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Deletion of muscle IGF-I transiently impairs growth and progressively disrupts glucose homeostasis in male mice.
Vassilakos G, Lei H, Yang Y, Puglise J, Matheny M, Durzynska J, Ozery M, Bennett K, Spradlin R, Bonanno H, Park S, Ahima RS, Barton ER. Vassilakos G, et al. FASEB J. 2019 Jan;33(1):181-194. doi: 10.1096/fj.201800459R. Epub 2018 Jun 22. FASEB J. 2019. PMID: 29932867 Free PMC article.
We assert that muscle IGF-I independently modulates anabolism and metabolism in an age-dependent manner, thus positioning muscle IGF-I maintenance to be critical for both muscle growth and metabolic homeostasis.-Vassilakos, G., Lei, H., Yang, Y., Puglise, J., Matheny, M., …
We assert that muscle IGF-I independently modulates anabolism and metabolism in an age-dependent manner, thus positioning muscle IGF-I maint …