Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1.
Ehlén Å, Martin C, Miron S, Julien M, Theillet FX, Ropars V, Sessa G, Beaurepere R, Boucherit V, Duchambon P, El Marjou A, Zinn-Justin S, Carreira A.
Ehlén Å, et al.
Nat Commun. 2020 Apr 14;11(1):1819. doi: 10.1038/s41467-020-15689-9.
Nat Commun. 2020.
PMID: 32286328
Free PMC article.
Reducing BRCA2 binding to PLK1, as observed in BRCA2 breast cancer variants S206C and T207A, alters the tetrameric complex resulting in unstable kinetochore-microtubule interactions, misaligned chromosomes, faulty chromosome segregation and aneuploidy. We thus reveal a role of BR …
Reducing BRCA2 binding to PLK1, as observed in BRCA2 breast cancer variants S206C and T207A, alters the tetrameric complex resulting in unst …