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Page 1
Effect of Pd(II) and Ni(II) coordination compounds with 4-amino-3-mercapto-5-methyl-1,2,4-triazole on the mitochondrial dehydrogenases activity.
Orysyk SI, Repich GG, Andrushchenko OO, Nikulina VV, Orysyk VV, Zborovskii YL, Garmanchuk LV, Pekhnyo VI, Skachkova OV, Vovk MV. Orysyk SI, et al. Ukr Biochem J. 2015 Jan-Feb;87(1):64-74. Ukr Biochem J. 2015. PMID: 26036132
Pd(I) and Ni(II) complex compounds: [Pd(AMMT)2]Cl2 (1), [Pd(AMMT)4]Cl2 (2) and [Ni(AMMT)2(H2O)](NO3)2 (3) with 4-amino-3-mercapto-5-methyl-1,2,4-triazole (AMMT) have been synthesized. ...In contrast, the Ni(II) complex (3) and Ni(II) salt (5) do not stimulate …
Pd(I) and Ni(II) complex compounds: [Pd(AMMT)2]Cl2 (1), [Pd(AMMT)4]Cl2 (2) and [Ni(AMMT)2(H2O)](NO3)2 (3) with 4-amino-3-mercapto-5-m …
Synthesis, spectral characterization of novel Pd(II), Pt(II) pi-coordination compounds based on N-allylthioureas. Cytotoxic properties and DNA binding ability.
Repich HH, Orysyk VV, Palchykovska LG, Orysyk SI, Zborovskii YL, Vasylchenko OV, Storozhuk OV, Biluk AA, Nikulina VV, Garmanchuk LV, Pekhnyo VI, Vovk MV. Repich HH, et al. J Inorg Biochem. 2017 Mar;168:98-106. doi: 10.1016/j.jinorgbio.2016.12.004. Epub 2016 Dec 10. J Inorg Biochem. 2017. PMID: 28086144
All compounds showed high affinity to DNA that correlates with observed cytostatic and proapoptotic levels. In general Pd(II) compounds showed higher activity than Pt(II) ones....
All compounds showed high affinity to DNA that correlates with observed cytostatic and proapoptotic levels. In general Pd(II) compoun …
Chan-Evans-Lam N1-(het)arylation and N1-alkеnylation of 4-fluoroalkylpyrimidin-2(1H)-ones.
Tkachuk VM, Lukianov OO, Vovk MV, Gillaizeau I, Sukach VA. Tkachuk VM, et al. Beilstein J Org Chem. 2020 Sep 17;16:2304-2313. doi: 10.3762/bjoc.16.191. eCollection 2020. Beilstein J Org Chem. 2020. PMID: 33014170 Free PMC article.
An efficient C-N bond-forming process is also observed by using boronic acid pinacol esters as coupling partners in the presence of Cu(II) acetate and boric acid. The 4-fluoroalkyl group on the pyrimidine ring significantly assists in the formation of the target N1-substit …
An efficient C-N bond-forming process is also observed by using boronic acid pinacol esters as coupling partners in the presence of Cu(II
Safety and Immunogenicity of Inactivated Whole Virion COVID-19 Vaccine CoviVac in Clinical Trials in 18-60 and 60+ Age Cohorts.
Gordeychuk IV, Kozlovskaya LI, Siniugina AA, Yagovkina NV, Kuzubov VI, Zakharov KA, Volok VP, Dodina MS, Gmyl LV, Korotina NA, Theodorovich RD, Ulitina YI, Vovk DI, Alikova MV, Kataeva AA, Kalenskaya AV, Solovjeva IV, Tivanova EV, Kondrasheva LY, Ploskireva AA, Akimkin VG, Subbotina KA, Ignatyev GM, Korduban AK, Shustova EY, Bayurova EO, Zhitkevich AS, Avdoshina DV, Piniaeva AN, Kovpak AA, Antonova LP, Rogova YV, Shishova AA, Ivin YY, Sotskova SE, Chernov KA, Ipatova EG, Korduban EA, Ishmukhametov AA. Gordeychuk IV, et al. Viruses. 2023 Aug 29;15(9):1828. doi: 10.3390/v15091828. Viruses. 2023. PMID: 37766235 Free PMC article. Clinical Trial.
We present the results of a randomized, double-blind, placebo-controlled, multi-center clinical trial phase I/II of the tolerability, safety, and immunogenicity of the inactivated whole virion concentrated purified coronavirus vaccine CoviVac in volunteers aged 18-60 and o …
We present the results of a randomized, double-blind, placebo-controlled, multi-center clinical trial phase I/II of the tolerability, …
Circulating levels of inflammatory cytokines and angiogenesis-related growth factors in patients with osteoarthritis after COVID-19.
Krenytska D, Strubchevska K, Kozyk M, Vovk T, Halenova T, Kot L, Raksha N, Savchuk O, Falalyeyeva T, Tsyryuk O, Ostapchenko L. Krenytska D, et al. Front Med (Lausanne). 2023 Jul 6;10:1168487. doi: 10.3389/fmed.2023.1168487. eCollection 2023. Front Med (Lausanne). 2023. PMID: 37484856 Free PMC article.
