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Page 1
Showing results for yinxu lu
Search for Yinxi Lu instead (1 results)
Cancer SLC6A6-mediated taurine uptake transactivates immune checkpoint genes and induces exhaustion in CD8+ T cells.
Cao T, Zhang W, Wang Q, Wang C, Ma W, Zhang C, Ge M, Tian M, Yu J, Jiao A, Wang L, Liu M, Wang P, Guo Z, Zhou Y, Chen S, Yin W, Yi J, Guo H, Han H, Zhang B, Wu K, Fan D, Wang X, Nie Y, Lu Y, Zhao X. Cao T, et al. Cell. 2024 Apr 25;187(9):2288-2304.e27. doi: 10.1016/j.cell.2024.03.011. Epub 2024 Apr 1. Cell. 2024. PMID: 38565142
Tumor cells outcompete CD8(+) T cells for taurine by overexpressing SLC6A6, which induces T cell death and malfunction, thereby fueling tumor progression. Mechanistically, taurine deficiency in CD8(+) T cells increases ER stress, promoting ATF4 transcription in a PERK-JAK1 …
Tumor cells outcompete CD8(+) T cells for taurine by overexpressing SLC6A6, which induces T cell death and malfunction, thereby fueling tumo …
Oxidized mitochondrial DNA induces gasdermin D oligomerization in systemic lupus erythematosus.
Miao N, Wang Z, Wang Q, Xie H, Yang N, Wang Y, Wang J, Kang H, Bai W, Wang Y, He R, Yan K, Wang Y, Hu Q, Liu Z, Li F, Wang F, Ginhoux F, Zhang X, Yin J, Lu L, Wang J. Miao N, et al. Nat Commun. 2023 Feb 16;14(1):872. doi: 10.1038/s41467-023-36522-z. Nat Commun. 2023. PMID: 36797275 Free PMC article.
Using the pristane-induced lupus model, we show that disease severity is significantly reduced in mice with neutrophil-specific Gsdmd deficiency or following treatment with the GSDMD inhibitor, disulfiram. ...
Using the pristane-induced lupus model, we show that disease severity is significantly reduced in mice with neutrophil-specific Gsdmd def …
Nanobody: A Small Antibody with Big Implications for Tumor Therapeutic Strategy.
Sun S, Ding Z, Yang X, Zhao X, Zhao M, Gao L, Chen Q, Xie S, Liu A, Yin S, Xu Z, Lu X. Sun S, et al. Int J Nanomedicine. 2021 Mar 22;16:2337-2356. doi: 10.2147/IJN.S297631. eCollection 2021. Int J Nanomedicine. 2021. PMID: 33790553 Free PMC article. Review.
Thus, one of the promising novel developments that may address the deficiency of monoclonal antibody-based therapies is the utilization of nanobodies. ...
Thus, one of the promising novel developments that may address the deficiency of monoclonal antibody-based therapies is the utilizati …
Dual functions of microRNA-17 in maintaining cartilage homeostasis and protection against osteoarthritis.
Zhang Y, Li S, Jin P, Shang T, Sun R, Lu L, Guo K, Liu J, Tong Y, Wang J, Liu S, Wang C, Kang Y, Zhu W, Wang Q, Zhang X, Yin F, Sun YE, Cui L. Zhang Y, et al. Nat Commun. 2022 May 4;13(1):2447. doi: 10.1038/s41467-022-30119-8. Nat Commun. 2022. PMID: 35508470 Free PMC article.
Here we report decreased expression of miR-17 in osteoarthritic chondrocytes and its deficiency contributes to OA progression. Supplementation of exogenous miR-17 or its endogenous induction by growth differentiation factor 5, effectively prevented OA by simultaneously tar …
Here we report decreased expression of miR-17 in osteoarthritic chondrocytes and its deficiency contributes to OA progression. Supple …
An entorhinal-visual cortical circuit regulates depression-like behaviors.
Lu J, Zhang Z, Yin X, Tang Y, Ji R, Chen H, Guang Y, Gong X, He Y, Zhou W, Wang H, Cheng K, Wang Y, Chen X, Xie P, Guo ZV. Lu J, et al. Mol Psychiatry. 2022 Sep;27(9):3807-3820. doi: 10.1038/s41380-022-01540-8. Epub 2022 Apr 6. Mol Psychiatry. 2022. PMID: 35388184
Both chemogenetic inactivation of EntV2M projection neurons and optogenetic inactivation of the projection terminals induced social deficiency, anxiety- and despair-related behaviors in healthy mice. ...
Both chemogenetic inactivation of EntV2M projection neurons and optogenetic inactivation of the projection terminals induced social defic …
Treatment With Niraparib Maintenance Therapy in Patients With Newly Diagnosed Advanced Ovarian Cancer: A Phase 3 Randomized Clinical Trial.
Li N, Zhu J, Yin R, Wang J, Pan L, Kong B, Zheng H, Liu J, Wu X, Wang L, Huang Y, Wang K, Zou D, Zhao H, Wang C, Lu W, Lin A, Lou G, Li G, Qu P, Yang H, Zhang Y, Cai H, Pan Y, Hao M, Liu Z, Cui H, Yang Y, Yao S, Zhen X, Hang W, Hou J, Wang J, Wu L. Li N, et al. JAMA Oncol. 2023 Sep 1;9(9):1230-1237. doi: 10.1001/jamaoncol.2023.2283. JAMA Oncol. 2023. PMID: 37440217 Free PMC article. Clinical Trial.
