Hepatocyte-specific deletion of cellular repressor of E1A-stimulated genes 1 exacerbates alcohol-induced liver injury by activating stress kinases.
Wu M, Yin F, Wei X, Ren R, Chen C, Liu M, Wang R, Yang L, Xie R, Jiang S, Wang Z, Liu R, Xu W, Wang X, Li J, Wang H.
Wu M, et al.
Int J Biol Sci. 2022 Jan 31;18(4):1612-1626. doi: 10.7150/ijbs.67852. eCollection 2022.
Int J Biol Sci. 2022.
PMID: 35280676
Free PMC article.
Elevation of hepatic CREG1 protein and mRNA was also observed in a mouse model of Gao-binge alcohol feeding. Genetic deletion of the Creg1 gene in hepatocytes (Creg1(hep) ) markedly exacerbated ethanol-induced liver injury, apoptosis, steatosis and inflammation. ...
Elevation of hepatic CREG1 protein and mRNA was also observed in a mouse model of Gao-binge alcohol feeding. Genetic deletion of the …