A directed-overflow and damage-control N-glycosidase in riboflavin biosynthesis.
Frelin O, Huang L, Hasnain G, Jeffryes JG, Ziemak MJ, Rocca JR, Wang B, Rice J, Roje S, Yurgel SN, Gregory JF 3rd, Edison AS, Henry CS, de Crécy-Lagard V, Hanson AD.
Frelin O, et al.
Biochem J. 2015 Feb 15;466(1):137-45. doi: 10.1042/BJ20141237.
Biochem J. 2015.
PMID: 25431972
Free PMC article.
We present cheminformatic, biochemical, genetic and genomic evidence to show that: (i) plant and bacterial COG3236 proteins cleave the N-glycosidic bond of the first two intermediates of riboflavin biosynthesis, yielding relatively innocuous products; (ii) certain COG3236 …
We present cheminformatic, biochemical, genetic and genomic evidence to show that: (i) plant and bacterial COG3236 proteins cleave the N-gly …