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1979 1
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A trial of gantenerumab or solanezumab in dominantly inherited Alzheimer's disease.
Salloway S, Farlow M, McDade E, Clifford DB, Wang G, Llibre-Guerra JJ, Hitchcock JM, Mills SL, Santacruz AM, Aschenbrenner AJ, Hassenstab J, Benzinger TLS, Gordon BA, Fagan AM, Coalier KA, Cruchaga C, Goate AA, Perrin RJ, Xiong C, Li Y, Morris JC, Snider BJ, Mummery C, Surti GM, Hannequin D, Wallon D, Berman SB, Lah JJ, Jimenez-Velazquez IZ, Roberson ED, van Dyck CH, Honig LS, Sánchez-Valle R, Brooks WS, Gauthier S, Galasko DR, Masters CL, Brosch JR, Hsiung GR, Jayadev S, Formaglio M, Masellis M, Clarnette R, Pariente J, Dubois B, Pasquier F, Jack CR Jr, Koeppe R, Snyder PJ, Aisen PS, Thomas RG, Berry SM, Wendelberger BA, Andersen SW, Holdridge KC, Mintun MA, Yaari R, Sims JR, Baudler M, Delmar P, Doody RS, Fontoura P, Giacobino C, Kerchner GA, Bateman RJ; Dominantly Inherited Alzheimer Network–Trials Unit. Salloway S, et al. Nat Med. 2021 Jul;27(7):1187-1196. doi: 10.1038/s41591-021-01369-8. Epub 2021 Jun 21. Nat Med. 2021. PMID: 34155411 Free PMC article. Clinical Trial.
Gantenerumab significantly reduced amyloid plaques, cerebrospinal fluid total tau, and phospho-tau181 and attenuated increases of neurofilament light chain. Amyloid-related imaging abnormalities edema was observed in 19.2% (3 out of 11 were mildly symptomatic) of the gante …
Gantenerumab significantly reduced amyloid plaques, cerebrospinal fluid total tau, and phospho-tau181 and attenuated increases of neurofilam …
Cerebrospinal fluid biomarkers in the Longitudinal Early-onset Alzheimer's Disease Study.
Dage JL, Eloyan A, Thangarajah M, Hammers DB, Fagan AM, Gray JD, Schindler SE, Snoddy C, Nudelman KNH, Faber KM, Foroud T, Aisen P, Griffin P, Grinberg LT, Iaccarino L, Kirby K, Kramer J, Koeppe R, Kukull WA, La Joie R, Mundada NS, Murray ME, Rumbaugh M, Soleimani-Meigooni DN, Toga AW, Touroutoglou A, Vemuri P, Atri A, Beckett LA, Day GS, Graff-Radford NR, Duara R, Honig LS, Jones DT, Masdeu JC, Mendez MF, Musiek E, Onyike CU, Riddle M, Rogalski E, Salloway S, Sha SJ, Turner RS, Wingo TS, Wolk DA, Womack KB, Carrillo MC, Dickerson BC, Rabinovici GD, Apostolova LG; LEADS Consortium. Dage JL, et al. Alzheimers Dement. 2023 Nov;19 Suppl 9(Suppl 9):S115-S125. doi: 10.1002/alz.13399. Epub 2023 Jul 25. Alzheimers Dement. 2023. PMID: 37491668
METHODS: Cerebrospinal fluid (CSF) concentrations of Abeta1-40, Abeta1-42, total tau (tTau), pTau181, VILIP-1, SNAP-25, neurogranin (Ng), neurofilament light chain (NfL), and YKL-40 were measured by immunoassay in 165 LEADS participants. ...
METHODS: Cerebrospinal fluid (CSF) concentrations of Abeta1-40, Abeta1-42, total tau (tTau), pTau181, VILIP-1, SNAP-25, neurogranin (Ng), ne …
Suppression of multiple myeloma by mitochondrial targeting.
Aisen Y, Gatt ME, Hertz R, Smeir E, Bar-Tana J. Aisen Y, et al. Sci Rep. 2021 Mar 12;11(1):5862. doi: 10.1038/s41598-021-83829-2. Sci Rep. 2021. PMID: 33712631 Free PMC article.
MM cell survival may further be suppressed by limiting cellular cholesterol. Long-chain fatty acid analogs of the MEDICA series promote mitochondrial stress and inhibit cholesterol biosynthesis, thus prompting us to verify their efficacy and mode-of-action in suppressing M …
MM cell survival may further be suppressed by limiting cellular cholesterol. Long-chain fatty acid analogs of the MEDICA series promo …
Structural allostery and binding of the transferrin*receptor complex.
Xu G, Liu R, Zak O, Aisen P, Chance MR. Xu G, et al. Mol Cell Proteomics. 2005 Dec;4(12):1959-67. doi: 10.1074/mcp.M500095-MCP200. Epub 2005 Sep 16. Mol Cell Proteomics. 2005. PMID: 16332734 Free article.
