurodegenerative diseases, the ALP ameliorates the accumulation of intracellular protein aggregates in the brain. Transcription factor-EB (TFEB), a master regulator of the ALP, positively regulates key genes involved in the cellular degradative pathway. ...
In neurodegenerative diseases, the ALP ameliorates the accumulation of intracellular protein aggregates in the brain. Transcription f …
Evaluation of brain tissue or cerebrospinal fluid with broadly reactive polymerase chain reaction for Ehrlichia, Anaplasma, spotted fever group Rickettsia, Bartonella, and Borrelia species in canine neurological diseases (109 cases).
Barber RM, Li Q, Diniz PP, Porter BF, Breitschwerdt EB, Claiborne MK, Birkenheuer AJ, Levine JM, Levine GJ, Chandler K, Kenny P, Nghiem P, Wei S, Greene CE, Kent M, Platt SR, Greer K, Schatzberg SJ. Barber RM, et al. J Vet Intern Med. 2010 Mar-Apr;24(2):372-8. doi: 10.1111/j.1939-1676.2009.0466.x. J Vet Intern Med. 2010. PMID: 20102497 Free article.
BACKGROUND: Vector-transmitted microorganisms in the genera Ehrlichia, Anaplasma, Rickettsia, Bartonella, and Borrelia are commonly suspected in dogs with meningoencephalomyelitis (MEM), but the prevalence of these pathogens in brain tissue and cerebrospinal fluid (CSF) of …
BACKGROUND: Vector-transmitted microorganisms in the genera Ehrlichia, Anaplasma, Rickettsia, Bartonella, and Borrelia are commonly suspecte …
Space wandering in the rodent default mode network.
Nghiem TE, Lee B, Chao TH, Branigan NK, Mistry PK, Shih YI, Menon V. Nghiem TE, et al. Proc Natl Acad Sci U S A. 2024 Apr 9;121(15):e2315167121. doi: 10.1073/pnas.2315167121. Epub 2024 Apr 1. Proc Natl Acad Sci U S A. 2024. PMID: 38557177
The default mode network (DMN) is a large-scale brain network known to be suppressed during a wide range of cognitive tasks. ...By illuminating the DMN's role in naturalistic behaviors, our study underscores the importance of investigating brain network function in …
The default mode network (DMN) is a large-scale brain network known to be suppressed during a wide range of cognitive tasks. ...By il …
Cholinergic Switch between Two Types of Slow Waves in Cerebral Cortex.
Nghiem TE, Tort-Colet N, Górski T, Ferrari U, Moghimyfiroozabad S, Goldman JS, Teleńczuk B, Capone C, Bal T, di Volo M, Destexhe A. Nghiem TE, et al. Cereb Cortex. 2020 May 18;30(6):3451-3466. doi: 10.1093/cercor/bhz320. Cereb Cortex. 2020. PMID: 31989160 Free article.
Adverse effects of maternal dioxin exposure on fetal brain development before birth assessed by neonatal electroencephalography (EEG) leading to poor neurodevelopment; a 2-year follow-up study.
Nghiem GT, Nishijo M, Pham TN, Ito M, Pham TT, Tran AH, Nishimaru H, Nishino Y, Nishijo H. Nghiem GT, et al. Sci Total Environ. 2019 Jun 1;667:718-729. doi: 10.1016/j.scitotenv.2019.02.395. Epub 2019 Feb 27. Sci Total Environ. 2019. PMID: 30849612
In the present study, we investigated the effects of maternal dioxin exposure on fetal brain development, which may predict neurodevelopmental outcomes in early childhood. ...These findings suggest that prenatal dioxin exposure affects neuronal activity and functional conn …
In the present study, we investigated the effects of maternal dioxin exposure on fetal brain development, which may predict neurodeve …
31 results