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Page 1
Design, synthesis and biological activity of novel molecules designed to target PARP and DNA.
Bioorg Med Chem Lett. 2017 Feb 1;27(3):688-694. doi: 10.1016/j.bmcl.2016.09.054. Epub 2016 Sep 22.
Bioorg Med Chem Lett. 2017.
PMID: 28003142
Molecular analysis of the dual targeting of the epidermal growth factor receptor and the O6-methylguanine-DNA methyltransferase with a double arm hybrid molecule.
Rupp M, Mouhri ZS, Williams C, Jean-Claude BJ.
Rupp M, et al. Among authors: mouhri zs.
Oncotarget. 2018 Oct 12;9(80):35041-35055. doi: 10.18632/oncotarget.25120. eCollection 2018 Oct 12.
Oncotarget. 2018.
PMID: 30416678
Free PMC article.
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Positional isomerization of a non-cleavable combi-molecule dramatically altered tumor cell response profile.
Huang Y, Rachid Z, Peyrard L, Senhaji Mouhri Z, Williams C, Jean-Claude BJ.
Huang Y, et al. Among authors: senhaji mouhri z.
Chem Biol Drug Des. 2015 Feb;85(2):153-62. doi: 10.1111/cbdd.12402. Epub 2014 Sep 25.
Chem Biol Drug Des. 2015.
PMID: 25092264
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A type I combi-targeting approach for the design of molecules with enhanced potency against BRCA1/2 mutant- and O6-methylguanine-DNA methyltransferase (mgmt)- expressing tumour cells.
Senhaji Mouhri Z, Goodfellow E, Jean-Claude B.
Senhaji Mouhri Z, et al.
BMC Cancer. 2017 Aug 11;17(1):540. doi: 10.1186/s12885-017-3504-1.
BMC Cancer. 2017.
PMID: 28800752
Free PMC article.
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15N-, 13C- and ¹H-NMR Spectroscopy Characterization and Growth Inhibitory Potency of a Combi-Molecule Synthesized by Acetylation of an Unstable Monoalkyltriazene.
Senhaji Mouhri Z, Goodfellow E, Kelley SP, Stein RS, Rogers RD, J Jean-Claude B.
Senhaji Mouhri Z, et al.
Molecules. 2017 Jul 19;22(7):1183. doi: 10.3390/molecules22071183.
Molecules. 2017.
PMID: 28753938
Free PMC article.
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