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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1983 3
1984 2
1985 1
1987 2
1988 2
1989 7
1990 13
1991 18
1992 17
1993 23
1994 34
1995 23
1996 24
1997 41
1998 44
1999 40
2000 35
2001 51
2002 62
2003 84
2004 86
2005 97
2006 105
2007 98
2008 121
2009 154
2010 148
2011 180
2012 209
2013 244
2014 265
2015 306
2016 280
2017 318
2018 345
2019 411
2020 413
2021 450
2022 427
2023 462
2024 189

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5,232 results

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Page 1
RNA binding protein RBM46 regulates mitotic-to-meiotic transition in spermatogenesis.
Qian B, Li Y, Yan R, Han S, Bu Z, Gong J, Zheng B, Yuan Z, Ren S, He Q, Zhang J, Xu C, Wang R, Sun Z, Lin M, Zhou J, Ye L. Qian B, et al. Sci Adv. 2022 Aug 26;8(34):eabq2945. doi: 10.1126/sciadv.abq2945. Epub 2022 Aug 24. Sci Adv. 2022. PMID: 36001654 Free PMC article.
RNA helicase YTHDC2 and its partner MEIOC emerge as essential posttranscriptional regulators of meiotic entry. However, it is unclear what governs the RNA binding specificity of YTHDC2/MEIOC. Here, we identified RNA binding protein RBM46 as a component of the YTHDC2 …
RNA helicase YTHDC2 and its partner MEIOC emerge as essential posttranscriptional regulators of meiotic entry. However, it is unclear what g …
The transcription factor ZEB2 drives the formation of age-associated B cells.
Dai D, Gu S, Han X, Ding H, Jiang Y, Zhang X, Yao C, Hong S, Zhang J, Shen Y, Hou G, Qu B, Zhou H, Qin Y, He Y, Ma J, Yin Z, Ye Z, Qian J, Jiang Q, Wu L, Guo Q, Chen S, Huang C, Kottyan LC, Weirauch MT, Vinuesa CG, Shen N. Dai D, et al. Science. 2024 Jan 26;383(6681):413-421. doi: 10.1126/science.adf8531. Epub 2024 Jan 25. Science. 2024. PMID: 38271512
In this study, we screened for transcription factors driving ABC formation and found that zinc finger E-box binding homeobox 2 (ZEB2) is required for human and mouse ABC differentiation in vitro. ...In mice with toll-like receptor 7 (TLR7)-driven lupus, ZEB2 is essential f …
In this study, we screened for transcription factors driving ABC formation and found that zinc finger E-box binding homeobox 2 (ZEB2) …
The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome.
Zhu F, Ma J, Li W, Liu Q, Qin X, Qian Y, Wang C, Zhang Y, Li Y, Jiang D, Wang S, Xia P. Zhu F, et al. Immunity. 2023 Apr 11;56(4):753-767.e8. doi: 10.1016/j.immuni.2023.03.003. Epub 2023 Mar 30. Immunity. 2023. PMID: 37001519
Biochemical mapping revealed that Nur77 bound LPS directly through a domain in its C terminus. Yeast two-hybrid assays identified NLRP3 as a binding partner for Nur77. The association between Nur77 and NLRP3 required the presence of LPS and dsDNA. ...In vivo, Nur77 deficie …
Biochemical mapping revealed that Nur77 bound LPS directly through a domain in its C terminus. Yeast two-hybrid assays identified NLRP3 as a …
5' UTR m(6)A Promotes Cap-Independent Translation.
Meyer KD, Patil DP, Zhou J, Zinoviev A, Skabkin MA, Elemento O, Pestova TV, Qian SB, Jaffrey SR. Meyer KD, et al. Cell. 2015 Nov 5;163(4):999-1010. doi: 10.1016/j.cell.2015.10.012. Epub 2015 Oct 22. Cell. 2015. PMID: 26593424 Free PMC article.
Protein translation typically begins with the recruitment of the 43S ribosomal complex to the 5' cap of mRNAs by a cap-binding complex. However, some transcripts are translated in a cap-independent manner through poorly understood mechanisms. Here, we show that mRNAs conta …
Protein translation typically begins with the recruitment of the 43S ribosomal complex to the 5' cap of mRNAs by a cap-binding comple …
Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β.
Arndt JW, Qian F, Smith BA, Quan C, Kilambi KP, Bush MW, Walz T, Pepinsky RB, Bussière T, Hamann S, Cameron TO, Weinreb PH. Arndt JW, et al. Sci Rep. 2018 Apr 23;8(1):6412. doi: 10.1038/s41598-018-24501-0. Sci Rep. 2018. PMID: 29686315 Free PMC article.
