Antibacterial stilbenes from the tubers of Bletilla striata

Fitoterapia. 2019 Oct:138:104350. doi: 10.1016/j.fitote.2019.104350. Epub 2019 Aug 30.

Abstract

Three new bibenzyl derivatives (bletstrins A-C, 1-3), including two bibenzyls that have hydroxyl-substituted chiral centers on the aliphatic bibenzyl bridge, along with eighteen known stilbenoids (4-21) were isolated from the tubers of Bletilla striata. The structures of new compounds were elucidated by the use of 1D/2D NMR spectroscopic data. The absolute configurations of bletitrins A and B were determined by optical rotation value. Compounds 13-16 were isolated from the Orchidaceae for the first time. Most of the isolated compounds were evaluated for their antibacterial activities against three gram-positive bacterial strains and one gram-negative bacterial strain. Compounds 4, 10, 12, 14, 15, 16 and 18 showed potent inhibitory activities, with MICs of (6-52 μg/mL) against S. aureus ATCC 6538.

Keywords: Antibacterial activities; Bibenzyls; Bletilla striata; Phenanthrenes; Stilbenoids.

MeSH terms

  • Anti-Bacterial Agents / isolation & purification
  • Anti-Bacterial Agents / pharmacology*
  • Bibenzyls / isolation & purification
  • Bibenzyls / pharmacology
  • China
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Orchidaceae / chemistry*
  • Phytochemicals / isolation & purification
  • Phytochemicals / pharmacology
  • Plant Tubers / chemistry*
  • Staphylococcus aureus / drug effects
  • Stilbenes / isolation & purification
  • Stilbenes / pharmacology*

Substances

  • Anti-Bacterial Agents
  • Bibenzyls
  • Phytochemicals
  • Stilbenes