Pyrinadines B-G, new bis-pyridine alkaloids with an azoxy moiety from sponge Cribrochalina sp

Yuuko Kariya; Takaaki Kubota; Jane Fromont; Jun'ichi Kobayashi

doi:10.1016/j.bmc.2006.08.045

Pyrinadines B-G, new bis-pyridine alkaloids with an azoxy moiety from sponge Cribrochalina sp

Bioorg Med Chem. 2006 Dec 15;14(24):8415-9. doi: 10.1016/j.bmc.2006.08.045. Epub 2006 Sep 25.

Authors

Yuuko Kariya¹, Takaaki Kubota, Jane Fromont, Jun'ichi Kobayashi

Affiliation

¹ Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.

PMID: 16997563
DOI: 10.1016/j.bmc.2006.08.045

Abstract

Six new cytotoxic bis-3-alkylpyridine alkaloids with an azoxy moiety, pyrinadines B-G (1-6), have been isolated from an Okinawan marine sponge Cribrochalina sp., and the structures were elucidated by spectroscopic data and chemical means.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alkaloids / chemistry*
Alkaloids / pharmacology
Animals
Antineoplastic Agents / chemistry*
Antineoplastic Agents / pharmacology
Azo Compounds / chemistry*
Humans
KB Cells / drug effects
Leukemia L1210 / drug therapy
Mice
Molecular Structure
Porifera / chemistry*
Pyridines / chemistry*
Pyridines / pharmacology
Tumor Cells, Cultured

Substances

Alkaloids
Antineoplastic Agents
Azo Compounds
Pyridines
pyridine