Aducanumab, a human-derived antibody targeting amyloid-beta (Abeta), is in Phase 3 clinical trials for the treatment of Alzheimer's disease. Biochemical and structural analyses show that aducanumab binds a linear epitope formed by amino acids 3-7 of the Abeta peptide. Aduc …
Aducanumab, a human-derived antibody targeting amyloid-beta (Abeta), is in Phase 3 clinical trials for the treatment of Alzheimer's disease. …
Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy.
Li X, Yu W, Qian X, Xia Y, Zheng Y, Lee JH, Li W, Lyu J, Rao G, Zhang X, Qian CN, Rozen SG, Jiang T, Lu Z. Li X, et al. Mol Cell. 2017 Jun 1;66(5):684-697.e9. doi: 10.1016/j.molcel.2017.04.026. Epub 2017 May 25. Mol Cell. 2017. PMID: 28552616 Free PMC article.
We demonstrate here that glucose deprivation results in AMP-activated protein kinase (AMPK)-mediated acetyl-CoA synthetase 2 (ACSS2) phosphorylation at S659, which exposed the nuclear localization signal of ACSS2 for importin alpha5 binding and nuclear translocation. In th …
We demonstrate here that glucose deprivation results in AMP-activated protein kinase (AMPK)-mediated acetyl-CoA synthetase 2 (ACSS2) phospho …
A novel miR167a-OsARF6-OsAUX3 module regulates grain length and weight in rice.
Qiao J, Jiang H, Lin Y, Shang L, Wang M, Li D, Fu X, Geisler M, Qi Y, Gao Z, Qian Q. Qiao J, et al. Mol Plant. 2021 Oct 4;14(10):1683-1698. doi: 10.1016/j.molp.2021.06.023. Epub 2021 Jun 27. Mol Plant. 2021. PMID: 34186219 Free article.
RNA sequencing, gene expression quantification, dual-luciferase reporter assays, chromatin immunoprecipitation-quantitative PCR, and yeast one-hybrid assays demonstrated that OsARF6 is an upstream transcription factor regulating the expression of OsAUX3. OsARF6 binds direc …
RNA sequencing, gene expression quantification, dual-luciferase reporter assays, chromatin immunoprecipitation-quantitative PCR, and yeast o …
KAT2A coupled with the α-KGDH complex acts as a histone H3 succinyltransferase.
Wang Y, Guo YR, Liu K, Yin Z, Liu R, Xia Y, Tan L, Yang P, Lee JH, Li XJ, Hawke D, Zheng Y, Qian X, Lyu J, He J, Xing D, Tao YJ, Lu Z. Wang Y, et al. Nature. 2017 Dec 14;552(7684):273-277. doi: 10.1038/nature25003. Epub 2017 Dec 6. Nature. 2017. PMID: 29211711 Free PMC article.
Here we show that the alpha-ketoglutarate dehydrogenase (alpha-KGDH) complex is localized in the nucleus in human cell lines and binds to lysine acetyltransferase 2A (KAT2A, also known as GCN5) in the promoter regions of genes. We show that succinyl-coenzyme A (succinyl-Co …
Here we show that the alpha-ketoglutarate dehydrogenase (alpha-KGDH) complex is localized in the nucleus in human cell lines and binds …
Homeodomain-DNA recognition.
Gehring WJ, Qian YQ, Billeter M, Furukubo-Tokunaga K, Schier AF, Resendez-Perez D, Affolter M, Otting G, Wüthrich K. Gehring WJ, et al. Cell. 1994 Jul 29;78(2):211-23. doi: 10.1016/0092-8674(94)90292-5. Cell. 1994. PMID: 8044836 Review. No abstract available.
Exploring the mechanism of action of Qian Lie Xing Fang during the treatment of benign prostatic hyperplasia via network pharmacology and molecular dynamics simulation analyses.
Xiang J, Li Z, Wang C. Xiang J, et al. Medicine (Baltimore). 2023 Oct 20;102(42):e35540. doi: 10.1097/MD.0000000000035540. Medicine (Baltimore). 2023. PMID: 37861557 Free PMC article.
This study aimed to explore the historical research progress on benign prostatic hyperplasia from the perspective of traditional Chinese medicine theory and the treatment of benign prostatic hyperplasia (BPH) with Qian Lie Xing Fang (QLXF) via the warming and tonifying of …
This study aimed to explore the historical research progress on benign prostatic hyperplasia from the perspective of traditional Chinese med …
5,232 results