1,1'-(3-methyl-4-phenylthieno[2,3-b]thiophene-2,5-diyl)diethanone as a building block in heterocyclic synthesis. Novel synthesis of some pyrazole and pyrimidine derivatives

Yahia Nasser Mabkhot; Abdullah Mohammed Al-Majid; Assem Barakat; Saeed Alshahrani; Yamin Siddiqui

doi:10.3390/molecules16086502

1,1'-(3-methyl-4-phenylthieno[2,3-b]thiophene-2,5-diyl)diethanone as a building block in heterocyclic synthesis. Novel synthesis of some pyrazole and pyrimidine derivatives

Molecules. 2011 Aug 3;16(8):6502-11. doi: 10.3390/molecules16086502.

Authors

Yahia Nasser Mabkhot¹, Abdullah Mohammed Al-Majid, Assem Barakat, Saeed Alshahrani, Yamin Siddiqui

Affiliation

¹ Department of Chemistry, Faculty of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia. Yahia@ksu.edu.sa

Abstract

A series of new bis(heterocycles) featuring thieno[2,3-b]thiophene rings was synthesized in a combinatorial manner. Intramolecular cyclization of enaminone derivatives with appropriate N-nucleophiles afforded the target compounds. All compounds were characterized by ¹H-, ¹³C-NMR, GCMS, IR, and UV-Vis spectrometry. These compounds represent a new class of sulfur- and nitrogen-containing heterocycles that should also be of interest as new materials.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biological Products / chemical synthesis*
Chemistry, Pharmaceutical / methods*
Combinatorial Chemistry Techniques*
Cyclization
Magnetic Resonance Spectroscopy
Nitrogen / chemistry
Pyrazoles / chemical synthesis*
Pyrimidines / chemical synthesis*
Sulfur / chemistry
Thiophenes / chemistry

Substances

Biological Products
Pyrazoles
Pyrimidines
Thiophenes
Sulfur
Nitrogen