Why all MODY variants are dominantly inherited: a hypothesis

Trends Genet. 2022 Apr;38(4):321-324. doi: 10.1016/j.tig.2021.10.001. Epub 2021 Oct 22.

Abstract

Maturity-onset diabetes in the young (MODY) comprises monogenic phenotypes of young-onset, insulinopenic diabetes. All its forms are dominantly inherited. Why? Are the pancreatic β cells only harmed by heterozygous variants? We propose that recessive MODYs do exist but have escaped detection due to lack of family history suggestive of monogenic inheritance.

Keywords: diabetes; family history; monogenic; polygenic; recessive MODY.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Diabetes Mellitus, Type 2* / genetics
  • Humans
  • Insulin-Secreting Cells*
  • Mutation
  • Phenotype

Supplementary concepts

  • Mason-Type Diabetes