Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 1
1978 2
1980 1
1984 1
1989 1
1990 3
1991 3
1992 1
1993 14
1994 15
1995 13
1996 10
1997 15
1998 19
1999 19
2000 11
2001 20
2002 28
2003 28
2004 32
2005 38
2006 43
2007 50
2008 45
2009 43
2010 47
2011 73
2012 97
2013 98
2014 120
2015 112
2016 121
2017 107
2018 160
2019 130
2020 145
2021 140
2022 148
2023 169
2024 64

Text availability

Article attribute

Article type

Publication date

Search Results

1,949 results

Results by year

Filters applied: . Clear all
Page 1
The m6A reader IGF2BP2 regulates glutamine metabolism and represents a therapeutic target in acute myeloid leukemia.
Weng H, Huang F, Yu Z, Chen Z, Prince E, Kang Y, Zhou K, Li W, Hu J, Fu C, Aziz T, Li H, Li J, Yang Y, Han L, Zhang S, Ma Y, Sun M, Wu H, Zhang Z, Wunderlich M, Robinson S, Braas D, Hoeve JT, Zhang B, Marcucci G, Mulloy JC, Zhou K, Tao HF, Deng X, Horne D, Wei M, Huang H, Chen J. Weng H, et al. Cancer Cell. 2022 Dec 12;40(12):1566-1582.e10. doi: 10.1016/j.ccell.2022.10.004. Epub 2022 Oct 27. Cancer Cell. 2022. PMID: 36306790 Free PMC article.
N(6)-Methyladenosine (m(6)A) modification and its modulators play critical roles and show promise as therapeutic targets in human cancers, including acute myeloid leukemia (AML). IGF2BP2 was recently reported as an m(6)A binding protein that enhances mRNA stability and tra …
N(6)-Methyladenosine (m(6)A) modification and its modulators play critical roles and show promise as therapeutic targets in human cancers, i …
Emerging views of OPTN (optineurin) function in the autophagic process associated with disease.
Qiu Y, Wang J, Li H, Yang B, Wang J, He Q, Weng Q. Qiu Y, et al. Autophagy. 2022 Jan;18(1):73-85. doi: 10.1080/15548627.2021.1908722. Epub 2021 Apr 13. Autophagy. 2022. PMID: 33783320 Free PMC article. Review.
A comprehensive review of the function of OPTN in autophagy provides valuable insight into the pathogenesis of human diseases related to OPTN and facilitates the discovery of potential key regulators and novel therapeutic targets for disease intervention in patients with autophag …
A comprehensive review of the function of OPTN in autophagy provides valuable insight into the pathogenesis of human diseases related to OPT …
CD1d facilitates African swine fever virus entry into the host cells via clathrin-mediated endocytosis.
Chen X, Zheng J, Liu C, Li T, Wang X, Li X, Bao M, Li J, Huang L, Zhang Z, Bu Z, Weng C. Chen X, et al. Emerg Microbes Infect. 2023 Dec;12(2):2220575. doi: 10.1080/22221751.2023.2220575. Emerg Microbes Infect. 2023. PMID: 37254454 Free PMC article.
As the main capsid protein on the surface of ASFV virions, p72 can mediate viral entry. Using IP-MS assay, CD1d was identified as a binding partner of p72 on surface of ASFV virions. Knockdown of CD1d expression and blocking the cells with anti-pCD1d antibody, or incubatin …
As the main capsid protein on the surface of ASFV virions, p72 can mediate viral entry. Using IP-MS assay, CD1d was identified as a bindi …
Motif Finding.
Hung JH, Weng Z. Hung JH, et al. Cold Spring Harb Protoc. 2017 Feb 1;2017(2). doi: 10.1101/pdb.top093195. Cold Spring Harb Protoc. 2017. PMID: 27574195
Here we provide an introduction to sequence motifs, including prediction of transcription factor-binding sites and general approaches to finding motifs enriched in a set of regulatory sequences....
Here we provide an introduction to sequence motifs, including prediction of transcription factor-binding sites and general approaches …
Structural and mechanistic insights into the MCM8/9 helicase complex.
