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Gut microbiota-based metabolites of Xiaoyao Pills (a typical Traditional Chinese medicine) ameliorate depression by inhibiting fatty acid amide hydrolase levels in brain.
Zhang ZW, Han P, Fu J, Yu H, Xu H, Hu JC, Lu JY, Yang XY, Zhang HJ, Bu MM, Jiang JD, Wang Y. Zhang ZW, et al. J Ethnopharmacol. 2023 Sep 15;313:116555. doi: 10.1016/j.jep.2023.116555. Epub 2023 Apr 25. J Ethnopharmacol. 2023. PMID: 37100263
ETHNOPHARMACOLOGICAL RELEVANCE: Traditional Chinese medicines (TCMs) are often prepared in oral dosage forms, making TCMs interact with gut microbiota after oral administration, which could affect the therapeutic effect of TCM. Xiaoyao Pills (XYPs) are a commonly used TCM …
ETHNOPHARMACOLOGICAL RELEVANCE: Traditional Chinese medicines (TCMs) are often prepared in oral dosage forms, making TCMs interact with gut …
Xiaoyao pill for treatment of functional dyspepsia in perimenopausal women with depression.
Du HG, Ming L, Chen SJ, Li CD. Du HG, et al. World J Gastroenterol. 2014 Nov 28;20(44):16739-44. doi: 10.3748/wjg.v20.i44.16739. World J Gastroenterol. 2014. PMID: 25469046 Free PMC article. Clinical Trial.
AIM: To evaluate the efficacy and safety of the Xiaoyao pill for treatment of functional dyspepsia (FD) associated with perimenopausal depression. ...CONCLUSION: The Xiaoyao pill is effective and safe for the treatment of perimenopausal women with FD associated with …
AIM: To evaluate the efficacy and safety of the Xiaoyao pill for treatment of functional dyspepsia (FD) associated with perimenopausa …
Tiaogan Jiejiu Tongluo Formula attenuated alcohol-induced chronic liver injury by regulating lipid metabolism in rats.
Fang C, Zhang J, Han J, Lei Y, Cao Z, Pan J, Pan Z, Zhang Z, Qu N, Luo H, Ma Y, Han D. Fang C, et al. J Ethnopharmacol. 2023 Dec 5;317:116838. doi: 10.1016/j.jep.2023.116838. Epub 2023 Jun 22. J Ethnopharmacol. 2023. PMID: 37355081
ETHNOPHARMACOLOGICAL RELEVANCE: Tiaogan Jiejiu Tongluo Formula (TJTF), a traditional Chinese medicine formula, is modified from the well-known ancient prescription Danzhi-Xiaoyao Powder (DXP). Owing to its ability to regulate liver, strengthen spleen, detoxicating, and dre …
ETHNOPHARMACOLOGICAL RELEVANCE: Tiaogan Jiejiu Tongluo Formula (TJTF), a traditional Chinese medicine formula, is modified from the well-kno …
An Herbal Formulation of Jiawei Xiaoyao for the Treatment of Functional Dyspepsia: A Multicenter, Randomized, Placebo-Controlled, Clinical Trial.
Chen G, Feng P, Wang S, Ding X, Xiong J, Wu J, Wang L, Chen W, Chen G, Han M, Zou T, Li L, Du H. Chen G, et al. Clin Transl Gastroenterol. 2020 Oct;11(10):e00241. doi: 10.14309/ctg.0000000000000241. Clin Transl Gastroenterol. 2020. PMID: 33108123 Free PMC article. Clinical Trial.
INTRODUCTION: To investigate the efficacy and safety of an herbal formulation of Jiawei Xiaoyao (JX) on gastrointestinal symptoms in patients with functional dyspepsia (FD) who had previously rejected standard therapies of proton pump inhibitors, H2 blockers, or Helicobact …
INTRODUCTION: To investigate the efficacy and safety of an herbal formulation of Jiawei Xiaoyao (JX) on gastrointestinal symptoms in …
Xiaoyao Kangai Jieyu Fang, a Chinese Herbal Formulation, Ameliorates Cancer-Related Depression Concurrent with Breast Cancer in Mice via Promoting Hippocampal Synaptic Plasticity.
