A new tridecapeptide with an octaarginine vector has analgesic therapeutic potential and prevents morphine-induced tolerance.
Kashkin VA, Shekunova EV, Titov MI, Eliseev II, Gureev MA, Porozov YB, Makarova MN, Makarov VG.
Kashkin VA, et al.
Peptides. 2018 Jan;99:61-69. doi: 10.1016/j.peptides.2017.11.011. Epub 2017 Nov 24.
Peptides. 2018.
PMID: 29175519
The potency of TDP after i.g. administration was lower than that after i.v. administration but comparable with that of i.g. morphine. In the CCI model, TDP (0.1, 1 and 10mg/kg, i.g.) induced marked analgesia with repeated administration without any signs of tolerance. ...
The potency of TDP after i.g. administration was lower than that after i.v. administration but comparable with that of i.g. morphine. …