Weng Z, Zheng J, Zhou Y, Lu Z, Wu Y, Xu D, Li H, Liang H, Liu Y. Weng Z, et al. Elife. 2023 Aug 3;12:RP87468. doi: 10.7554/eLife.87468. Elife. 2023. PMID: 37535404 Free PMC article.
MCM8 and MCM9 form a functional helicase complex (MCM8/9) that plays an essential role in DNA homologous recombination repair for DNA double-strand break. However, the structural characterization of MCM8/9 for DNA binding/unwinding remains unclear. Here, we report structur …
MCM8 and MCM9 form a functional helicase complex (MCM8/9) that plays an essential role in DNA homologous recombination repair for DNA double …
Fibroblastic reticular cell-derived exosomes are a promising therapeutic approach for septic acute kidney injury.
Li Y, Hu C, Zhai P, Zhang J, Jiang J, Suo J, Hu B, Wang J, Weng X, Zhou X, Billiar TR, Kellum JA, Deng M, Peng Z. Li Y, et al. Kidney Int. 2024 Mar;105(3):508-523. doi: 10.1016/j.kint.2023.12.007. Epub 2023 Dec 30. Kidney Int. 2024. PMID: 38163633 Free article.
FRCs were infected with a CD5L lentivirus to increase CD5L levels in FRC-Exos, which were then modified in vitro with the kidney tubular cell targeting peptide LTH, a peptide that binds to the biomarker protein kidney injury molecule-1 expressed on injured tubule cells, to …
FRCs were infected with a CD5L lentivirus to increase CD5L levels in FRC-Exos, which were then modified in vitro with the kidney tubular cel …
A TRIM21-based bioPROTAC highlights the therapeutic benefit of HuR degradation.
Fletcher A, Clift D, de Vries E, Martinez Cuesta S, Malcolm T, Meghini F, Chaerkady R, Wang J, Chiang A, Weng SHS, Tart J, Wong E, Donohoe G, Rawlins P, Gordon E, Taylor JD, James L, Hunt J. Fletcher A, et al. Nat Commun. 2023 Nov 4;14(1):7093. doi: 10.1038/s41467-023-42546-2. Nat Commun. 2023. PMID: 37925433 Free PMC article.
Human antigen R (HuR) is a ubiquitously expressed RNA-binding protein, which functions as an RNA regulator. Overexpression of HuR correlates with high grade tumours and poor patient prognosis, implicating it as an attractive therapeutic target. However, an effective small …
Human antigen R (HuR) is a ubiquitously expressed RNA-binding protein, which functions as an RNA regulator. Overexpression of HuR cor …
Discovering cis-Regulatory Motifs.
Hung JH, Weng Z. Hung JH, et al. Cold Spring Harb Protoc. 2017 Feb 1;2017(2). doi: 10.1101/pdb.prot093203. Cold Spring Harb Protoc. 2017. PMID: 27574199
The first part of this protocol demonstrates the use of MEME (ab initio motif discovery), JASPAR (a motif database), Clover (searching for enriched known motifs), and MAST (scanning a sequence for motif sites) on a set of computationally predicted CREB-binding sequences do …
The first part of this protocol demonstrates the use of MEME (ab initio motif discovery), JASPAR (a motif database), Clover (searching for e …
Identification of a Putative α-synuclein Radioligand Using an in silico Similarity Search.
Janssen B, Tian G, Lengyel-Zhand Z, Hsieh CJ, Lougee MG, Riad A, Xu K, Hou C, Weng CC, Lopresti BJ, Kim HJ, Pagar VV, Ferrie JJ, Garcia BA, Mathis CA, Luk K, Petersson EJ, Mach RH. Janssen B, et al. Mol Imaging Biol. 2023 Aug;25(4):704-719. doi: 10.1007/s11307-023-01814-9. Epub 2023 Mar 29. Mol Imaging Biol. 2023. PMID: 36991273
METHODS: Using 1 as a lead compound in a similarity search, isoxazole derivative 15 was identified to bind to alpha-synuclein fibrils with high affinity in competition binding assays. A photocrosslinkable version was used to confirm binding site preference. ...K(d) …
METHODS: Using 1 as a lead compound in a similarity search, isoxazole derivative 15 was identified to bind to alpha-synuclein fibrils with h …
1,949 results