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Osthole improves an accelerated focal segmental glomerulosclerosis model in the early stage by activating the Nrf2 antioxidant pathway and subsequently inhibiting NF-κB-mediated COX-2 expression and apoptosis.
Yang SM, Chan YL, Hua KF, Chang JM, Chen HL, Tsai YJ, Hsu YJ, Chao LK, Feng-Ling Y, Tsai YL, Wu SH, Wang YF, Tsai CL, Chen A, Ka SM. Yang SM, et al. Among authors: tsai yj. Free Radic Biol Med. 2014 Aug;73:260-9. doi: 10.1016/j.freeradbiomed.2014.05.009. Epub 2014 May 22. Free Radic Biol Med. 2014. PMID: 24858719