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STING signalling is terminated through ESCRT-dependent microautophagy of vesicles originating from recycling endosomes.
Kuchitsu Y, Mukai K, Uematsu R, Takaada Y, Shinojima A, Shindo R, Shoji T, Hamano S, Ogawa E, Sato R, Miyake K, Kato A, Kawaguchi Y, Nishitani-Isa M, Izawa K, Nishikomori R, Yasumi T, Suzuki T, Dohmae N, Uemura T, Barber GN, Arai H, Waguri S, Taguchi T. Kuchitsu Y, et al. Nat Cell Biol. 2023 Mar;25(3):453-466. doi: 10.1038/s41556-023-01098-9. Epub 2023 Mar 13. Nat Cell Biol. 2023. PMID: 36918692 Free PMC article.
Homeostatic regulation of STING by retrograde membrane traffic to the ER.
Mukai K, Ogawa E, Uematsu R, Kuchitsu Y, Kiku F, Uemura T, Waguri S, Suzuki T, Dohmae N, Arai H, Shum AK, Taguchi T. Mukai K, et al. Among authors: kuchitsu y. Nat Commun. 2021 Jan 4;12(1):61. doi: 10.1038/s41467-020-20234-9. Nat Commun. 2021. PMID: 33397928 Free PMC article.
Single-molecule localization microscopy reveals STING clustering at the trans-Golgi network through palmitoylation-dependent accumulation of cholesterol.
Kemmoku H, Takahashi K, Mukai K, Mori T, Hirosawa KM, Kiku F, Uchida Y, Kuchitsu Y, Nishioka Y, Sawa M, Kishimoto T, Tanaka K, Yokota Y, Arai H, Suzuki KGN, Taguchi T. Kemmoku H, et al. Among authors: kuchitsu y. Nat Commun. 2024 Jan 11;15(1):220. doi: 10.1038/s41467-023-44317-5. Nat Commun. 2024. PMID: 38212328 Free PMC article.
STINGing organelle surface with acid.
Kuchitsu Y, Taguchi T. Kuchitsu Y, et al. EMBO Rep. 2024 Apr;25(4):1708-1710. doi: 10.1038/s44319-024-00120-x. Epub 2024 Mar 19. EMBO Rep. 2024. PMID: 38503877 Free PMC article.
Comprehensive knockout analysis of the Rab family GTPases in epithelial cells.
Homma Y, Kinoshita R, Kuchitsu Y, Wawro PS, Marubashi S, Oguchi ME, Ishida M, Fujita N, Fukuda M. Homma Y, et al. Among authors: kuchitsu y. J Cell Biol. 2019 Jun 3;218(6):2035-2050. doi: 10.1083/jcb.201810134. Epub 2019 May 9. J Cell Biol. 2019. PMID: 31072826 Free PMC article.
12 results