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A multivalent Ara-C-prodrug nanoconjugate achieves selective ablation of leukemic cells in an acute myeloid leukemia mouse model.
Pallarès V, Unzueta U, Falgàs A, Aviñó A, Núñez Y, García-León A, Sánchez-García L, Serna N, Gallardo A, Alba-Castellón L, Álamo P, Sierra J, Cedó L, Eritja R, Villaverde A, Vázquez E, Casanova I, Mangues R. Pallarès V, et al. Among authors: nunez y. Biomaterials. 2022 Jan;280:121258. doi: 10.1016/j.biomaterials.2021.121258. Epub 2021 Nov 24. Biomaterials. 2022. PMID: 34847435 Free article.
Antineoplastic effect of a diphtheria toxin-based nanoparticle targeting acute myeloid leukemia cells overexpressing CXCR4.
Pallarès V, Núñez Y, Sánchez-García L, Falgàs A, Serna N, Unzueta U, Gallardo A, Alba-Castellón L, Álamo P, Sierra J, Villaverde A, Vázquez E, Casanova I, Mangues R. Pallarès V, et al. Among authors: nunez y. J Control Release. 2021 Jul 10;335:117-129. doi: 10.1016/j.jconrel.2021.05.014. Epub 2021 May 15. J Control Release. 2021. PMID: 34004204
A diphtheria toxin-based nanoparticle achieves specific cytotoxic effect on CXCR4+ lymphoma cells without toxicity in immunocompromised and immunocompetent mice.
Falgàs A, Garcia-León A, Núñez Y, Serna N, Sánchez-Garcia L, Unzueta U, Voltà-Durán E, Aragó M, Álamo P, Alba-Castellón L, Sierra J, Gallardo A, Villaverde A, Vázquez E, Mangues R, Casanova I. Falgàs A, et al. Among authors: nunez y. Biomed Pharmacother. 2022 Jun;150:112940. doi: 10.1016/j.biopha.2022.112940. Epub 2022 Apr 11. Biomed Pharmacother. 2022. PMID: 35421785 Free article.
Loss of the EPH receptor B6 contributes to colorectal cancer metastasis.
Mateo-Lozano S, Bazzocco S, Rodrigues P, Mazzolini R, Andretta E, Dopeso H, Fernández Y, Del Llano E, Bilic J, Suárez-López L, Macaya I, Cartón-García F, Nieto R, Jimenez-Flores LM, de Marcondes PG, Nuñez Y, Afonso E, Cacci K, Hernández-Losa J, Landolfi S, Abasolo I, Ramón Y Cajal S, Mariadason JM, Schwartz S Jr, Matsui T, Arango D. Mateo-Lozano S, et al. Among authors: nunez y. Sci Rep. 2017 Mar 6;7:43702. doi: 10.1038/srep43702. Sci Rep. 2017. PMID: 28262839 Free PMC article.