Hepatocyte-specific Sirt6 deficiency impairs ketogenesis.
Chen L, Liu Q, Tang Q, Kuang J, Li H, Pu S, Wu T, Yang X, Li R, Zhang J, Zhang Z, Huang Y, Li Y, Zou M, Jiang W, Li T, Gong M, Zhang L, Wang H, Qu A, Xie W, He J.
Chen L, et al.
J Biol Chem. 2019 Feb 1;294(5):1579-1589. doi: 10.1074/jbc.RA118.005309. Epub 2018 Dec 10.
J Biol Chem. 2019.
PMID: 30530497
Free PMC article.
Here, we demonstrated that Sirt6 functions as a mediator of ketogenesis in response to a fasting and ketogenic diet (KD). The KD-fed hepatocyte-specific Sirt6 deficiency (HKO) mice exhibited impaired ketogenesis, which was due to enhanced Fsp27 (fat-specific induction of p …
Here, we demonstrated that Sirt6 functions as a mediator of ketogenesis in response to a fasting and ketogenic diet (KD). The KD-fed hepatoc …