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Showing results for yap i cao
Your search for Yapei Cao retrieved no results
Dopamine receptor D2 antagonism normalizes profibrotic macrophage-endothelial crosstalk in non-alcoholic steatohepatitis.
Qing J, Ren Y, Zhang Y, Yan M, Zhang H, Wu D, Ma Y, Chen Y, Huang X, Wu Q, Mazhar M, Wang L, Liu J, Ding BS, Cao Z. Qing J, et al. J Hepatol. 2022 Feb;76(2):394-406. doi: 10.1016/j.jhep.2021.09.032. Epub 2021 Oct 11. J Hepatol. 2022. PMID: 34648896
Unravelling "context-specific" contributions of YAP in liver repair might help selectively bypass fibrosis and preserve the pro-regenerative YAP function in hepatic diseases. ...To specifically target fibrogenic YAP in macrophages, we utilized a GPCR ligand s …
Unravelling "context-specific" contributions of YAP in liver repair might help selectively bypass fibrosis and preserve the pro-regen …
Current hydrogel advances in physicochemical and biological response-driven biomedical application diversity.
Cao H, Duan L, Zhang Y, Cao J, Zhang K. Cao H, et al. Signal Transduct Target Ther. 2021 Dec 16;6(1):426. doi: 10.1038/s41392-021-00830-x. Signal Transduct Target Ther. 2021. PMID: 34916490 Free PMC article. Review.
These behaviors or events included integrin clustering, focal adhesion (FA) complex accumulation and activation, cytoskeleton rearrangement, protein cyto-nuclei shuttling and activation (e.g., Yes-associated protein (YAP), catenin, etc.), cellular compartment reorganizatio …
These behaviors or events included integrin clustering, focal adhesion (FA) complex accumulation and activation, cytoskeleton rearrangement, …
Harnessing matrix stiffness to engineer a bone marrow niche for hematopoietic stem cell rejuvenation.
Zhang X, Cao D, Xu L, Xu Y, Gao Z, Pan Y, Jiang M, Wei Y, Wang L, Liao Y, Wang Q, Yang L, Xu X, Gao Y, Gao S, Wang J, Yue R. Zhang X, et al. Cell Stem Cell. 2023 Apr 6;30(4):378-395.e8. doi: 10.1016/j.stem.2023.03.005. Cell Stem Cell. 2023. PMID: 37028404 Free article.
Here, we show that matrix stiffness fine-tunes HSC niche factor expression by bone marrow stromal cells (BMSCs). Increased stiffness activates Yap/Taz signaling to promote BMSC expansion upon 2D culture, which is largely reversed by 3D culture in soft gelatin methacrylate …
Here, we show that matrix stiffness fine-tunes HSC niche factor expression by bone marrow stromal cells (BMSCs). Increased stiffness activat …
The alanyl-tRNA synthetase AARS1 moonlights as a lactyltransferase to promote YAP signaling in gastric cancer.
Ju J, Zhang H, Lin M, Yan Z, An L, Cao Z, Geng D, Yue J, Tang Y, Tian L, Chen F, Han Y, Wang W, Zhao S, Jiao S, Zhou Z. Ju J, et al. J Clin Invest. 2024 Mar 21;134(10):e174587. doi: 10.1172/JCI174587. J Clin Invest. 2024. PMID: 38512451 Free PMC article.
Specifically, AARS1 was found to sense intracellular lactate and translocate into the nucleus to lactylate and activate the YAP-TEAD complex; and AARS1 itself was identified as a Hippo target gene that forms a positive-feedback loop with YAP-TEAD to promote gastric …
Specifically, AARS1 was found to sense intracellular lactate and translocate into the nucleus to lactylate and activate the YAP-TEAD …
Macrophage K63-Linked Ubiquitination of YAP Promotes Its Nuclear Localization and Exacerbates Atherosclerosis.
Liu M, Yan M, Lv H, Wang B, Lv X, Zhang H, Xiang S, Du J, Liu T, Tian Y, Zhang X, Zhou F, Cheng T, Zhu Y, Jiang H, Cao Y, Ai D. Liu M, et al. Cell Rep. 2020 Aug 4;32(5):107990. doi: 10.1016/j.celrep.2020.107990. Cell Rep. 2020. PMID: 32755583 Free article.
However, the role of YAP in macrophages during atherosclerosis and its mechanism of YAP activation remain unknown. ...Tumor necrosis factor receptor-associated factor 6 (TRAF6), a downstream effector of interleukin-1beta (IL-1beta), triggers YAP ubiquitinatio …
However, the role of YAP in macrophages during atherosclerosis and its mechanism of YAP activation remain unknown. ...Tumor ne …
HERC3 promotes YAP/TAZ stability and tumorigenesis independently of its ubiquitin ligase activity.
