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Showing results for zdenek many
Your search for Zdenek Masny retrieved no results
TET protein inhibitors: Potential and limitations.
Kaplánek R, Kejík Z, Hajduch J, Veselá K, Kučnirová K, Skaličková M, Venhauerová A, Hosnedlová B, Hromádka R, Dytrych P, Novotný P, Abramenko N, Antonyová V, Hoskovec D, Babula P, Masařík M, Martásek P, Jakubek M. Kaplánek R, et al. Biomed Pharmacother. 2023 Oct;166:115324. doi: 10.1016/j.biopha.2023.115324. Epub 2023 Aug 18. Biomed Pharmacother. 2023. PMID: 37598475 Free article. Review.
TET proteins (methylcytosine dioxygenases) play an important role in the regulation of gene expression. Dysregulation of their activity is associated with many serious pathogenic states such as oncological diseases. Regulation of their activity by specific inhibitors could …
TET proteins (methylcytosine dioxygenases) play an important role in the regulation of gene expression. Dysregulation of their activity is a …
FAM193A is a positive regulator of p53 activity.
Szwarc MM, Guarnieri AL, Joshi M, Duc HN, Laird MC, Pandey A, Khanal S, Dohm E, Bui AK, Sullivan KD, Galbraith MD, Andrysik Z, Espinosa JM. Szwarc MM, et al. Cell Rep. 2023 Mar 28;42(3):112230. doi: 10.1016/j.celrep.2023.112230. Epub 2023 Mar 9. Cell Rep. 2023. PMID: 36897777 Free PMC article.
Inactivation of the p53 tumor suppressor, either by mutations or through hyperactivation of repressors such as MDM2 and MDM4, is a hallmark of cancer. Although many inhibitors of the p53-MDM2/4 interaction have been developed, such as Nutlin, their therapeutic value is lim …
Inactivation of the p53 tumor suppressor, either by mutations or through hyperactivation of repressors such as MDM2 and MDM4, is a hallmark …
[Etiology and pathogenesis of inflammatory bowel diseases].
Lukáš M. Lukáš M. Vnitr Lek. 2014 Jul-Aug;60(7-8):640-4. Vnitr Lek. 2014. PMID: 25130643 Review. Czech.
Zdenek Maratka has been the first physician, who had brought a new information for the Czech medical community with topic of inflammatory bowel diseases, which had been systematic studied for him. ...Despite the fact that the true origin of ulcerative colitis and Crohns di …
Zdenek Maratka has been the first physician, who had brought a new information for the Czech medical community with topic of inflamma …
Indole scaffolds as a promising class of the aryl hydrocarbon receptor ligands.
Dvořák Z, Poulíková K, Mani S. Dvořák Z, et al. Eur J Med Chem. 2021 Apr 5;215:113231. doi: 10.1016/j.ejmech.2021.113231. Epub 2021 Feb 4. Eur J Med Chem. 2021. PMID: 33582577 Review.
The aryl hydrocarbon receptor (AhR), deemed initially as a xenobiotic sensor, plays multiple physiological roles and is involved in various pathophysiological processes and many diseases' etiology. Therefore, the therapeutic and chemopreventive targeting of AhR is a fundam …
The aryl hydrocarbon receptor (AhR), deemed initially as a xenobiotic sensor, plays multiple physiological roles and is involved in various …
[Genetics of autism].
Sedlácek Z, Havlovicová M, Hrdlicka M. Sedlácek Z, et al. Cas Lek Cesk. 2002 Jun 21;141(12):376-80. Cas Lek Cesk. 2002. PMID: 12238023 Review. Czech.
Nowadays it is completely clear that this disorder has a biological basis and many observations show strong genetic determination of autism. The importance of genetic factors is supported by frequent association of this disorder with known hereditary diseases or with vario …
Nowadays it is completely clear that this disorder has a biological basis and many observations show strong genetic determination of …
Anticoagulant Micrurus venoms: Targets and neutralization.
