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Standardized high-dimensional spectral cytometry protocol and panels for whole blood immune phenotyping in clinical and translational studies.
Dott T, Culina S, Chemali R, Mansour CA, Dubois F, Jagla B, Doisne JM, Rogge L, Huetz F, Jönsson F, Commere PH, Di Santo J, Terrier B, Quintana-Murci L, Duffy D, Hasan M; Milieu Intérieur Consortium. Dott T, et al. Cytometry A. 2024 Feb;105(2):124-138. doi: 10.1002/cyto.a.24801. Epub 2023 Oct 12. Cytometry A. 2024. PMID: 37751141
MI used immunophenotyping of a 1000 healthy donor cohort by flow cytometry as a principal outcome for immune variance at steady state. New generation spectral cytometers now enable high-dimensional immune cell characterization from small sample volumes. ...We have standard …
MI used immunophenotyping of a 1000 healthy donor cohort by flow cytometry as a principal outcome for immune variance at steady state …
Asymptomatic humans transmit dengue virus to mosquitoes.
Duong V, Lambrechts L, Paul RE, Ly S, Lay RS, Long KC, Huy R, Tarantola A, Scott TW, Sakuntabhai A, Buchy P. Duong V, et al. Proc Natl Acad Sci U S A. 2015 Nov 24;112(47):14688-93. doi: 10.1073/pnas.1508114112. Epub 2015 Nov 9. Proc Natl Acad Sci U S A. 2015. PMID: 26553981 Free PMC article.
Risk factors for Plasmodium falciparum gametocyte positivity in a longitudinal cohort.
Grange L, Loucoubar C, Telle O, Tall A, Faye J, Sokhna C, Trape JF, Sakuntabhai A, Bureau JF, Paul R. Grange L, et al. PLoS One. 2015 Apr 1;10(4):e0123102. doi: 10.1371/journal.pone.0123102. eCollection 2015. PLoS One. 2015. PMID: 25830351 Free PMC article.
Transmission of malaria parasites from man to mosquito requires the production of gametocyte stage parasites. Cluster analysis of a 19-year long cohort study for gametocyte carriage revealed spatially defined gametocyte hotspots that occurred during the time when chloroqui …
Transmission of malaria parasites from man to mosquito requires the production of gametocyte stage parasites. Cluster analysis of a 1 …
Impact of changing drug treatment and malaria endemicity on the heritability of malaria phenotypes in a longitudinal family-based cohort study.
Loucoubar C, Goncalves B, Tall A, Sokhna C, Trape JF, Diène Sarr F, Faye J, Badiane A, Ly AB, Diop A, Bar-Hen A, Bureau JF, Sakuntabhai A, Paul R. Loucoubar C, et al. PLoS One. 2011;6(11):e26364. doi: 10.1371/journal.pone.0026364. Epub 2011 Nov 3. PLoS One. 2011. PMID: 22073159 Free PMC article.
Pathogen population structure may impact upon the infectious phenotype, especially with the intense short-term selective pressure that drug treatment exerts on pathogens. Rigorous analysis that accounts for repeated measures and disentangles the influence of genetic and en …
Pathogen population structure may impact upon the infectious phenotype, especially with the intense short-term selective pressure that drug …
Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study.
Ndila CM, Uyoga S, Macharia AW, Nyutu G, Peshu N, Ojal J, Shebe M, Awuondo KO, Mturi N, Tsofa B, Sepúlveda N, Clark TG, Band G, Clarke G, Rowlands K, Hubbart C, Jeffreys A, Kariuki S, Marsh K, Mackinnon M, Maitland K, Kwiatkowski DP, Rockett KA, Williams TN; MalariaGEN Consortium. Ndila CM, et al. Lancet Haematol. 2018 Aug;5(8):e333-e345. doi: 10.1016/S2352-3026(18)30107-8. Epub 2018 Jul 20. Lancet Haematol. 2018. PMID: 30033078 Free PMC article.
We judged p values less than 0.005 significant for the primary analysis of the association between candidate genes and severe malaria. ...Combined, these genetic associations accounted for 5.2% of the variance in risk for developing severe malaria among individuals …
We judged p values less than 0.005 significant for the primary analysis of the association between candidate genes and severe malaria …