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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1960 1
1968 1
1969 4
1970 1
1971 2
1973 2
1974 2
1975 3
1976 7
1977 5
1978 2
1979 5
1980 1
1981 2
1982 3
1983 2
1985 1
1986 1
1987 1
1988 3
1989 4
1990 10
1991 20
1992 18
1993 25
1994 21
1995 26
1996 24
1997 36
1998 52
1999 53
2000 67
2001 60
2002 102
2003 102
2004 138
2005 152
2006 171
2007 196
2008 238
2009 238
2010 273
2011 294
2012 344
2013 473
2014 462
2015 500
2016 528
2017 552
2018 578
2019 684
2020 676
2021 793
2022 858
2023 777
2024 364

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8,947 results

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Page 1
A gut-derived hormone regulates cholesterol metabolism.
Hu X, Chen F, Jia L, Long A, Peng Y, Li X, Huang J, Wei X, Fang X, Gao Z, Zhang M, Liu X, Chen YG, Wang Y, Zhang H, Wang Y. Hu X, et al. Cell. 2024 Mar 28;187(7):1685-1700.e18. doi: 10.1016/j.cell.2024.02.024. Epub 2024 Mar 18. Cell. 2024. PMID: 38503280
It is secreted from the intestine in response to cholesterol absorption and binds to GPR146, an orphan G-protein-coupled receptor, exerting antagonistic downstream effects by inhibiting PKA signaling and thereby suppressing SREBP2-controlled cholesterol synthesis in the li …
It is secreted from the intestine in response to cholesterol absorption and binds to GPR146, an orphan G-protein-coupled receptor, ex …
Adiponectin Regulation and Function.
Fang H, Judd RL. Fang H, et al. Compr Physiol. 2018 Jun 18;8(3):1031-1063. doi: 10.1002/cphy.c170046. Compr Physiol. 2018. PMID: 29978896 Review.
Adiponectin is posttranslationally modified from a 30-kDa monomeric protein into different multimers (low molecular weight or trimer, middle molecular weight or hexamer, and high molecular weight) and secreted into the circulation. Upon binding to its receptors, AdipoR1 an …
Adiponectin is posttranslationally modified from a 30-kDa monomeric protein into different multimers (low molecular weight or trimer, middle …
The RNA-binding protein LRPPRC promotes resistance to CDK4/6 inhibition in lung cancer.
Zhou W, Wang W, Liang Y, Jiang R, Qiu F, Shao X, Liu Y, Fang L, Ni M, Yu C, Zhao Y, Huang W, Li J, Donovan MJ, Wang L, Ni J, Wang D, Fu T, Feng J, Wang X, Tan W, Fang X. Zhou W, et al. Nat Commun. 2023 Jul 14;14(1):4212. doi: 10.1038/s41467-023-39854-y. Nat Commun. 2023. PMID: 37452037 Free PMC article.
Here, we demonstrate that Leucine Rich Pentatricopeptide Repeat Containing (LRPPRC) controls CDK4/6i response in lung cancer by forming a feedback loop with CDK6. LRPPRC binds to CDK6-mRNA, increasing the stability and expression of CDK6. ...
Here, we demonstrate that Leucine Rich Pentatricopeptide Repeat Containing (LRPPRC) controls CDK4/6i response in lung cancer by forming a fe …
Inhibiting Ferroptosis through Disrupting the NCOA4-FTH1 Interaction: A New Mechanism of Action.
Fang Y, Chen X, Tan Q, Zhou H, Xu J, Gu Q. Fang Y, et al. ACS Cent Sci. 2021 Jun 23;7(6):980-989. doi: 10.1021/acscentsci.0c01592. Epub 2021 May 6. ACS Cent Sci. 2021. PMID: 34235259 Free PMC article.
Compound 9a blocks ferroptosis by reducing the amount of bioavailable intracellular ferrous iron through disrupting the NCOA4-FTH1 protein-protein interaction. Further studies indicate that 9a directly binds to recombinant protein NCOA4(383-522) and effectively blocks the …
Compound 9a blocks ferroptosis by reducing the amount of bioavailable intracellular ferrous iron through disrupting the NCOA4-FTH1 protein-p …
ITPRIPL1 binds CD3epsilon to impede T cell activation and enable tumor immune evasion.
