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Page 1
Showing results for ige fab
Search for Yige Fan instead (1 results)
Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization.
Mitropoulou AN, Ceska T, Heads JT, Beavil AJ, Henry AJ, McDonnell JM, Sutton BJ, Davies AM. Mitropoulou AN, et al. Acta Crystallogr F Struct Biol Commun. 2020 Mar 1;76(Pt 3):116-129. doi: 10.1107/S2053230X20001466. Epub 2020 Mar 2. Acta Crystallogr F Struct Biol Commun. 2020. PMID: 32133997 Free PMC article.
Instead, the Fab alone selectively crystallized in different crystal forms, but their structures revealed intermolecular Fab/Fab interactions that were clearly strong enough to disrupt the Fab/IgE-Fc complexes. Some of these interactions were co …
Instead, the Fab alone selectively crystallized in different crystal forms, but their structures revealed intermolecular Fab/ …
Immunoglobulin G structure and rheumatoid factor epitopes.
Maibom-Thomsen SL, Trier NH, Holm BE, Hansen KB, Rasmussen MI, Chailyan A, Marcatili P, Højrup P, Houen G. Maibom-Thomsen SL, et al. PLoS One. 2019 Jun 14;14(6):e0217624. doi: 10.1371/journal.pone.0217624. eCollection 2019. PLoS One. 2019. PMID: 31199818 Free PMC article.
Antibodies are important for immunity and exist in several classes (IgM, IgD, IgA, IgG, IgE). They are composed of symmetric dimeric molecules with two antigen binding regions (Fab) and a constant part (Fc), usually depicted as Y-shaped molecules. ...Moreover, chemi …
Antibodies are important for immunity and exist in several classes (IgM, IgD, IgA, IgG, IgE). They are composed of symmetric dimeric …
Human Monoclonal IgE Antibodies-a Major Milestone in Allergy.
Smith SA, Chruszcz M, Chapman MD, Pomés A. Smith SA, et al. Curr Allergy Asthma Rep. 2023 Jan;23(1):53-65. doi: 10.1007/s11882-022-01055-w. Epub 2022 Dec 2. Curr Allergy Asthma Rep. 2023. PMID: 36459330 Free PMC article. Review.
Advancements in human hybridoma technologies allow for the generation and molecular definition of naturally occurring allergen-specific human IgE monoclonal antibodies. RECENT FINDINGS: A high-resolution structure of dust mite allergen Der p 2 in complex with Fab of …
Advancements in human hybridoma technologies allow for the generation and molecular definition of naturally occurring allergen-specific huma …
The Fab fragment of anti-IgE Cepsilon2 domain prevents allergic reactions through interacting with IgE-FcepsilonRIalpha complex on rat mast cells.
Hirano T, Koyanagi A, Kotoshiba K, Shinkai Y, Kasai M, Ando T, Kaitani A, Okumura K, Kitaura J. Hirano T, et al. Sci Rep. 2018 Sep 24;8(1):14237. doi: 10.1038/s41598-018-32200-z. Sci Rep. 2018. PMID: 30250145 Free PMC article.
Using flow cytometry analysis, we also found that Fab-6HD5 did not recognize the IgE Cepsilon3 domain containing specific binding sites for FcepsilonRIalpha. Furthermore, deletion-mapping studies revealed that Fab-6HD5 recognized conformational epitopes on th …
Using flow cytometry analysis, we also found that Fab-6HD5 did not recognize the IgE Cepsilon3 domain containing specific bind …
Structure of intact IgE and the mechanism of ligelizumab revealed by electron microscopy.
Jensen RK, Jabs F, Miehe M, Mølgaard B, Pfützner W, Möbs C, Spillner E, Andersen GR. Jensen RK, et al. Allergy. 2020 Aug;75(8):1956-1965. doi: 10.1111/all.14222. Epub 2020 Mar 9. Allergy. 2020. PMID: 32037590
METHODS: Structures of two distinct intact IgE with specificity for cross-reactive carbohydrate determinants and Der p 2 as well as complexes of ligelizumab-Fab with IgE and IgE Fc were assessed by negative stain electron microscopy and solution scatte …
METHODS: Structures of two distinct intact IgE with specificity for cross-reactive carbohydrate determinants and Der p 2 as well as c …
Structure of the omalizumab Fab.
