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Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos.
Zuo E, Sun Y, Wei W, Yuan T, Ying W, Sun H, Yuan L, Steinmetz LM, Li Y, Yang H. Zuo E, et al. Science. 2019 Apr 19;364(6437):289-292. doi: 10.1126/science.aav9973. Epub 2019 Feb 28. Science. 2019. PMID: 30819928 Free PMC article.
However, it is difficult to determine off-target effects of editing due to single-nucleotide polymorphism in individuals. Here we developed a method named GOTI (genome-wide off-target analysis by two-cell embryo injection) to detect off-target mutations by editing one blas …
However, it is difficult to determine off-target effects of editing due to single-nucleotide polymorphism in individuals. Here we developed …
GOTI, a method to identify genome-wide off-target effects of genome editing in mouse embryos.
Zuo E, Sun Y, Wei W, Yuan T, Ying W, Sun H, Yuan L, Steinmetz LM, Li Y, Yang H. Zuo E, et al. Nat Protoc. 2020 Sep;15(9):3009-3029. doi: 10.1038/s41596-020-0361-1. Epub 2020 Aug 14. Nat Protoc. 2020. PMID: 32796939 Free PMC article.
GOTI directly compares edited and non-edited cells without the interference of genetic background and thus could detect potential off-target variants with high sensitivity. ...To enhance the utility of GOTI, we also include a computational workflow called GOTI …
GOTI directly compares edited and non-edited cells without the interference of genetic background and thus could detect potential off …
Discrepancies Between Bayesian Vancomycin Models Can Affect Clinical Decisions in the Critically Ill.
Patanwala AE, Spremo D, Jeon M, Thoma Y, C Alffenaar JW, Stocker S. Patanwala AE, et al. Crit Care Res Pract. 2022 Nov 17;2022:7011376. doi: 10.1155/2022/7011376. eCollection 2022. Crit Care Res Pract. 2022. PMID: 36561549 Free PMC article.
AUC(24) values were determined using Tucuxi (revision cd7bd7a8) for dosing intervals with a vancomycin concentration using three models (Goti 2018, Colin 2019, and Thomson 2009) previously evaluated in the critically ill. ...Overall, 52%, 42%, and 47% of the AUC(24) values …
AUC(24) values were determined using Tucuxi (revision cd7bd7a8) for dosing intervals with a vancomycin concentration using three models ( …
Implementing Vancomycin Population Pharmacokinetic Models: An App for Individualized Antibiotic Therapy in Critically Ill Patients.
Mena M, Garcia JC, Bustos RH. Mena M, et al. Antibiotics (Basel). 2023 Feb 2;12(2):301. doi: 10.3390/antibiotics12020301. Antibiotics (Basel). 2023. PMID: 36830212 Free PMC article.
A pragmatic approach was used for selecting the models of Llopis, Goti and Revilla for developing a Shiny app with R. Through ordinary differential equation (ODE)-based mixed effects models from the mlxR package, the app simulates the concentrations' behavior, estimates wh …
A pragmatic approach was used for selecting the models of Llopis, Goti and Revilla for developing a Shiny app with R. Through ordinar …
Pediatric Sickle Cell Disease and Stroke: A Literature Review.
Parikh T, Goti A, Yashi K, Gopalakrishnan Ravikumar NP, Parmar N, Dankhara N, Satodiya V. Parikh T, et al. Cureus. 2023 Jan 20;15(1):e34003. doi: 10.7759/cureus.34003. eCollection 2023 Jan. Cureus. 2023. PMID: 36811060 Free PMC article. Review.
Undetectable off-target effects induced by FokI catalytic domain in mouse embryos.
Xie L, Feng H, Li Z, Li D, Yang X, Yuan T, Yan N, He C, Zheng J, Zuo Z, Zheng Y, Cao Y, Lu Y, Xiong XY, Zuo E. Xie L, et al. Genome Biol. 2024 Feb 20;25(1):51. doi: 10.1186/s13059-024-03188-9. Genome Biol. 2024. PMID: 38378658 Free PMC article.
We use Genome-wide Off-target analysis by Two-cell embryo Injection (GOTI) to detect low-frequency off-target editing events in mouse embryos injected with FokI-based architectures. ...
We use Genome-wide Off-target analysis by Two-cell embryo Injection (GOTI) to detect low-frequency off-target editing events in mouse …
Elective Surgery for Diverticulitis in Swiss Hospitals.
Faes S, Hübner M, Demartines N, Hahnloser D, Martin D; Swiss Snapshot Diverticulitis Group. Faes S, et al. Front Surg. 2021 Oct 12;8:717228. doi: 10.3389/fsurg.2021.717228. eCollection 2021. Front Surg. 2021. PMID: 34712691 Free PMC article.
33 results