Ruthenium- and Copper-Catalyzed Propargylic Substitution Reactions of Propargylic Alcohol Derivatives with Hydrazones

Shiyao Liu; Yoshiaki Tanabe; Shogo Kuriyama; Ken Sakata; Yoshiaki Nishibayashi

doi:10.1002/chem.202103784

Ruthenium- and Copper-Catalyzed Propargylic Substitution Reactions of Propargylic Alcohol Derivatives with Hydrazones

Chemistry. 2021 Nov 11;27(63):15562. doi: 10.1002/chem.202103784. Epub 2021 Nov 3.

Authors

Shiyao Liu¹, Yoshiaki Tanabe¹, Shogo Kuriyama¹, Ken Sakata², Yoshiaki Nishibayashi¹

Affiliations

¹ Department of Applied Chemistry, School of Engineering, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan.
² Department of Applied Chemistry, School of Faculty of Pharmaceutical Sciences, Toho University, Miyama, Funabashi, Chiba, Japan.

PMID: 34730261
DOI: 10.1002/chem.202103784

Abstract

Invited for the cover of this issue are Ken Sakata, Yoshiaki Nishibayashi, and co-workers at The University of Tokyo and Toho University. The image depicts the propargylic substitution reaction of a propargylic alcohol with an N-monosubstituted hydrazone, where the nucleophilicity of the hydrazone is controlled by the choice of catalytic system. Read the full text of the article at 10.1002/chem.202103287.

MeSH terms

Catalysis
Copper
Humans
Hydrazones
Ruthenium*

Substances

Hydrazones
Copper
Ruthenium