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1981 1
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1990 29
1991 33
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27,807 results

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Page 1
Showing results for binding, zhu
Search for binbin, zhu instead (2 results)
Ythdc2 is an N(6)-methyladenosine binding protein that regulates mammalian spermatogenesis.
Hsu PJ, Zhu Y, Ma H, Guo Y, Shi X, Liu Y, Qi M, Lu Z, Shi H, Wang J, Cheng Y, Luo G, Dai Q, Liu M, Guo X, Sha J, Shen B, He C. Hsu PJ, et al. Cell Res. 2017 Sep;27(9):1115-1127. doi: 10.1038/cr.2017.99. Epub 2017 Aug 15. Cell Res. 2017. PMID: 28809393 Free PMC article.
The biological function of YTHDC2, the final member of the YTH protein family, remains unknown. We report that YTHDC2 selectively binds m(6)A at its consensus motif. YTHDC2 enhances the translation efficiency of its targets and also decreases their mRNA abundance. ...The g …
The biological function of YTHDC2, the final member of the YTH protein family, remains unknown. We report that YTHDC2 selectively binds …
Propofol exerts anti-anhedonia effects via inhibiting the dopamine transporter.
Zhu XN, Li J, Qiu GL, Wang L, Lu C, Guo YG, Yang KX, Cai F, Xu T, Yuan TF, Hu J. Zhu XN, et al. Neuron. 2023 May 17;111(10):1626-1636.e6. doi: 10.1016/j.neuron.2023.02.017. Epub 2023 Mar 13. Neuron. 2023. PMID: 36917979 Free article.
The recreational use of propofol is reported to produce a well-rested feeling and euphoric state; yet, the neural mechanisms underlying such pleasant effects remain unelucidated. Here, we report that propofol actively and directly binds to the dopamine transporter (DAT), b …
The recreational use of propofol is reported to produce a well-rested feeling and euphoric state; yet, the neural mechanisms underlying such …
MG53 preserves mitochondrial integrity of cardiomyocytes during ischemia reperfusion-induced oxidative stress.
Gumpper-Fedus K, Park KH, Ma H, Zhou X, Bian Z, Krishnamurthy K, Sermersheim M, Zhou J, Tan T, Li L, Liu J, Lin PH, Zhu H, Ma J. Gumpper-Fedus K, et al. Redox Biol. 2022 Aug;54:102357. doi: 10.1016/j.redox.2022.102357. Epub 2022 Jun 2. Redox Biol. 2022. PMID: 35679798 Free PMC article.
We hypothesized MG53 could preserve mitochondrial integrity after an ischemic event by binding to the mitochondrial-specific lipid, cardiolipin (CL), for mitochondria protection to prevent mitophagy. ...Fluorescent imaging indicated rhMG53 treatment reduced superoxide gene …
We hypothesized MG53 could preserve mitochondrial integrity after an ischemic event by binding to the mitochondrial-specific lipid, c …
An oncopeptide regulates m6A recognition by the m6A reader IGF2BP1 and tumorigenesis.
Zhu S, Wang JZ, Chen D, He YT, Meng N, Chen M, Lu RX, Chen XH, Zhang XL, Yan GR. Zhu S, et al. Nat Commun. 2020 Apr 3;11(1):1685. doi: 10.1038/s41467-020-15403-9. Nat Commun. 2020. PMID: 32245947 Free PMC article.
Here we discover that the long noncoding RNA (lncRNA) LINC00266-1 encodes a 71-amino acid peptide. The peptide mainly interacts with the RNA-binding proteins, including the m(6)A reader IGF2BP1, and is thus named "RNA-binding regulatory peptide" (RBRP). RBRP bind …
Here we discover that the long noncoding RNA (lncRNA) LINC00266-1 encodes a 71-amino acid peptide. The peptide mainly interacts with the RNA …
SLFN5-mediated chromatin dynamics sculpt higher-order DNA repair topology.
Huang J, Wu C, Kloeber JA, Gao H, Gao M, Zhu Q, Chang Y, Zhao F, Guo G, Luo K, Dai H, Liu S, Huang Q, Kim W, Zhou Q, Zhu S, Wu Z, Tu X, Yin P, Deng M, Wang L, Yuan J, Lou Z. Huang J, et al. Mol Cell. 2023 Apr 6;83(7):1043-1060.e10. doi: 10.1016/j.molcel.2023.02.004. Epub 2023 Feb 27. Mol Cell. 2023. PMID: 36854302 Free PMC article.