Yuan B, Liu J, Shi A, Cao J, Yu Y, Zhu Y, Zhang C, Qiu Y, Luo H, Shi J, Cao X, Xu P, Shen L, Liang T, Zhao B, Feng XH. Yuan B, et al. EMBO J. 2023 Feb 15;42(4):e111549. doi: 10.15252/embj.2022111549. Epub 2023 Jan 4. EMBO J. 2023. PMID: 36598329 Free PMC article.
YAP/TAZ transcriptional co-activators play pivotal roles in tumorigenesis. ...Expression levels of HERC3 correlate with YAP/TAZ protein levels and expression of YAP/TAZ target genes in breast tumor cells and tissues. ...
YAP/TAZ transcriptional co-activators play pivotal roles in tumorigenesis. ...Expression levels of HERC3 correlate with YAP/TA …
USP10 Promotes Proliferation of Hepatocellular Carcinoma by Deubiquitinating and Stabilizing YAP/TAZ.
Zhu H, Yan F, Yuan T, Qian M, Zhou T, Dai X, Cao J, Ying M, Dong X, He Q, Yang B. Zhu H, et al. Cancer Res. 2020 Jun 1;80(11):2204-2216. doi: 10.1158/0008-5472.CAN-19-2388. Epub 2020 Mar 26. Cancer Res. 2020. PMID: 32217697
However, the regulatory mechanism underpinning aberrant activation of YAP/TAZ in hepatocellular carcinoma remains unclear. In this study, we globally profiled the contribution of deubiquitinating enzymes (DUB) to both transcriptional activity and protein abundance of YA …
However, the regulatory mechanism underpinning aberrant activation of YAP/TAZ in hepatocellular carcinoma remains unclear. In this st …
Yap/Taz regulate alveolar regeneration and resolution of lung inflammation.
LaCanna R, Liccardo D, Zhang P, Tragesser L, Wang Y, Cao T, Chapman HA, Morrisey EE, Shen H, Koch WJ, Kosmider B, Wolfson MR, Tian Y. LaCanna R, et al. J Clin Invest. 2019 Apr 15;129(5):2107-2122. doi: 10.1172/JCI125014. eCollection 2019 Apr 15. J Clin Invest. 2019. PMID: 30985294 Free PMC article.
This increase in AECII activities was correlated with increased nuclear expression of Yap and Taz, the mediators of the Hippo pathway. Mice that lacked Yap/Taz in AECIIs exhibited prolonged inflammatory responses in the lung and were delayed in alveolar epithelial r …
This increase in AECII activities was correlated with increased nuclear expression of Yap and Taz, the mediators of the Hippo pathway …
Mechanosensitive Piezo1 is crucial for periosteal stem cell-mediated fracture healing.
Liu Y, Tian H, Hu Y, Cao Y, Song H, Lan S, Dai Z, Chen W, Zhang Y, Shao Z, Liu Y, Tong W. Liu Y, et al. Int J Biol Sci. 2022 Jun 13;18(10):3961-3980. doi: 10.7150/ijbs.71390. eCollection 2022. Int J Biol Sci. 2022. PMID: 35844802 Free PMC article.
Mechanistically, activation of Piezo1 promotes expression of Yes-associated protein (YAP) and its nuclear localization in PSCs, which in turn increases the expression and nuclear localization of beta-catenin. In detail, YAP directly interacts with beta-catenin in th …
Mechanistically, activation of Piezo1 promotes expression of Yes-associated protein (YAP) and its nuclear localization in PSCs, which …
Hippo component YAP promotes focal adhesion and tumour aggressiveness via transcriptionally activating THBS1/FAK signalling in breast cancer.
Shen J, Cao B, Wang Y, Ma C, Zeng Z, Liu L, Li X, Tao D, Gong J, Xie D. Shen J, et al. J Exp Clin Cancer Res. 2018 Jul 28;37(1):175. doi: 10.1186/s13046-018-0850-z. J Exp Clin Cancer Res. 2018. PMID: 30055645 Free PMC article.
Further experiments reveal that YAP could induce FAK phosphorylation through a TEAD-dependent manner. Using gene expression profiling and bioinformatics analysis, we identify the FAK upstream gene, thrombospondin 1, as a direct transcriptional target of YAP-TEAD. Si …
Further experiments reveal that YAP could induce FAK phosphorylation through a TEAD-dependent manner. Using gene expression profiling …
428 results