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The Application of Ferroptosis in Diseases.
Qiu Y, Cao Y, Cao W, Jia Y, Lu N. Qiu Y, et al. Pharmacol Res. 2020 Sep;159:104919. doi: 10.1016/j.phrs.2020.104919. Epub 2020 May 25. Pharmacol Res. 2020. PMID: 32464324 Review.
Ferroptosis is a new kind of regulated cell death that is characterized by highly iron-dependent lipid peroxidation. Ferroptosis involves various biology processes, such as iron metabolism, lipid metabolism, oxidative stress and biosynthesis of nicotinamide adenine …
Ferroptosis is a new kind of regulated cell death that is characterized by highly iron-dependent lipid peroxidation. Ferroptosis invo …
Iron Metabolism and Ferroptosis in Physiological and Pathological Pregnancy.
Zhang Y, Lu Y, Jin L. Zhang Y, et al. Int J Mol Sci. 2022 Aug 20;23(16):9395. doi: 10.3390/ijms23169395. Int J Mol Sci. 2022. PMID: 36012659 Free PMC article. Review.
Iron is a vital element in nearly every living organism. During pregnancy, optimal iron concentration is essential for both maternal health and fetal development. ...Like most other nutrients, iron exhibits a U-shaped risk curve. Apart from iron defici …
Iron is a vital element in nearly every living organism. During pregnancy, optimal iron concentration is essential for both ma …
The diversified role of mitochondria in ferroptosis in cancer.
Liu Y, Lu S, Wu LL, Yang L, Yang L, Wang J. Liu Y, et al. Cell Death Dis. 2023 Aug 14;14(8):519. doi: 10.1038/s41419-023-06045-y. Cell Death Dis. 2023. PMID: 37580393 Free PMC article. Review.
Ferroptosis is a form of regulated cell death induced by iron-dependent lipid peroxidation, and it has been studied extensively since its discovery in 2012. Induced by iron overload and ROS accumulation, ferroptosis is modulated by various cellular metabolic and sig …
Ferroptosis is a form of regulated cell death induced by iron-dependent lipid peroxidation, and it has been studied extensively since …
HDM induce airway epithelial cell ferroptosis and promote inflammation by activating ferritinophagy in asthma.
Zeng Z, Huang H, Zhang J, Liu Y, Zhong W, Chen W, Lu Y, Qiao Y, Zhao H, Meng X, Zou F, Cai S, Dong H. Zeng Z, et al. FASEB J. 2022 Jun;36(6):e22359. doi: 10.1096/fj.202101977RR. FASEB J. 2022. PMID: 35621121
Ferroptosis is a novel form of regulated cell death mediated by lipid peroxidation in association with free iron-mediated Fenton reactions. In this study, we explored the contribution of ferroptosis to house dust mite (HDM)-induced asthma models. Our in vivo and in vitro m …
Ferroptosis is a novel form of regulated cell death mediated by lipid peroxidation in association with free iron-mediated Fenton reac …
Cadmium induces ferroptosis mediated inflammation by activating Gpx4/Ager/p65 axis in pancreatic β-cells.
Hong H, Lin X, Xu Y, Tong T, Zhang J, He H, Yang L, Lu Y, Zhou Z. Hong H, et al. Sci Total Environ. 2022 Nov 25;849:157819. doi: 10.1016/j.scitotenv.2022.157819. Epub 2022 Aug 2. Sci Total Environ. 2022. PMID: 35931150
Moreover, ferroptosis inhibitor Fer-1 could effectively antagonized the activation of Ager-mediated immune process. It was also revealed that Cd induced iron accumulation as well as decreased Gpx4 expression in mice islets. ...
Moreover, ferroptosis inhibitor Fer-1 could effectively antagonized the activation of Ager-mediated immune process. It was also revealed tha …
Novel Insight into Ferroptosis in Kidney Diseases.
Yang L, Liu Y, Zhou S, Feng Q, Lu Y, Liu D, Liu Z. Yang L, et al. Am J Nephrol. 2023;54(5-6):184-199. doi: 10.1159/000530882. Epub 2023 May 5. Am J Nephrol. 2023. PMID: 37231767 Free article. Review.
BACKGROUND: Various kidney diseases such as acute kidney injury, chronic kidney disease, polycystic kidney disease, renal cancer, and kidney stones, are an important part of the global burden, bringing a huge economic burden to people around the world. Ferroptosis is a type of no …
BACKGROUND: Various kidney diseases such as acute kidney injury, chronic kidney disease, polycystic kidney disease, renal cancer, and kidney …
The role of lactoferrin in atherosclerosis.
Chen C, Lu M, Zhang Z, Qin L. Chen C, et al. Biometals. 2023 Jun;36(3):509-519. doi: 10.1007/s10534-022-00441-1. Epub 2022 Sep 2. Biometals. 2023. PMID: 36053470 Review.
Early prevention, diagnosis, and treatment are promising approaches for stemming the development and progression of AS. Lactoferrin (Lf) is an iron-binding glycoprotein belonging to the transferrin family. It is widely found in body fluids such as digestive tract fluids, t …
Early prevention, diagnosis, and treatment are promising approaches for stemming the development and progression of AS. Lactoferrin (Lf) is …
An Overview of Heavy Chain Ferritin in Cancer.
Shi X, Zhang A, Lu J, Wang X, Yi C, Yang F. Shi X, et al. Front Biosci (Landmark Ed). 2023 Aug 28;28(8):182. doi: 10.31083/j.fbl2808182. Front Biosci (Landmark Ed). 2023. PMID: 37664922 Free article. Review.
As a spherical protein that acts as a repository for intracellular iron, Ferritin is the most important iron storage form and is known to influence tumor immunity. ...
As a spherical protein that acts as a repository for intracellular iron, Ferritin is the most important iron storage form and …
Ferroptosis as a mechanism of non-ferrous metal toxicity.
Aschner M, Skalny AV, Martins AC, Sinitskii AI, Farina M, Lu R, Barbosa F Jr, Gluhcheva YG, Santamaria A, Tinkov AA. Aschner M, et al. Arch Toxicol. 2022 Sep;96(9):2391-2417. doi: 10.1007/s00204-022-03317-y. Epub 2022 Jun 21. Arch Toxicol. 2022. PMID: 35727353 Review.
Given that the toxicity elicited by some metals is linked to alterations in iron metabolism and induction of oxidative stress and lipid peroxidation, ferroptosis might be involved in such toxicity. ...Specifically, the mechanisms underlying metal-induced ferroptosis includ …
Given that the toxicity elicited by some metals is linked to alterations in iron metabolism and induction of oxidative stress and lip …
Ferroptosis increases obesity: Crosstalk between adipocytes and the neuroimmune system.
Zhang S, Sun Z, Jiang X, Lu Z, Ding L, Li C, Tian X, Wang Q. Zhang S, et al. Front Immunol. 2022 Nov 21;13:1049936. doi: 10.3389/fimmu.2022.1049936. eCollection 2022. Front Immunol. 2022. PMID: 36479119 Free PMC article. Review.
Ferroptosis requires not only the accumulation of iron ions, but also changes in many ferroptosis-related regulators, including a decrease in GPX4 and inhibition of SLC7A11 for classical ferroptosis, a deletion of FSP1 or GCH1. ...On the immune side, obesity may cause M2 m …
Ferroptosis requires not only the accumulation of iron ions, but also changes in many ferroptosis-related regulators, including a dec …
3,416 results