Here, we report that SLFN5 is a critical factor for 53BP1 topological arrangement at DSBs. Using super-resolution imaging, we find that SLFN5 binds to 53BP1 chromatin domains to assemble a higher-order microdomain architecture by driving damaged chromatin dynamics at both …
Here, we report that SLFN5 is a critical factor for 53BP1 topological arrangement at DSBs. Using super-resolution imaging, we find that SLFN …
Sex hormone-binding globulin and polycystic ovary syndrome.
Zhu JL, Chen Z, Feng WJ, Long SL, Mo ZC. Zhu JL, et al. Clin Chim Acta. 2019 Dec;499:142-148. doi: 10.1016/j.cca.2019.09.010. Epub 2019 Sep 13. Clin Chim Acta. 2019. PMID: 31525346 Review.
Polycystic ovary syndrome (PCOS), one of the most common endocrine diseases that causes infertility in reproductive women, is characterized by hyperandrogenemia, chronic anovulation, and polycystic ovary morphology (PCOM), and most women with PCOS have metabolic abnormalities. A …
Polycystic ovary syndrome (PCOS), one of the most common endocrine diseases that causes infertility in reproductive women, is characterized …
PD-L1 promotes GSDMD-mediated NET release by maintaining the transcriptional activity of Stat3 in sepsis-associated encephalopathy.
Zhu CL, Xie J, Liu Q, Wang Y, Li HR, Yu CM, Li P, Deng XM, Bian JJ, Wang JF. Zhu CL, et al. Int J Biol Sci. 2023 Feb 27;19(5):1413-1429. doi: 10.7150/ijbs.79913. eCollection 2023. Int J Biol Sci. 2023. PMID: 37056920 Free PMC article.
Then, we find that genetic deletion of neutrophil GSDMD or PD-L1 reduces NET release and improves SAE in murine sepsis model. Finally, in human septic neutrophils, p-Y705-Stat3 binds to PD-L1, promotes PD-L1 nuclear translocation and enhances transcription of the gasdermin …
Then, we find that genetic deletion of neutrophil GSDMD or PD-L1 reduces NET release and improves SAE in murine sepsis model. Finally, in hu …
Targeting ZFP64/GAL-1 axis promotes therapeutic effect of nab-paclitaxel and reverses immunosuppressive microenvironment in gastric cancer.
Zhu M, Zhang P, Yu S, Tang C, Wang Y, Shen Z, Chen W, Liu T, Cui Y. Zhu M, et al. J Exp Clin Cancer Res. 2022 Jan 7;41(1):14. doi: 10.1186/s13046-021-02224-x. J Exp Clin Cancer Res. 2022. PMID: 34996504 Free PMC article.
RESULTS: ZFP64 overexpression was linked with aggressive phenotypes, nab-paclitaxel resistance and served as an independent prognostic factor in GC. As a transcription factor, ZFP64 directly binds to Galectin-1 (GAL-1) promoter and promoted GAL-1 transcription, thus induci …
RESULTS: ZFP64 overexpression was linked with aggressive phenotypes, nab-paclitaxel resistance and served as an independent prognostic facto …
Tail engagement of arrestin at the glucagon receptor.
Chen K, Zhang C, Lin S, Yan X, Cai H, Yi C, Ma L, Chu X, Liu Y, Zhu Y, Han S, Zhao Q, Wu B. Chen K, et al. Nature. 2023 Aug;620(7975):904-910. doi: 10.1038/s41586-023-06420-x. Epub 2023 Aug 9. Nature. 2023. PMID: 37558880 Free PMC article.
Arrestins have pivotal roles in regulating G protein-coupled receptor (GPCR) signalling by desensitizing G protein activation and mediating receptor internalization(1,2). It has been proposed that the arrestin binds to the receptor in two different conformations, 'tail' an …
Arrestins have pivotal roles in regulating G protein-coupled receptor (GPCR) signalling by desensitizing G protein activation and mediating …
Linker Histone in Diseases.
Ye X, Feng C, Gao T, Mu G, Zhu W, Yang Y. Ye X, et al. Int J Biol Sci. 2017 Jul 18;13(8):1008-1018. doi: 10.7150/ijbs.19891. eCollection 2017. Int J Biol Sci. 2017. PMID: 28924382 Free PMC article. Review.
The linker histone is a protein that binds with the nucleosome, which is generally considered to achieve chromatin condensation in the nucleus. ...
The linker histone is a protein that binds with the nucleosome, which is generally considered to achieve chromatin condensation in th …
27,807 results
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