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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1973 2
1974 2
1975 3
1976 2
1977 2
1978 2
1979 1
1980 3
1981 2
1982 4
1983 3
1984 4
1985 1
1986 2
1987 4
1988 4
1989 9
1990 6
1991 3
1992 1
1993 2
1994 3
1995 3
1996 2
1997 6
1998 7
1999 9
2000 15
2001 8
2002 13
2003 12
2004 23
2005 20
2006 13
2007 20
2008 26
2009 15
2010 27
2011 34
2012 23
2013 26
2014 43
2015 62
2016 42
2017 72
2018 78
2019 74
2020 58
2021 64
2022 40
2023 32
2024 22

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848 results

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Page 1
Showing results for jonathan murine
Search for Yonathan Murin instead (2 results)
The neuroimmunology of social-stress-induced sensitization.
Biltz RG, Sawicki CM, Sheridan JF, Godbout JP. Biltz RG, et al. Nat Immunol. 2022 Nov;23(11):1527-1535. doi: 10.1038/s41590-022-01321-z. Epub 2022 Nov 11. Nat Immunol. 2022. PMID: 36369271 Free PMC article. Review.
Repeated social defeat (RSD) uniquely promotes the convergence of neuronal, central inflammatory (microglial), and peripheral immune (monocyte) pathways, leading to prolonged anxiety, social withdrawal, and cognitive impairment. Moreover, RSD promotes stress sensitization, in whi …
Repeated social defeat (RSD) uniquely promotes the convergence of neuronal, central inflammatory (microglial), and peripheral immune (monocy …
The Role of PPAR-γ in Allergic Disease.
Stark JM, Coquet JM, Tibbitt CA. Stark JM, et al. Curr Allergy Asthma Rep. 2021 Oct 25;21(11):45. doi: 10.1007/s11882-021-01022-x. Curr Allergy Asthma Rep. 2021. PMID: 34697644 Free PMC article. Review.
PPAR-gamma has been found to promote the functions of TH2 cells, type 2 innate lymphoid cells, M2 macrophages and dendritic cells, regulating lipid metabolism and directly inducing effector gene expression. Moreover, preclinical models of allergy in gene-targeted mice have …
PPAR-gamma has been found to promote the functions of TH2 cells, type 2 innate lymphoid cells, M2 macrophages and dendritic cells, regulatin …
Functional aspects of meningeal lymphatics in ageing and Alzheimer's disease.
Da Mesquita S, Louveau A, Vaccari A, Smirnov I, Cornelison RC, Kingsmore KM, Contarino C, Onengut-Gumuscu S, Farber E, Raper D, Viar KE, Powell RD, Baker W, Dabhi N, Bai R, Cao R, Hu S, Rich SS, Munson JM, Lopes MB, Overall CC, Acton ST, Kipnis J. Da Mesquita S, et al. Nature. 2018 Aug;560(7717):185-191. doi: 10.1038/s41586-018-0368-8. Epub 2018 Jul 25. Nature. 2018. PMID: 30046111 Free PMC article.
Here we show that meningeal lymphatic vessels drain macromolecules from the CNS (cerebrospinal and interstitial fluids) into the cervical lymph nodes in mice. Impairment of meningeal lymphatic function slows paravascular influx of macromolecules into the brain and efflux o …
Here we show that meningeal lymphatic vessels drain macromolecules from the CNS (cerebrospinal and interstitial fluids) into the cervical ly …
Novel insights into double-stranded RNA-mediated immunopathology.
de Reuver R, Maelfait J. de Reuver R, et al. Nat Rev Immunol. 2024 Apr;24(4):235-249. doi: 10.1038/s41577-023-00940-3. Epub 2023 Sep 26. Nat Rev Immunol. 2024. PMID: 37752355 Review.
Extensive analyses of the genotype-phenotype relationships in these mice have now firmly established a causal relationship between increased intracellular concentrations of endogenous immunostimulatory dsRNA and type I interferon-driven immunopathology. ...
Extensive analyses of the genotype-phenotype relationships in these mice have now firmly established a causal relationship between in …
Base editing of haematopoietic stem cells rescues sickle cell disease in mice.
Newby GA, Yen JS, Woodard KJ, Mayuranathan T, Lazzarotto CR, Li Y, Sheppard-Tillman H, Porter SN, Yao Y, Mayberry K, Everette KA, Jang Y, Podracky CJ, Thaman E, Lechauve C, Sharma A, Henderson JM, Richter MF, Zhao KT, Miller SM, Wang T, Koblan LW, McCaffrey AP, Tisdale JF, Kalfa TA, Pruett-Miller SM, Tsai SQ, Weiss MJ, Liu DR. Newby GA, et al. Nature. 2021 Jul;595(7866):295-302. doi: 10.1038/s41586-021-03609-w. Epub 2021 Jun 2. Nature. 2021. PMID: 34079130 Free PMC article.
