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Longdan Xiegan Tang attenuates liver injury and hepatic insulin resistance by regulating the angiotensin-converting enzyme 2/Ang (1-7)/Mas axis-mediated anti-inflammatory pathway in rats.
Wang C, Ren L, Chen S, Zheng H, Yang Y, Gu T, Li Y, Wang C. Wang C, et al. J Ethnopharmacol. 2021 Jun 28;274:114072. doi: 10.1016/j.jep.2021.114072. Epub 2021 Mar 26. J Ethnopharmacol. 2021. PMID: 33781876
More importantly, LXT restored the decreases in angiotensin-converting enzyme 2 (ACE2) protein level, and its downstream targets Ang (1-7) content and Mas receptor expression. CONCLUSIONS: The present results demonstrate that LXT attenuates liver injury and hepatic insulin …
More importantly, LXT restored the decreases in angiotensin-converting enzyme 2 (ACE2) protein level, and its downstream targets Ang …
Glycyrrhizic acid restores the downregulated hepatic ACE2 signaling in the attenuation of mouse steatohepatitis.
Zhou L, Chen S, Wei Y, Sun Y, Yang Y, Lin B, Li Y, Wang C. Zhou L, et al. Eur J Pharmacol. 2024 Mar 15;967:176365. doi: 10.1016/j.ejphar.2024.176365. Epub 2024 Feb 3. Eur J Pharmacol. 2024. PMID: 38316247
Its molecular mechanisms of action, however, remain not completely understood. The angiotensin (Ang) converting enzyme (ACE) 2/Ang-(1-7)/Mas axis, regulated by ACE2 through converting Ang II into Ang-(1-7) to activate Mas receptor, counteracts the pro- …
Its molecular mechanisms of action, however, remain not completely understood. The angiotensin (Ang) converting enzyme (ACE) 2/Ang …