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PPARδ activation by bexarotene promotes neuroprotection by restoring bioenergetic and quality control homeostasis.
Sci Transl Med. 2017 Dec 6;9(419):eaal2332. doi: 10.1126/scitranslmed.aal2332.
Sci Transl Med. 2017.
PMID: 29212711
Free PMC article.
PPAR-δ is repressed in Huntington's disease, is required for normal neuronal function and can be targeted therapeutically.
Dickey AS, Pineda VV, Tsunemi T, Liu PP, Miranda HC, Gilmore-Hall SK, Lomas N, Sampat KR, Buttgereit A, Torres MJ, Flores AL, Arreola M, Arbez N, Akimov SS, Gaasterland T, Lazarowski ER, Ross CA, Yeo GW, Sopher BL, Magnuson GK, Pinkerton AB, Masliah E, La Spada AR.
Dickey AS, et al. Among authors: flores al.
Nat Med. 2016 Jan;22(1):37-45. doi: 10.1038/nm.4003. Epub 2015 Dec 7.
Nat Med. 2016.
PMID: 26642438
Free PMC article.
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