Dashevsky D, Bénard-Valle M, Neri-Castro E, Youngman NJ, Zdenek CN, Alagón A, Portes-Junior JA, Frank N, Fry BG. Dashevsky D, et al. Toxicol Lett. 2021 Feb 1;337:91-97. doi: 10.1016/j.toxlet.2020.11.010. Epub 2020 Nov 14. Toxicol Lett. 2021. PMID: 33197555
This is consistent with the growing body of results showing that varespladib may be an effective treatment for a wide range of toxicity caused by PLA(2) toxins from many different snake species. Varespladib is a particularly attractive candidate to help alleviate the burde …
This is consistent with the growing body of results showing that varespladib may be an effective treatment for a wide range of toxicity caus …
[Zdenek Maratka and his share in the founding of the Czech Gastroenterological Society and its journal. Gastroenterological Society in Czech and Slovac republics].
Kment M. Kment M. Vnitr Lek. 2014 Jul-Aug;60(7-8):611-6. Vnitr Lek. 2014. PMID: 25130638 Czech.
Zdenek Maratka (1914-2010) was a leading person in a Czech and Slovak gastroenterology in spite of the infavourable approach of the official communist policy to him.. ...As an editor emeritus he supported the quality of the journal by many advices and contributions …
Zdenek Maratka (1914-2010) was a leading person in a Czech and Slovak gastroenterology in spite of the infavourable approach of the o …
Children and Snakebite: Snake Venom Effects on Adult and Paediatric Plasma.
Zdenek CN, Rodrigues CFB, Bourke LA, Tanaka-Azevedo AM, Monagle P, Fry BG. Zdenek CN, et al. Toxins (Basel). 2023 Feb 14;15(2):158. doi: 10.3390/toxins15020158. Toxins (Basel). 2023. PMID: 36828472 Free PMC article.
Snakebite is a globally neglected tropical disease, with coagulation disturbances being the primary pathology of many deadly snake venoms. Age-related differences in human plasma have been abundantly reported, yet the effect that these differences pose regarding snakebite …
Snakebite is a globally neglected tropical disease, with coagulation disturbances being the primary pathology of many deadly snake ve …
Prdm9 deficiency of rat oocytes causes synapsis among non-homologous chromosomes and aneuploidy.
Gasic S, Mihola O, Trachtulec Z. Gasic S, et al. Mamm Genome. 2022 Dec;33(4):590-605. doi: 10.1007/s00335-022-09954-z. Epub 2022 May 20. Mamm Genome. 2022. PMID: 35596034
Fertile control rodents carry pachytene oocytes with synapsed homologous chromosomes and repaired breaks, while sterile Prdm9-deficient mice carry pachytene-like oocytes with many persisting breaks and asynapsed chromosomes. However, most PRDM9-lacking rat oocytes displaye …
Fertile control rodents carry pachytene oocytes with synapsed homologous chromosomes and repaired breaks, while sterile Prdm9-deficient mice …
C-geranylated flavonoids from Paulownia tomentosa Steud. fruit as potential anti-inflammatory agents.
Molčanová L, Treml J, Brezáni V, Maršík P, Kurhan S, Trávníček Z, Uhrin P, Šmejkal K. Molčanová L, et al. J Ethnopharmacol. 2022 Oct 5;296:115509. doi: 10.1016/j.jep.2022.115509. Epub 2022 Jun 24. J Ethnopharmacol. 2022. PMID: 35760257
ETHNOPHARMACOLOGICAL RELEVANCE: Paulownia tomentosa Steud., a traditional Chinese medicinal plant, was used for many centuries in Chinese herbal medicine as a component of remedies for many illnesses, including inflammatory diseases. ...
ETHNOPHARMACOLOGICAL RELEVANCE: Paulownia tomentosa Steud., a traditional Chinese medicinal plant, was used for many centuries in Chi …
27 results