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Year Number of Results
2002 1
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2018 4
2019 2
2020 3
2021 2
2022 1
2023 3
2024 2

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17 results

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Page 1
Reversible 2'-OH acylation enhances RNA stability.
Fang L, Xiao L, Jun YW, Onishi Y, Kool ET. Fang L, et al. Among authors: onishi y. Nat Chem. 2023 Sep;15(9):1296-1305. doi: 10.1038/s41557-023-01246-6. Epub 2023 Jun 26. Nat Chem. 2023. PMID: 37365334
Development of an exon skipping therapy for X-linked Alport syndrome with truncating variants in COL4A5.
Yamamura T, Horinouchi T, Adachi T, Terakawa M, Takaoka Y, Omachi K, Takasato M, Takaishi K, Shoji T, Onishi Y, Kanazawa Y, Koizumi M, Tomono Y, Sugano A, Shono A, Minamikawa S, Nagano C, Sakakibara N, Ishiko S, Aoto Y, Kamura M, Harita Y, Miura K, Kanda S, Morisada N, Rossanti R, Ye MJ, Nozu Y, Matsuo M, Kai H, Iijima K, Nozu K. Yamamura T, et al. Among authors: onishi y. Nat Commun. 2020 Jun 2;11(1):2777. doi: 10.1038/s41467-020-16605-x. Nat Commun. 2020. PMID: 32488001 Free PMC article.
RNA Control via Redox-Responsive Acylation.
Guo J, Chen S, Onishi Y, Shi Q, Song Y, Mei H, Chen L, Kool ET, Zhu RY. Guo J, et al. Among authors: onishi y. Angew Chem Int Ed Engl. 2024 May 21;63(21):e202402178. doi: 10.1002/anie.202402178. Epub 2024 Apr 3. Angew Chem Int Ed Engl. 2024. PMID: 38480851
A splice-switching oligonucleotide treatment ameliorates glycogen storage disease type 1a in mice with G6PC c.648G>T.
Ito K, Tajima G, Kamisato C, Tsumura M, Iwamoto M, Sekiguchi Y, Numata Y, Watanabe K, Yabe Y, Kanki S, Fujieda Y, Goto K, Sogawa Y, Oitate M, Nagase H, Tsuji S, Nishizawa T, Kakuta M, Masuda T, Onishi Y, Koizumi M, Nakamura H, Okada S, Matsuo M, Takaishi K. Ito K, et al. Among authors: onishi y. J Clin Invest. 2023 Dec 1;133(23):e163464. doi: 10.1172/JCI163464. J Clin Invest. 2023. PMID: 37788110 Free PMC article.
Alkylsulfanyl analogs as potent α2δ ligands.
Shimada K, Ohata Y, Kobayashi J, Onishi Y, Kawamura A, Domon Y, Arakawa N, Inoue T, Kitano Y, Matsuda F, Abe Y, Deguchi T. Shimada K, et al. Among authors: onishi y. Bioorg Med Chem Lett. 2018 Jun 15;28(11):2000-2002. doi: 10.1016/j.bmcl.2018.05.006. Epub 2018 May 4. Bioorg Med Chem Lett. 2018. PMID: 29752183
Not all 2',4'-bridged modifications stabilize DNA/RNA duplexes.
Akita T, Tomita-Sudo E, Itoh S, Sakimoto N, Masuda T, Nakamura A, Onishi Y, Koizumi M, Kawakami J. Akita T, et al. Among authors: onishi y. Nucleosides Nucleotides Nucleic Acids. 2024;43(1):57-64. doi: 10.1080/15257770.2023.2232414. Epub 2023 Jul 9. Nucleosides Nucleotides Nucleic Acids. 2024. PMID: 37424260
Enhancing Repair of Oxidative DNA Damage with Small-Molecule Activators of MTH1.
Lee Y, Onishi Y, McPherson L, Kietrys AM, Hebenbrock M, Jun YW, Das I, Adimoolam S, Ji D, Mohsen MG, Ford JM, Kool ET. Lee Y, et al. Among authors: onishi y. ACS Chem Biol. 2022 Aug 19;17(8):2074-2087. doi: 10.1021/acschembio.2c00038. Epub 2022 Jul 13. ACS Chem Biol. 2022. PMID: 35830623
Discovery of DS-6930, a potent selective PPARγ modulator. Part I: Lead identification.
Shinozuka T, Tsukada T, Fujii K, Tokumaru E, Shimada K, Onishi Y, Matsui Y, Wakimoto S, Kuroha M, Ogata T, Araki K, Ohsumi J, Sawamura R, Watanabe N, Yamamoto H, Fujimoto K, Tani Y, Mori M, Tanaka J. Shinozuka T, et al. Among authors: onishi y. Bioorg Med Chem. 2018 Oct 1;26(18):5079-5098. doi: 10.1016/j.bmc.2018.09.006. Epub 2018 Sep 8. Bioorg Med Chem. 2018. PMID: 30241907
17 results