INTERVENTIONS: Patients were randomized 2:1 to receive niraparib or placebo with ISD (200 mg/d for those with a body weight of <77 kg and/or platelet count of <150 103/muL [to convert to 109/muL, multiply by 1] at baseline; 300 mg/d otherwise) stratified by germline BRCA va …
INTERVENTIONS: Patients were randomized 2:1 to receive niraparib or placebo with ISD (200 mg/d for those with a body weight of <77 kg and …
Long-term Pegylated GH for Children With GH Deficiency: A Large, Prospective, Real-world Study.
Hou L, Huang K, Gong C, Luo F, Wei H, Liang L, Du H, Zhang J, Zhong Y, Chen R, Chen X, Pan J, Jin X, Zeng T, Liao W, Liu D, Lan D, Zhu S, Dong Z, Ma H, Yang Y, Xiong F, Lu P, Cheng S, Gu X, Jin R, Liu Y, Wu J, Xu X, Chen L, Dong Q, Pan H, Su Z, Liu L, Luo X, Ni S, Chen Z, Hu Y, Wang C, Liu J, Liu L, Lu B, Wang X, Wang Y, Yang F, Zhang M, Cao L, Liu G, Yao H, Zhan Y, Dai M, Li G, Li L, Liu Y, Wang K, Xiao Y, Zhang X, Dong J, Gu Z, Ying L, Huang F, Liu Y, Liu Z, Ye J, Zhao D, Hu X, Jiang Z, Ye K, Zhu H, Chen S, Chen X, Wan N, Xu Z, Yin Q, Zhang H, Huang X, Yin J, Zhang H, Li P, Yin P, Fu J, Luo X. Hou L, et al. J Clin Endocrinol Metab. 2023 Jul 14;108(8):2078-2086. doi: 10.1210/clinem/dgad039. J Clin Endocrinol Metab. 2023. PMID: 36669772 Free PMC article.
CONTEXT: The evidence of long-term polyethylene glycol recombinant human GH (PEG-rhGH) in pediatric GH deficiency (GHD) is limited. OBJECTIVE: This study aimed to examine the effectiveness and safety of long-term PEG-rhGH in children with GHD in the real world, as well as …
CONTEXT: The evidence of long-term polyethylene glycol recombinant human GH (PEG-rhGH) in pediatric GH deficiency (GHD) is limited. O …
Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally.
Huang H, Weng H, Zhou K, Wu T, Zhao BS, Sun M, Chen Z, Deng X, Xiao G, Auer F, Klemm L, Wu H, Zuo Z, Qin X, Dong Y, Zhou Y, Qin H, Tao S, Du J, Liu J, Lu Z, Yin H, Mesquita A, Yuan CL, Hu YC, Sun W, Su R, Dong L, Shen C, Li C, Qing Y, Jiang X, Wu X, Sun M, Guan JL, Qu L, Wei M, Müschen M, Huang G, He C, Yang J, Chen J. Huang H, et al. Nature. 2019 Mar;567(7748):414-419. doi: 10.1038/s41586-019-1016-7. Epub 2019 Mar 13. Nature. 2019. PMID: 30867593 Free PMC article.
BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency.
Sun C, Yin J, Fang Y, Chen J, Jeong KJ, Chen X, Vellano CP, Ju Z, Zhao W, Zhang D, Lu Y, Meric-Bernstam F, Yap TA, Hattersley M, O'Connor MJ, Chen H, Fawell S, Lin SY, Peng G, Mills GB. Sun C, et al. Cancer Cell. 2018 Mar 12;33(3):401-416.e8. doi: 10.1016/j.ccell.2018.01.019. Cancer Cell. 2018. PMID: 29533782 Free PMC article.
Poly(ADP-ribose) polymerase inhibitors (PARPi) are selectively active in cells with homologous recombination (HR) deficiency (HRD) caused by mutations in BRCA1, BRCA2, and other pathway members. ...
Poly(ADP-ribose) polymerase inhibitors (PARPi) are selectively active in cells with homologous recombination (HR) deficiency (HRD) ca …
Hepatocellular carcinoma-infiltrating γδ T cells are functionally defected and allogenic Vδ2+ γδ T cell can be a promising complement.
He W, Hu Y, Chen D, Li Y, Ye D, Zhao Q, Lin L, Shi X, Lu L, Yin Z, He X, Gao Y, Wu Y. He W, et al. Clin Transl Med. 2022 Apr;12(4):e800. doi: 10.1002/ctm2.800. Clin Transl Med. 2022. PMID: 35390227 Free PMC article.
Both in vitro and in vivo experiments showed that glutamine deficiency upregulated LAG3 expression. Finally, our results indicated that ex vivo-expanded Vdelta2(+) gammadelta T cells from healthy donor could complement the loss of T cell receptor clonality and effector fun …
Both in vitro and in vivo experiments showed that glutamine deficiency upregulated LAG3 expression. Finally, our results indicated th …
205 results