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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 1
1984 3
1985 4
1986 2
1987 3
1988 1
1989 6
1990 17
1991 30
1992 23
1993 32
1994 42
1995 58
1996 61
1997 94
1998 92
1999 107
2000 129
2001 120
2002 154
2003 200
2004 245
2005 277
2006 284
2007 285
2008 307
2009 397
2010 466
2011 519
2012 584
2013 686
2014 757
2015 834
2016 864
2017 898
2018 973
2019 1107
2020 1286
2021 1365
2022 1273
2023 1293
2024 651

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14,832 results

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Page 1
G-quadruplexes associated with R-loops promote CTCF binding.
Wulfridge P, Yan Q, Rell N, Doherty J, Jacobson S, Offley S, Deliard S, Feng K, Phillips-Cremins JE, Gardini A, Sarma K. Wulfridge P, et al. Mol Cell. 2023 Sep 7;83(17):3064-3079.e5. doi: 10.1016/j.molcel.2023.07.009. Epub 2023 Aug 7. Mol Cell. 2023. PMID: 37552993
CTCF is a critical regulator of genome architecture and gene expression that binds thousands of sites on chromatin. CTCF genomic localization is controlled by the recognition of a DNA sequence motif and regulated by DNA modifications. ...R-loops and G4s co-localize with CT …
CTCF is a critical regulator of genome architecture and gene expression that binds thousands of sites on chromatin. CTCF genomic loca …
Cannabidiol inhibits Na(v) channels through two distinct binding sites.
Huang J, Fan X, Jin X, Jo S, Zhang HB, Fujita A, Bean BP, Yan N. Huang J, et al. Nat Commun. 2023 Jun 17;14(1):3613. doi: 10.1038/s41467-023-39307-6. Nat Commun. 2023. PMID: 37330538 Free PMC article.
The cryo-EM structure of CBD bound to Na(v)1.7 channels reveals two distinct binding sites. One is in the IV-I fenestration near the upper pore. ...Consistent with producing a direct stabilization of the inactivated state, mutating residues in this binding site grea …
The cryo-EM structure of CBD bound to Na(v)1.7 channels reveals two distinct binding sites. One is in the IV-I fenestration near the …
PHGDH Inhibits Ferroptosis and Promotes Malignant Progression by Upregulating SLC7A11 in Bladder Cancer.
Shen L, Zhang J, Zheng Z, Yang F, Liu S, Wu Y, Chen Y, Xu T, Mao S, Yan Y, Li W, Zhang W, Yao X. Shen L, et al. Int J Biol Sci. 2022 Aug 29;18(14):5459-5474. doi: 10.7150/ijbs.74546. eCollection 2022. Int J Biol Sci. 2022. PMID: 36147463 Free PMC article.
Additionally, PHGDH knock-down downregulated the expression of SLC7A11. Co-IP and mass spectrometry experiments indicate that PHGDH binds to PCBP2, an RNA-binding protein, and inhibits its ubiquitination degradation. ...
Additionally, PHGDH knock-down downregulated the expression of SLC7A11. Co-IP and mass spectrometry experiments indicate that PHGDH binds …
The miniature CRISPR-Cas12m effector binds DNA to block transcription.
Wu WY, Mohanraju P, Liao C, Adiego-Pérez B, Creutzburg SCA, Makarova KS, Keessen K, Lindeboom TA, Khan TS, Prinsen S, Joosten R, Yan WX, Migur A, Laffeber C, Scott DA, Lebbink JHG, Koonin EV, Beisel CL, van der Oost J. Wu WY, et al. Mol Cell. 2022 Dec 1;82(23):4487-4502.e7. doi: 10.1016/j.molcel.2022.11.003. Epub 2022 Nov 24. Mol Cell. 2022. PMID: 36427491 Free article.
Despite being less than half the size of Cas12a, Cas12m catalyzes auto-processing of a crRNA guide, recognizes a 5'-TTN' protospacer-adjacent motif (PAM), and stably binds a guide-complementary double-stranded DNA (dsDNA). Cas12m has a RuvC domain with a non-canonical cata …
Despite being less than half the size of Cas12a, Cas12m catalyzes auto-processing of a crRNA guide, recognizes a 5'-TTN' protospacer-adjacen …
An oncopeptide regulates m6A recognition by the m6A reader IGF2BP1 and tumorigenesis.
Zhu S, Wang JZ, Chen D, He YT, Meng N, Chen M, Lu RX, Chen XH, Zhang XL, Yan GR. Zhu S, et al. Nat Commun. 2020 Apr 3;11(1):1685. doi: 10.1038/s41467-020-15403-9. Nat Commun. 2020. PMID: 32245947 Free PMC article.
