Wang Ji (1463-1539) was a well-known doctor of the Xin An Medical School in the Ming Dynasty. He and his representative masterpiece Yun Qi Yi Lan are particularly important in the medical history of Yunqi, which refers to the principles of Air (Qi) regulation, influencing almost all life in nature. In terms of the theory "nonresponsive pulse matching the South and the North in the ten Stem years" (Nan Bei Zheng Bu Ying Mai), Wang Ji differentiated and analysed the changes of this theory after the Jin and Yuan Dynasties and traced it back to the classics the Inner canon of Huangdi (Huang Di Nei Jing), based on Su Wen Ru Shi Yun Qi Lun Ao, Huang Di Nei Jing and other relevant reference materials. This paper examined the evolution of the theory of unresponsive pulse in the ancient and modern literature. It was found that after the Song Dynasty, the theory of nonresponsive pulse in the South-North in the ten Stem years was developed into two main schools. One was represented by Cheng Wuji and Liu Wansu, followed with Zhang Jingyue, Li Yanshi, Yao Zhian, Lu Guanquan, Wu Qian, Huang Yuanyu, Xue Fuchen and Zhou Xuehai, who argued that the nonresponsive pulse was determined by the position of Shaoyin. Another was represented by Liu Wenshu, followed with Wang Ji, Li Zhongzi, Zhang Zhicong and Ren Yingqiu, who believed that Shaoyin always stands in the middle, Jueyin and Taiyin are always on the two sides of Shaoyin.
汪机及《运气易览》在运气学说史上具有独特的重要地位。其中对南北政不应脉理论，汪机明辨金元以后理论之流变，依据《内经》及刘温舒《素问入式运气论奥》的相关篇章对该理论进行了探本溯源，务在使其重归经旨。通过对不应脉理论之流变进行古今文献的初步考证，发现南北政不应脉理论在宋代以后有两条主要流变。一条以成无己、刘完素为源头，张景岳、李延昰、姚止庵、陆筦泉、吴谦、黄元御、薛福辰、周学海等为支流，主张“少阴所在为不应”；另一条以刘温舒为源头，汪机、李中梓、张志聪、任应秋等为支流，主张根据“少阴居中，厥阴居右，太阴居左，此不可易也”的方位判断不应脉的左右。.