Sixteen weeks after transplantation of edited human HSPCs into immunodeficient mice, the frequency of HBB(G) was 68% and hypoxia-induced sickling of bone marrow reticulocytes had decreased fivefold, indicating durable gene editing. ...Mice that received base-edited …
Sixteen weeks after transplantation of edited human HSPCs into immunodeficient mice, the frequency of HBB(G) was 68% and hypoxia-indu …
ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation.
de Reuver R, Verdonck S, Dierick E, Nemegeer J, Hessmann E, Ahmad S, Jans M, Blancke G, Van Nieuwerburgh F, Botzki A, Vereecke L, van Loo G, Declercq W, Hur S, Vandenabeele P, Maelfait J. de Reuver R, et al. Nature. 2022 Jul;607(7920):784-789. doi: 10.1038/s41586-022-04974-w. Epub 2022 Jul 20. Nature. 2022. PMID: 35859175
In humans, reduced ADAR1 activity causes the severe inflammatory disease Aicardi-Goutieres syndrome (AGS)(2). In mice, complete loss of ADAR1 activity is embryonically lethal(3-6), and mutations similar to those found in patients with AGS cause autoinflammation(7-12). ...Z …
In humans, reduced ADAR1 activity causes the severe inflammatory disease Aicardi-Goutieres syndrome (AGS)(2). In mice, complete loss …
Molecular recording of mammalian embryogenesis.
Chan MM, Smith ZD, Grosswendt S, Kretzmer H, Norman TM, Adamson B, Jost M, Quinn JJ, Yang D, Jones MG, Khodaverdian A, Yosef N, Meissner A, Weissman JS. Chan MM, et al. Nature. 2019 Jun;570(7759):77-82. doi: 10.1038/s41586-019-1184-5. Epub 2019 May 13. Nature. 2019. PMID: 31086336 Free PMC article.
Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy.
Bonazzi S, d'Hennezel E, Beckwith REJ, Xu L, Fazal A, Magracheva A, Ramesh R, Cernijenko A, Antonakos B, Bhang HC, Caro RG, Cobb JS, Ornelas E, Ma X, Wartchow CA, Clifton MC, Forseth RR, Fortnam BH, Lu H, Csibi A, Tullai J, Carbonneau S, Thomsen NM, Larrow J, Chie-Leon B, Hainzl D, Gu Y, Lu D, Meyer MJ, Alexander D, Kinyamu-Akunda J, Sabatos-Peyton CA, Dales NA, Zécri FJ, Jain RK, Shulok J, Wang YK, Briner K, Porter JA, Tallarico JA, Engelman JA, Dranoff G, Bradner JE, Visser M, Solomon JM. Bonazzi S, et al. Cell Chem Biol. 2023 Mar 16;30(3):235-247.e12. doi: 10.1016/j.chembiol.2023.02.005. Epub 2023 Mar 1. Cell Chem Biol. 2023. PMID: 36863346 Free article.
The IKZF2 (Helios) transcription factor plays a crucial role in maintaining function and stability of Treg cells, and IKZF2 deficiency reduces tumor growth in mice. Here we report the discovery of NVP-DKY709, a selective molecular glue degrader of IKZF2 that spares IKZF1/3 …
The IKZF2 (Helios) transcription factor plays a crucial role in maintaining function and stability of Treg cells, and IKZF2 deficiency reduc …
In vivo base editing rescues Hutchinson-Gilford progeria syndrome in mice.
Koblan LW, Erdos MR, Wilson C, Cabral WA, Levy JM, Xiong ZM, Tavarez UL, Davison LM, Gete YG, Mao X, Newby GA, Doherty SP, Narisu N, Sheng Q, Krilow C, Lin CY, Gordon LB, Cao K, Collins FS, Brown JD, Liu DR. Koblan LW, et al. Nature. 2021 Jan;589(7843):608-614. doi: 10.1038/s41586-020-03086-7. Epub 2021 Jan 6. Nature. 2021. PMID: 33408413 Free PMC article.
In vivo base editing rescued the vascular pathology of the mice, preserving vascular smooth muscle cell counts and preventing adventitial fibrosis. A single injection of ABE-expressing AAV9 at postnatal day 14 improved vitality and greatly extended the median lifespan of t …
In vivo base editing rescued the vascular pathology of the mice, preserving vascular smooth muscle cell counts and preventing adventi …
848 results