All examined patients were divided into three groups: the Control group included conditionally healthy donors, group OA included patients with knee OA mainly stage II or III and the group of OA and COVID-19 included patients with OA who had COVID-19. ...
All examined patients were divided into three groups: the Control group included conditionally healthy donors, group OA included patients wi …
3-Dialkylamino-1,2,4-triazoles via Zn(II)-Catalyzed Acyl Hydrazide-Dialkylcyanamide Coupling.
Yunusova SN, Bolotin DS, Suslonov VV, Vovk MA, Tolstoy PM, Kukushkin VY. Yunusova SN, et al. ACS Omega. 2018 Jul 3;3(7):7224-7234. doi: 10.1021/acsomega.8b01047. eCollection 2018 Jul 31. ACS Omega. 2018. PMID: 31458884 Free PMC article.
Zinc(II)-catalyzed (10 mol % ZnCl(2)) coupling of acyl hydrazides and dialkylcyanamides in ethanol leads to 3-dialkylamino-1,2,4-triazoles (76-99%; 17 examples). ...Seventeen new 3-NR(2)-1,2,4-triazoles were characterized by HRESI(+)-MS and IR, (1)H, and (13)C{(1)H} NMR sp …
Zinc(II)-catalyzed (10 mol % ZnCl(2)) coupling of acyl hydrazides and dialkylcyanamides in ethanol leads to 3-dialkylamino-1,2,4-tria …
Evaluation of proteolytic activity and serine proteases distribution in plasma from patients with bladder cancer.
Synelnyk T, Vovk T, Halenova T, Tytarenko V, Raksha N, Savchuk O, Falalyeyeva T, Ostapchenko L, Yakovlev P, Kozyk M, Thorley D, Strubchevska K. Synelnyk T, et al. Front Med (Lausanne). 2023 Nov 15;10:1276882. doi: 10.3389/fmed.2023.1276882. eCollection 2023. Front Med (Lausanne). 2023. PMID: 38034543 Free PMC article.
All examined patients were divided into five groups: the control group included conditionally healthy donors, while other patients were grouped according to their tumor stage (I, II, III and IV). Plasma plasminogen levels were determined by enzyme-linked immunosorbent assa …
All examined patients were divided into five groups: the control group included conditionally healthy donors, while other patients were grou …
NMR studies of excluded volume interactions in peptide dendrimers.
Sheveleva NN, Markelov DA, Vovk MA, Mikhailova ME, Tarasenko II, Neelov IM, Lähderanta E. Sheveleva NN, et al. Sci Rep. 2018 Jun 11;8(1):8916. doi: 10.1038/s41598-018-27063-3. Sci Rep. 2018. PMID: 29891953 Free PMC article.
In this paper we focus on the validation of two theoretical assumptions for dendrimers: (i) independence of NMR relaxations on excluded volume effects and (ii) similarity of mobilities of side and terminal segments of dendrimers. ...
In this paper we focus on the validation of two theoretical assumptions for dendrimers: (i) independence of NMR relaxations on excluded volu …
Esterase Activity of Serum Albumin Studied by 1H NMR Spectroscopy and Molecular Modelling.
Belinskaia DA, Voronina PA, Vovk MA, Shmurak VI, Batalova AA, Jenkins RO, Goncharov NV. Belinskaia DA, et al. Int J Mol Sci. 2021 Sep 30;22(19):10593. doi: 10.3390/ijms221910593. Int J Mol Sci. 2021. PMID: 34638934 Free PMC article.
The rate of acetate and propionate release confirms the assumption that there is a site of true esterase activity in the albumin molecule, which is different from the site of the pseudo-esterase activity Sudlow II. The results of molecular modelling of BSA and NPA interact …
The rate of acetate and propionate release confirms the assumption that there is a site of true esterase activity in the albumin molecule, w …
Combined-modality therapy for clinical stage I or II Hodgkin's lymphoma: long-term results of the European Organisation for Research and Treatment of Cancer H7 randomized controlled trials.
Noordijk EM, Carde P, Dupouy N, Hagenbeek A, Krol AD, Kluin-Nelemans JC, Tirelli U, Monconduit M, Thomas J, Eghbali H, Aleman BM, Bosq J, Vovk M, Verschueren TA, Pény AM, Girinsky T, Raemaekers JM, Henry-Amar M. Noordijk EM, et al. J Clin Oncol. 2006 Jul 1;24(19):3128-35. doi: 10.1200/JCO.2005.05.2746. Epub 2006 Jun 5. J Clin Oncol. 2006. PMID: 16754934 Clinical Trial.
The aim of this study was to reduce this toxicity using a combination of low-intensity chemotherapy and involved-field radiotherapy (IF-RT) without jeopardizing disease control. PATIENTS AND METHODS: Patients with stage I or II HL were stratified into two groups, favorable …
The aim of this study was to reduce this toxicity using a combination of low-intensity chemotherapy and involved-field radiotherapy (IF-RT) …
21 results