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Page 1
The primary cause of muscle disfunction associated with substitutions E240K and R244G in tropomyosin is aberrant behavior of tropomyosin and response of actin and myosin during ATPase cycle.
Simonyan AO, Sirenko VV, Karpicheva OE, Robaszkiewicz K, Śliwinska M, Moraczewska J, Krutetskaya ZI, Borovikov YS. Simonyan AO, et al. Among authors: borovikov ys. Arch Biochem Biophys. 2018 Apr 15;644:17-28. doi: 10.1016/j.abb.2018.03.002. Epub 2018 Mar 3. Arch Biochem Biophys. 2018. PMID: 29510086
Deviations in conformational rearrangements of thin filaments and myosin caused by the Ala155Thr substitution in hydrophobic core of tropomyosin.
Karpicheva OE, Sirenko VV, Rysev NA, Simonyan AO, Borys D, Moraczewska J, Borovikov YS. Karpicheva OE, et al. Among authors: borovikov ys. Biochim Biophys Acta Proteins Proteom. 2017 Dec;1865(12):1790-1799. doi: 10.1016/j.bbapap.2017.09.008. Epub 2017 Sep 20. Biochim Biophys Acta Proteins Proteom. 2017. PMID: 28939420
35 results