Deng S, Zhang Y, Wang H, Liang W, Xie L, Li N, Fang Y, Wang Y, Liu J, Chi H, Sun Y, Ye R, Shan L, Shi J, Shen Z, Wang Y, Wang S, Brosseau JP, Wang F, Liu G, Quan Y, Xu J. Deng S, et al. Cell. 2024 Apr 25;187(9):2305-2323.e33. doi: 10.1016/j.cell.2024.03.019. Epub 2024 Apr 12. Cell. 2024. PMID: 38614099
Here, we show that ITPRIPL1 functions as an inhibitory ligand of CD3epsilon, and its expression inhibits T cells in the tumor microenvironment. The binding of ITPRIPL1 extracellular domain to CD3epsilon on T cells significantly decreased calcium influx and ZAP70 phosphoryl …
Here, we show that ITPRIPL1 functions as an inhibitory ligand of CD3epsilon, and its expression inhibits T cells in the tumor microenvironme …
Famsin, a novel gut-secreted hormone, contributes to metabolic adaptations to fasting via binding to its receptor OLFR796.
Long A, Liu Y, Fang X, Jia L, Li Z, Hu J, Wu S, Chen C, Huang P, Wang Y. Long A, et al. Cell Res. 2023 Apr;33(4):273-287. doi: 10.1038/s41422-023-00782-7. Epub 2023 Feb 17. Cell Res. 2023. PMID: 36806353 Free PMC article.
Mechanistically, famsin is shed from a single-pass transmembrane protein, Gm11437, during fasting and then binds OLFR796, an olfactory receptor, to activate intracellular calcium mobilization. ...
Mechanistically, famsin is shed from a single-pass transmembrane protein, Gm11437, during fasting and then binds OLFR796, an olfactor …
A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase.
Matyskiela ME, Lu G, Ito T, Pagarigan B, Lu CC, Miller K, Fang W, Wang NY, Nguyen D, Houston J, Carmel G, Tran T, Riley M, Nosaka L, Lander GC, Gaidarova S, Xu S, Ruchelman AL, Handa H, Carmichael J, Daniel TO, Cathers BE, Lopez-Girona A, Chamberlain PP. Matyskiela ME, et al. Nature. 2016 Jul 14;535(7611):252-7. doi: 10.1038/nature18611. Epub 2016 Jun 22. Nature. 2016. PMID: 27338790
Crystallographic studies of the CRBN-DDB1-CC-885-GSPT1 complex reveal that GSPT1 binds to cereblon through a surface turn containing a glycine residue at a key position, interacting with both CC-885 and a 'hotspot' on the cereblon surface. ...
Crystallographic studies of the CRBN-DDB1-CC-885-GSPT1 complex reveal that GSPT1 binds to cereblon through a surface turn containing …
Binding Features and Functions of ATG3.
Fang D, Xie H, Hu T, Shan H, Li M. Fang D, et al. Front Cell Dev Biol. 2021 Jun 21;9:685625. doi: 10.3389/fcell.2021.685625. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34235149 Free PMC article. Review.
Here, we summarize the current knowledge of ATG3 in autophagosome formation, highlight its binding partners and binding sites, review its autophagy-dependent functions, and provide a brief introduction into its autophagy-independent functions....
Here, we summarize the current knowledge of ATG3 in autophagosome formation, highlight its binding partners and binding sites, …
WIPI2 positively regulates mitophagy by promoting mitochondrial recruitment of VCP.
Lu G, Tan HWS, Schmauck-Medina T, Wang L, Chen J, Cho YL, Chen K, Zhang JZ, He W, Wu Y, Xia D, Zhou J, Fang EF, Fang L, Liu W, Shen HM. Lu G, et al. Autophagy. 2022 Dec;18(12):2865-2879. doi: 10.1080/15548627.2022.2052461. Epub 2022 Apr 7. Autophagy. 2022. PMID: 35389758 Free PMC article.
Second, loss of WIPI2 impedes mitochondrial damaging agents-induced mitophagy. Third, at molecular level, WIPI2 binds to and promotes AAA-ATPase VCP/p97 (valosin containing protein) to damaged mitochondria; and WIPI2 depletion blunts the recruitment of VCP to damaged mitoc …
Second, loss of WIPI2 impedes mitochondrial damaging agents-induced mitophagy. Third, at molecular level, WIPI2 binds to and promotes …
The RNA binding protein RALY suppresses p53 activity and promotes lung tumorigenesis.
Hu H, Zhao K, Fang D, Wang Z, Yu N, Yao B, Liu K, Wang F, Mei Y. Hu H, et al. Cell Rep. 2023 Apr 25;42(4):112288. doi: 10.1016/j.celrep.2023.112288. Epub 2023 Mar 22. Cell Rep. 2023. PMID: 36952348 Free article.
However, it is not well understood how the Mdm2-p53 pathway is intricately regulated. Here we report that the RNA binding protein RALY functions as an oncogenic factor in lung cancer. RALY simultaneously binds to Mdm2 and the deubiquitinating enzyme USP7. Via these …
However, it is not well understood how the Mdm2-p53 pathway is intricately regulated. Here we report that the RNA binding protein RAL …
8,947 results