Copper-catalyzed C-S direct cross-coupling of thiols with 5-arylpenta-2,4-dienoic acid ethyl ester

Rongrong Cai; Zhuoda Zhou; Qianqian Chai; Yueer Zhu; Runsheng Xu

doi:10.1039/c8ra05311a

Copper-catalyzed C-S direct cross-coupling of thiols with 5-arylpenta-2,4-dienoic acid ethyl ester

RSC Adv. 2018 Jul 27;8(47):26828-26836. doi: 10.1039/c8ra05311a. eCollection 2018 Jul 24.

Authors

Rongrong Cai¹, Zhuoda Zhou¹, Qianqian Chai¹, Yueer Zhu¹, Runsheng Xu¹

Affiliation

¹ Department of Biology and Environment, Jiyang College of Zhejiang A & F University Shaoxing 311800 Zhejiang China 20140041@zafu.edu.cn.

Abstract

A selective copper (Cu)-catalyzed C-S bond direct cross-coupling of thiols with 5-arylpenta-2,4-dienoic acid ethyl ester was developed. Notably, various biologically active 5-phenyl-3-phenylsulfanylpenta-2,4-dienoic acid ethyl ester derivatives were efficiently synthesized under moderate conditions. Finally, a plausible Cu(i)/Cu(iii) reaction mechanism was proposed.