Rubellawus A-D, Four New Diterpenoids Isolated from Callicarpa rubella and Their Anti-NLRP3 Inflammasome Effects

Chem Biodivers. 2020 Dec;17(12):e2000798. doi: 10.1002/cbdv.202000798. Epub 2020 Nov 26.

Abstract

Four new diterpenoids, rubellawus A-D (1-4), along with three known compounds, were isolated and identified from the flowers of Callicarpa rubella. Their structures were elucidated by various spectroscopic analysis. All the compounds were screened for their anti-inflammatory activity and 14α-hydroxyisopimaric acid and isopimaric acid showed significant NLRP3 inflammasome inhibitory activity with IC50 values of 7.02 and 3.99 μM.

Keywords: Callicarpa rubella; NLRP3 inflammasome; anti-inflammatory activity; diterpenoids.

MeSH terms

  • Animals
  • Callicarpa / chemistry*
  • Cell Line
  • Diterpenes / chemistry
  • Diterpenes / isolation & purification*
  • Diterpenes / pharmacology*
  • Inflammasomes / antagonists & inhibitors*
  • NLR Family, Pyrin Domain-Containing 3 Protein / antagonists & inhibitors*
  • Spectrum Analysis / methods
  • Structure-Activity Relationship

Substances

  • Diterpenes
  • Inflammasomes
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • NLRP3 protein, human