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Page 1
Chemotherapeutic Potential of Monensin as an Anti-microbial Agent.
Rajendran V, Ilamathi HS, Dutt S, Lakshminarayana TS, Ghosh PC. Rajendran V, et al. Curr Top Med Chem. 2018;18(22):1976-1986. doi: 10.2174/1568026619666181129141151. Curr Top Med Chem. 2018. PMID: 30499391 Review.
Monensin is a lipid-soluble naturally occurring bioactive ionophore produced by Streptomyces spp. ...This ionophore can selectively kill pathogens with negligible toxic effect on mammalian cells. In this review, we discuss the therapeutic potential of monensin as a …
Monensin is a lipid-soluble naturally occurring bioactive ionophore produced by Streptomyces spp. ...This ionophore can selectively k …
Ionophores as Potent Anti-malarials: A Miracle in the Making.
Bharti H, Singal A, Raza M, Ghosh PC, Nag A. Bharti H, et al. Curr Top Med Chem. 2019;18(23):2029-2041. doi: 10.2174/1568026619666181129125950. Curr Top Med Chem. 2019. PMID: 30499390 Review.
Several recent reports have highlighted the attractive potential of ionophores such as Monensin, Maduramicin, Valinomycin, etc., that can act against multiple stages of malarial parasite's life cycle. ...
Several recent reports have highlighted the attractive potential of ionophores such as Monensin, Maduramicin, Valinomycin, etc., that …
Preparation and characterization of monensin loaded PLGA nanoparticles: in vitro anti-malarial activity against Plasmodium falciparum.
Surolia R, Pachauri M, Ghosh PC. Surolia R, et al. J Biomed Nanotechnol. 2012 Feb;8(1):172-81. doi: 10.1166/jbn.2012.1366. J Biomed Nanotechnol. 2012. PMID: 22515105
Negatively charged and spherical smooth surfaced nanoparticles of size range between 147-167 nm were obtained. The nanoparticles of monensin-PLGA showed no chemical interaction between monensin and the polymer molecules. The release kinetics in vitro studies exhibit …
Negatively charged and spherical smooth surfaced nanoparticles of size range between 147-167 nm were obtained. The nanoparticles of monen …
Folate receptor mediated targeted delivery of ricin entrapped into sterically stabilized liposomes to human epidermoid carcinoma (KB) cells: effect of monensin intercalated into folate-tagged liposomes.
Tyagi N, Ghosh PC. Tyagi N, et al. Eur J Pharm Sci. 2011 Jul 17;43(4):343-53. doi: 10.1016/j.ejps.2011.05.010. Epub 2011 May 20. Eur J Pharm Sci. 2011. PMID: 21621613
This enhancement of the cytotoxicity of ricin entrapped in folate-targeted liposomes is further enhanced to 557.7-fold by monensin when it was delivered through folate-targeted (0.5 mol% folate-PEG) liposomes. The present study has clearly demonstrated that ricin entrapped …
This enhancement of the cytotoxicity of ricin entrapped in folate-targeted liposomes is further enhanced to 557.7-fold by monensin wh …
Enhancement of the cytotoxicity of liposomal ricin by the carboxylic ionophore monensin and the lysosomotropic amine NH4Cl in Chinese hamster ovary cells.
Bharadwaj S, Rathore SS, Ghosh PC. Bharadwaj S, et al. Int J Toxicol. 2006 Sep-Oct;25(5):349-59. doi: 10.1080/10915810600846195. Int J Toxicol. 2006. PMID: 16940007
This higher level of intracellular liposomal ricin may allow more efficient ricin A-chain release into the cytosol under the influence of NH4Cl and monensin. Monensin-induced potentiation of liposomal ricin was prevented by brefeldin A, indicating that in the presen …
This higher level of intracellular liposomal ricin may allow more efficient ricin A-chain release into the cytosol under the influence of NH …
Enhanced killing of human epidermoid carcinoma (KB) cells by treatment with ricin encapsulated into sterically stabilized liposomes in combination with monensin.
Tyagi N, Rathore SS, Ghosh PC. Tyagi N, et al. Drug Deliv. 2011 Aug;18(6):394-404. doi: 10.3109/10717544.2011.567309. Epub 2011 Mar 26. Drug Deliv. 2011. PMID: 21438723
The maximum cytotoxicity of ricin was observed when it was delivered through negatively charged liposomes having 5 mol% PEG-2000 on the surface. Monensin enhances the cytotoxicity of ricin entrapped in various charged liposomes depending on the surface charge. ...Studies o …
The maximum cytotoxicity of ricin was observed when it was delivered through negatively charged liposomes having 5 mol% PEG-2000 on the surf …
Effect of surface charge and density of distearylphosphatidylethanolamine-mPEG-2000 (DSPE-mPEG-2000) on the cytotoxicity of liposome-entrapped ricin: effect of lysosomotropic agents.
Rathore SS, Ghosh PC. Rathore SS, et al. Int J Pharm. 2008 Feb 28;350(1-2):79-94. doi: 10.1016/j.ijpharm.2007.08.032. Epub 2007 Aug 26. Int J Pharm. 2008. PMID: 17913409
Studies on the effect of variation of density of DSPE-mPEG-2000 on the surface of various charged liposomes on the enhancement of cytotoxicity of entrapped ricin by monensin in CHO pro(-) cells showed that the enhancing potency of monensin on the cytotoxicity of ric …
Studies on the effect of variation of density of DSPE-mPEG-2000 on the surface of various charged liposomes on the enhancement of cytotoxici …