Here we discover that the long noncoding RNA (lncRNA) LINC00266-1 encodes a 71-amino acid peptide. The peptide mainly interacts with the RNA-binding proteins, including the m(6)A reader IGF2BP1, and is thus named "RNA-binding regulatory peptide" (RBRP). RBRP bind …
Here we discover that the long noncoding RNA (lncRNA) LINC00266-1 encodes a 71-amino acid peptide. The peptide mainly interacts with the RNA …
KAT7-mediated CANX (calnexin) crotonylation regulates leucine-stimulated MTORC1 activity.
Yan G, Li X, Zheng Z, Gao W, Chen C, Wang X, Cheng Z, Yu J, Zou G, Farooq MZ, Zhu X, Zhu W, Zhong Q, Yan X. Yan G, et al. Autophagy. 2022 Dec;18(12):2799-2816. doi: 10.1080/15548627.2022.2047481. Epub 2022 Mar 10. Autophagy. 2022. PMID: 35266843 Free PMC article.
CANX translocates to lysosomes after leucine deprivation, and its loss of function renders either the MTORC1 activity or the lysosomal translocation of MTOR insensitive to leucine deprivation. We further find that CANX binds to LAMP2 (lysosomal associated membrane protein …
CANX translocates to lysosomes after leucine deprivation, and its loss of function renders either the MTORC1 activity or the lysosomal trans …
A Peptide Encoded by a Putative lncRNA HOXB-AS3 Suppresses Colon Cancer Growth.
Huang JZ, Chen M, Chen D, Gao XC, Zhu S, Huang H, Hu M, Zhu H, Yan GR. Huang JZ, et al. Mol Cell. 2017 Oct 5;68(1):171-184.e6. doi: 10.1016/j.molcel.2017.09.015. Mol Cell. 2017. PMID: 28985503 Free article.
The HOXB-AS3 peptide, not lncRNA, suppresses colon cancer (CRC) growth. Mechanistically, the HOXB-AS3 peptide competitively binds to the ariginine residues in RGG motif of hnRNP A1 and antagonizes the hnRNP A1-mediated regulation of pyruvate kinase M (PKM) splicing by bloc …
The HOXB-AS3 peptide, not lncRNA, suppresses colon cancer (CRC) growth. Mechanistically, the HOXB-AS3 peptide competitively binds to …
A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo.
Li S, Jiang Q, Liu S, Zhang Y, Tian Y, Song C, Wang J, Zou Y, Anderson GJ, Han JY, Chang Y, Liu Y, Zhang C, Chen L, Zhou G, Nie G, Yan H, Ding B, Zhao Y. Li S, et al. Nat Biotechnol. 2018 Mar;36(3):258-264. doi: 10.1038/nbt.4071. Epub 2018 Feb 12. Nat Biotechnol. 2018. PMID: 29431737
Our nanorobot is functionalized on the outside with a DNA aptamer that binds nucleolin, a protein specifically expressed on tumor-associated endothelial cells, and the blood coagulation protease thrombin within its inner cavity. ...
Our nanorobot is functionalized on the outside with a DNA aptamer that binds nucleolin, a protein specifically expressed on tumor-ass …
Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis.
Kwiatkowski TJ Jr, Bosco DA, Leclerc AL, Tamrazian E, Vanderburg CR, Russ C, Davis A, Gilchrist J, Kasarskis EJ, Munsat T, Valdmanis P, Rouleau GA, Hosler BA, Cortelli P, de Jong PJ, Yoshinaga Y, Haines JL, Pericak-Vance MA, Yan J, Ticozzi N, Siddique T, McKenna-Yasek D, Sapp PC, Horvitz HR, Landers JE, Brown RH Jr. Kwiatkowski TJ Jr, et al. Science. 2009 Feb 27;323(5918):1205-8. doi: 10.1126/science.1166066. Science. 2009. PMID: 19251627
We report here 13 mutations in the fused in sarcoma/translated in liposarcoma (FUS/TLS) gene on chromosome 16 that were specific for familial ALS. The FUS/TLS protein binds to RNA, functions in diverse processes, and is normally located predominantly in the nucleus. In con …
We report here 13 mutations in the fused in sarcoma/translated in liposarcoma (FUS/TLS) gene on chromosome 16 that were specific for familia …
Tail engagement of arrestin at the glucagon receptor.
Chen K, Zhang C, Lin S, Yan X, Cai H, Yi C, Ma L, Chu X, Liu Y, Zhu Y, Han S, Zhao Q, Wu B. Chen K, et al. Nature. 2023 Aug;620(7975):904-910. doi: 10.1038/s41586-023-06420-x. Epub 2023 Aug 9. Nature. 2023. PMID: 37558880 Free PMC article.
Arrestins have pivotal roles in regulating G protein-coupled receptor (GPCR) signalling by desensitizing G protein activation and mediating receptor internalization(1,2). It has been proposed that the arrestin binds to the receptor in two different conformations, 'tail' an …
Arrestins have pivotal roles in regulating G protein-coupled receptor (GPCR) signalling by desensitizing G protein activation and mediating …
14,832 results
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