During the past decades, the incidence of the most common non-Hodgkin's lymphomas has increased dramatically worldwide. In Egypt, it is the fifth most common cancer in both the sexes. The purpose of this study is to study the problem of non-Hodgkin's lymphomas in Alexandria, Egypt: incidence rates and trend. The method employed was record reviewing for estimation of the annual incidence rates of non-Hodgkin's lymphoma and their trends. The general incidence rate of non-Hodgkin's lymphoma was 5.90 in 1995 and reached 8.99 in 2004, with a peak (9.40) in the year 2002. The male incidence of non-Hodgkin's lymphoma demonstrated an obvious rise from 1995 to 1998, with a slowing from 1999 to 2002, followed by another evident rise from 2003. Women showed an increase in non-Hodgkin's lymphoma incidence rates from 1995 to 2000, then a decline afterwards, till 2004. As regards the population from 15 to 60 years old, there was a rise through the period from 1994 to 1999, then a drop from 2000 to 2004. In the elderly group, the incidence rate was doubled during the 10 years (from 13.36/100 000 in 1995 to 26.65 in 2004). The incidence of non-Hodgkin's lymphoma increased steadily from 1995 to 2004 in Alexandria, particularly in the elderly population. The importance of developing additional strategies for screening and prevention of non-Hodgkin's lymphoma, in this group, on the basis of epidemiological evidences is warranted.