An efficient microwave-assisted Suzuki reaction using a new pyridine-pyrazole/Pd(II) species as catalyst in aqueous media

Molecules. 2013 Jan 25;18(2):1602-12. doi: 10.3390/molecules18021602.

Abstract

A new pyridine-pyrazole N-N ligand has been conveniently synthesized and characterized by ¹H-, ¹³C-NMR, IR spectroscopies, HRMS and X-ray single-crystal crystallography analyses. The ligand adds to palladium(II) under basic conditions to give high yields of an air-stable and water-soluble complex that was fully characterized by NMR and HRMS. The complex was investigated as a catalyst for the Suzuki reaction in aqueous media under microwave irradiation. The compound proved to be an effective catalyst.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Boronic Acids / chemistry
  • Catalysis
  • Chemistry, Organic / methods*
  • Crystallography, X-Ray
  • Ligands
  • Microwaves*
  • Molecular Conformation
  • Palladium / chemistry*
  • Pyrazoles / chemical synthesis
  • Pyrazoles / chemistry*
  • Pyridines / chemical synthesis
  • Pyridines / chemistry*
  • Recycling
  • Solvents / chemistry
  • Spectrophotometry, Ultraviolet
  • Water / chemistry*

Substances

  • Boronic Acids
  • Ligands
  • Pyrazoles
  • Pyridines
  • Solvents
  • Water
  • pyrazole
  • Palladium
  • pyridine