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Thymoquinone attenuates inflammation in C. Albicans keratitis by activating Nrf2/HO-1 signaling pathway and reducing fungal load.
Yao H, Hu L, Jiang N, Jiang N, Gao L, Jiang R, Liu X, Zheng W, Zhao G. Yao H, et al. Cytokine. 2023 Dec;172:156375. doi: 10.1016/j.cyto.2023.156375. Epub 2023 Oct 3. Cytokine. 2023. PMID: 37797357
Moreover, TQ demonstrated the ability to reduce the levels of inflammatory factors in HCECs stimulated by C. albicans. Additionally, TQ enhanced the expressions of Nrf2 and HO-1 in mouse corneas. The downregulation of cytokines induced by TQ was reversed upon pretreatment …
Moreover, TQ demonstrated the ability to reduce the levels of inflammatory factors in HCECs stimulated by C. albicans. Additionally, TQ enha …
cis-3-(tert-Butoxy-carbonyl-amino)cyclo-hexa-necarboxylic acid.
Hu Y, Sun X, Guo Y, Yao H. Hu Y, et al. Acta Crystallogr Sect E Struct Rep Online. 2008 Aug 30;64(Pt 9):o1847. doi: 10.1107/S1600536808027098. Acta Crystallogr Sect E Struct Rep Online. 2008. PMID: 21201818 Free PMC article.
The title compound, C(12)H(21)NO(4), a gamma-aminobutyric acid derivative, crystallizes with two mol-ecules in the asymmetric unit. The crystal structure is stabilized by inter-molecular N-HO and O-HO hydrogen bonds, forming a strand. An intramolecular N-HO h …
The title compound, C(12)H(21)NO(4), a gamma-aminobutyric acid derivative, crystallizes with two mol-ecules in the asymmetric unit. The crys …
(S)-4,5-dihydro-2-(2-hydroxy-4-hydroxyphenyl)-4-methyl-4-thiazolecarboxylic acid polyethers: a solution to nephrotoxicity.
Bergeron RJ, Wiegand J, McManis JS, Vinson JR, Yao H, Bharti N, Rocca JR. Bergeron RJ, et al. J Med Chem. 2006 May 4;49(9):2772-83. doi: 10.1021/jm0508944. J Med Chem. 2006. PMID: 16640338 Free PMC article.
On the basis of this finding, a less lipophilic, more water-soluble ligand than 6 was assembled, (S)-4,5-dihydro-2-[2-hydroxy-4-(3,6,9-trioxadecyloxy)phenyl]-4-methyl-4-thiazolecarboxylic acid [(S)-4'-(HO)-DADFT-PE, 11], a polyether analogue, along with its ethyl and isopr …
On the basis of this finding, a less lipophilic, more water-soluble ligand than 6 was assembled, (S)-4,5-dihydro-2-[2-hydroxy-4-(3,6,9-triox …
Polyamine-vectored iron chelators: the role of charge.
Bergeron RJ, Bharti N, Wiegand J, McManis JS, Yao H, Prokai L. Bergeron RJ, et al. J Med Chem. 2005 Jun 16;48(12):4120-37. doi: 10.1021/jm048974f. J Med Chem. 2005. PMID: 15943485
However, this was not the case when the cargo fragments were negatively charged. Metabolic studies of the polyamine-vectored (S)-4'-(HO)-DADFTs in rodents indicated that not only did the expected deaminopropylation step occur, but also a surprisingly high level of oxidativ …
However, this was not the case when the cargo fragments were negatively charged. Metabolic studies of the polyamine-vectored (S)-4'-(HO …