Jensen RK, Plum M, Tjerrild L, Jakob T, Spillner E, Andersen GR. Jensen RK, et al. Acta Crystallogr F Struct Biol Commun. 2015 Apr;71(Pt 4):419-26. doi: 10.1107/S2053230X15004100. Epub 2015 Mar 20. Acta Crystallogr F Struct Biol Commun. 2015. PMID: 25849503 Free PMC article.
Omalizumab is a humanized anti-IgE antibody that inhibits the binding of IgE to its receptors on mast cells and basophils, thus blocking the IgE-mediated release of inflammatory mediators from these cells. ...Functionality of the IgE Fc was proven by E …
Omalizumab is a humanized anti-IgE antibody that inhibits the binding of IgE to its receptors on mast cells and basophils, thu …
The anti-IgE/anti-FcepsilonRIalpha autoantibody network in allergic and autoimmune diseases.
Marone G, Spadaro G, Palumbo C, Condorelli G. Marone G, et al. Clin Exp Allergy. 1999 Jan;29(1):17-27. doi: 10.1046/j.1365-2222.1999.00441.x. Clin Exp Allergy. 1999. PMID: 10051698 Review.
Human basophils and mast cells (FcepsilonRI+ cells) can be activated through immunological interaction with the IgE-FcepsilonRI network. FcepsilonRI+ cells can be triggered by cross-linking between the Fab portions of IgE and multivalent antigens (direct anap …
Human basophils and mast cells (FcepsilonRI+ cells) can be activated through immunological interaction with the IgE-FcepsilonRI netwo …
Structural Aspects of the Allergen-Antibody Interaction.
Pomés A, Mueller GA, Chruszcz M. Pomés A, et al. Front Immunol. 2020 Sep 2;11:2067. doi: 10.3389/fimmu.2020.02067. eCollection 2020. Front Immunol. 2020. PMID: 32983155 Free PMC article. Review.
These state-of-the-art approaches, combined with site-directed mutagenesis, have led to the identification of conformational IgE epitopes. The first structures of an allergen (egg lysozyme) in complex with Fab fragments from IgG antibodies were determined in the 198 …
These state-of-the-art approaches, combined with site-directed mutagenesis, have led to the identification of conformational IgE epit …
The Incredible Adventure of Omalizumab.
Domingo C, Monserrate DR, Sogo A, Mirapeix RM. Domingo C, et al. Int J Mol Sci. 2024 Mar 6;25(5):3056. doi: 10.3390/ijms25053056. Int J Mol Sci. 2024. PMID: 38474304 Free PMC article. Review.
Among the key regions of IgE identified were the FAB (fragment antigen binding) portion that has the ability to capture allergens, and the Cepsilon3 domain, through which IgE binds to its membrane receptor. It was then postulated that blocking IgE at t …
Among the key regions of IgE identified were the FAB (fragment antigen binding) portion that has the ability to capture allerg …
Alpha-Gal-containing biologics and anaphylaxis.
Chinuki Y, Morita E. Chinuki Y, et al. Allergol Int. 2019 Jul;68(3):296-300. doi: 10.1016/j.alit.2019.04.001. Epub 2019 Apr 30. Allergol Int. 2019. PMID: 31053502 Free article. Review.
Research has shown that the principal cause of cetuximab-induced anaphylaxis is anti-oligosaccharide IgE antibodies specific for galactose-alpha-1,3-galactose (alpha-Gal) oligosaccharide present on the mouse-derived Fab portion of the cetuximab heavy chain. Furtherm …
Research has shown that the principal cause of cetuximab-induced anaphylaxis is anti-oligosaccharide IgE antibodies specific for gala …
434 results