In this study we examined the binding interactions of full-length transferrin with receptor and compared these data with a model of the complex derived from cryoelectron microscopy (cryo-EM) reconstructions (Cheng, Y., Zak, O., Aisen, P., Harrison, S. C. & Walz, T. (20 …
In this study we examined the binding interactions of full-length transferrin with receptor and compared these data with a model of the comp …
Longitudinal Associations of Blood Phosphorylated Tau181 and Neurofilament Light Chain With Neurodegeneration in Alzheimer Disease.
Moscoso A, Grothe MJ, Ashton NJ, Karikari TK, Lantero Rodríguez J, Snellman A, Suárez-Calvet M, Blennow K, Zetterberg H, Schöll M; Alzheimer’s Disease Neuroimaging Initiative. Moscoso A, et al. JAMA Neurol. 2021 Apr 1;78(4):396-406. doi: 10.1001/jamaneurol.2020.4986. JAMA Neurol. 2021. PMID: 33427873 Free PMC article.
OBJECTIVE: To study the potential of longitudinal plasma p-tau181 measures for assessing neurodegeneration progression and cognitive decline in AD in comparison to plasma neurofilament light chain (NfL), a disease-nonspecific marker of neuronal injury. DESIGN, SETTING, AND …
OBJECTIVE: To study the potential of longitudinal plasma p-tau181 measures for assessing neurodegeneration progression and cognitive decline …
Directly modelling population dynamics in the South American Arid Diagonal using 14C dates.
Timpson A, Barberena R, Thomas MG, Méndez C, Manning K. Timpson A, et al. Philos Trans R Soc Lond B Biol Sci. 2021 Jan 18;376(1816):20190723. doi: 10.1098/rstb.2019.0723. Epub 2020 Nov 30. Philos Trans R Soc Lond B Biol Sci. 2021. PMID: 33250032 Free PMC article.
We introduce the R package ADMUR which uses a continuous piecewise linear (CPL) model of population change, calculates the model likelihood given a (14)C dataset, estimates credible intervals using Markov chain Monte Carlo, applies a goodness-of-fit test, and uses the Schw …
We introduce the R package ADMUR which uses a continuous piecewise linear (CPL) model of population change, calculates the model likelihood …
Bayesian latent time joint mixed-effects model of progression in the Alzheimer's Disease Neuroimaging Initiative.
Li D, Iddi S, Thompson WK, Rafii MS, Aisen PS, Donohue MC. Li D, et al. Alzheimers Dement (Amst). 2018 Aug 29;10:657-668. doi: 10.1016/j.dadm.2018.07.008. eCollection 2018. Alzheimers Dement (Amst). 2018. PMID: 30456292 Free PMC article.
METHODS: We apply a latent time joint mixed-effects model to 16 cognitive, functional, biomarker, and imaging outcomes in Alzheimer's Disease Neuroimaging Initiative. Markov chain Monte Carlo methods are used for estimation and inference. ...
METHODS: We apply a latent time joint mixed-effects model to 16 cognitive, functional, biomarker, and imaging outcomes in Alzheimer's Diseas …
BACE inhibition causes rapid, regional, and non-progressive volume reduction in Alzheimer's disease brain.
Sur C, Kost J, Scott D, Adamczuk K, Fox NC, Cummings JL, Tariot PN, Aisen PS, Vellas B, Voss T, Mahoney E, Mukai Y, Kennedy ME, Lines C, Michelson D, Egan MF. Sur C, et al. Brain. 2020 Dec 1;143(12):3816-3826. doi: 10.1093/brain/awaa332. Brain. 2020. PMID: 33253354 Free PMC article. Clinical Trial.
Standardized uptake value ratios were generated with subcortical white matter as a reference region. Neurofilament light chain in the CSF was assessed as a biomarker of neurodegeneration. ...There were no significant differences between verubecestat and placebo in changes …
Standardized uptake value ratios were generated with subcortical white matter as a reference region. Neurofilament light chain in the …
A poly-His tag method for obtaining the C-terminal lobe of human transferrin.
Zak O, Aisen P. Zak O, et al. Protein Expr Purif. 2003 Mar;28(1):120-4. doi: 10.1016/s1046-5928(02)00648-4. Protein Expr Purif. 2003. PMID: 12651115
The new procedure is more economical in time and effort than its predecessor, and offers the additional advantage of isolating C-lobe expressed with or without its glycan chains....
The new procedure is more economical in time and effort than its predecessor, and offers the additional advantage of isolating C-lobe expres …
Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial.
Quinn JF, Raman R, Thomas RG, Yurko-Mauro K, Nelson EB, Van Dyck C, Galvin JE, Emond J, Jack CR Jr, Weiner M, Shinto L, Aisen PS. Quinn JF, et al. JAMA. 2010 Nov 3;304(17):1903-11. doi: 10.1001/jama.2010.1510. JAMA. 2010. PMID: 21045096 Free PMC article. Clinical Trial.
CONTEXT: Docosahexaenoic acid (DHA) is the most abundant long-chain polyunsaturated fatty acid in the brain. Epidemiological studies suggest that consumption of DHA is associated with a reduced incidence of Alzheimer disease. ...
CONTEXT: Docosahexaenoic acid (DHA) is the most abundant long-chain polyunsaturated fatty acid in the brain. Epidemiological studies …
16 results