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Trans-resveratrol self-nano-emulsifying drug delivery system (SNEDDS) with enhanced bioavailability potential: optimization, pharmacokinetics and in situ single pass intestinal perfusion (SPIP) studies.
Singh G, Pai RS. Singh G, et al. Drug Deliv. 2015;22(4):522-30. doi: 10.3109/10717544.2014.885616. Epub 2014 Feb 11. Drug Deliv. 2015. PMID: 24512464
Augmentation in the values of K(a) (3.29-fold) and AUC (4.31-fold) indicated significant enhancement in the rate and extent of bioavailability by the OPT compared with pure drug. In situ perfusion (SPIP) studies in Wistar rats construed remarkable enhancement in the absorp …
Augmentation in the values of K(a) (3.29-fold) and AUC (4.31-fold) indicated significant enhancement in the rate and extent of bioavailabili …
Atazanavir-loaded Eudragit RL 100 nanoparticles to improve oral bioavailability: optimization and in vitro/in vivo appraisal.
Singh G, Pai RS. Singh G, et al. Drug Deliv. 2016;23(2):532-9. doi: 10.3109/10717544.2014.930760. Epub 2014 Jun 25. Drug Deliv. 2016. PMID: 24963752
Intestinal permeability of OPT formulation was determined using in situ single pass perfusion (SPIP) technique. Transmission electron microscopy studies on OPT formulation demonstrated uniform shape and size of particles. ...Successful establishment of in vitro/in vivo cor …
Intestinal permeability of OPT formulation was determined using in situ single pass perfusion (SPIP) technique. Transmission electron …
Optimized PLGA nanoparticle platform for orally dosed trans-resveratrol with enhanced bioavailability potential.
Singh G, Pai RS. Singh G, et al. Expert Opin Drug Deliv. 2014 May;11(5):647-59. doi: 10.1517/17425247.2014.890588. Epub 2014 Mar 24. Expert Opin Drug Deliv. 2014. PMID: 24661109
The pharmacokinetics, in vivo biodistribution and in situ single-pass intestinal perfusion (SPIP) studies of OPT formulation were investigated in male Wistar rats. ...OPT formulation showed a 2.78-fold rise in the values of t-RVT concentrations in liver. In situ SPIP …
The pharmacokinetics, in vivo biodistribution and in situ single-pass intestinal perfusion (SPIP) studies of OPT formulation were inv …