Meng P, Han Y, Yang Q, Yang H, Zhu Q, Lin X, Zhang X, Zhao H, Liu Z, Liu J, Tang L, Luo W, Wang Y. Meng P, et al. Evid Based Complement Alternat Med. 2018 Nov 18;2018:3967642. doi: 10.1155/2018/3967642. eCollection 2018. Evid Based Complement Alternat Med. 2018. PMID: 30581482 Free PMC article.
Diagnosis with breast cancer is a major life event that elicits increases in depressive symptoms for up to 50% of women. Xiaoyao Kangai Jieyu Fang (XYKAJY) is derived from a canonical TCM formula, Xiaoyao San (XYS), which has a history of nearly 1000 years for treat …
Diagnosis with breast cancer is a major life event that elicits increases in depressive symptoms for up to 50% of women. Xiaoyao Kang …
Comprehensive multicomponent characterization and quality assessment of Xiaoyao Wan by UPLC-Q-Orbitrap-MS, HS-SPME-GC-MS and HS-GC-IMS.
Yin J, Wu T, Zhu B, Cui P, Zhang Y, Chen X, Ding H, Han L, Bie S, Li F, Song X, Yu H, Li Z. Yin J, et al. J Pharm Biomed Anal. 2024 Feb 15;239:115910. doi: 10.1016/j.jpba.2023.115910. Epub 2023 Dec 13. J Pharm Biomed Anal. 2024. PMID: 38101240
Xiaoyao Wan (XYW) is a prescription medicine of traditional Chinese medicine (TCM) with the effects of "soothing the liver and relieving depression," and "strengthening spleen and nourishing blood". ...
Xiaoyao Wan (XYW) is a prescription medicine of traditional Chinese medicine (TCM) with the effects of "soothing the liver and reliev …
[Therapeutic effect and mechanism of Xiaoyao Kangai Jieyu Recipe on mice with breast cancer related depression through regulating COX pathway].
He Y, Zou MS, Ren TT, Li P, Liu Y, Han YS. He Y, et al. Zhongguo Zhong Yao Za Zhi. 2023 Jul;48(14):3874-3881. doi: 10.19540/j.cnki.cjcmm.20230224.408. Zhongguo Zhong Yao Za Zhi. 2023. PMID: 37475079 Chinese.
This study aimed to investigate the intervention effect and mechanism of Xiaoyao Kangai Jieyu Recipe(XKJR) on hip-pocampal microglia and neuronal damage in mice with breast cancer related depression. ...
This study aimed to investigate the intervention effect and mechanism of Xiaoyao Kangai Jieyu Recipe(XKJR) on hip-pocampal microglia …
Quercetin Alleviates the Progression of Breast Cancer-Related Depression via Inhibiting the Pyroptosis and Promoting the Immune Response.
Zhu Q, Yang L, Yang H, Han Y, Chen Y, He Y. Zhu Q, et al. Mediators Inflamm. 2022 Mar 3;2022:8011988. doi: 10.1155/2022/8011988. eCollection 2022. Mediators Inflamm. 2022. PMID: 35369029 Free PMC article.
BACKGROUND: Breast cancer-related depression (BCRD) seriously inhibits the life quality of patients with breast cancer. The Xiaoyao Kangai Jieyu Formula is known to inhibit the progression of depression. However, the detailed function of the Xiaoyao Kangai Jieyu For …
BACKGROUND: Breast cancer-related depression (BCRD) seriously inhibits the life quality of patients with breast cancer. The Xiaoyao K …
Effects of Xiaoyao San on exercise capacity and liver mitochondrial metabolomics in rat depression model.
Zhao W, Ji C, Zheng J, Zhou S, Tian J, Han Y, Qin X. Zhao W, et al. Chin Herb Med. 2023 Dec 1;16(1):132-142. doi: 10.1016/j.chmed.2023.09.004. eCollection 2024 Jan. Chin Herb Med. 2023. PMID: 38375048 Free PMC article.
OBJECTIVE: This study aimed to investigate the therapeutic effects of Xiaoyao San (XYS), a herbal medicine formula, on exercise capacity and liver mitochondrial metabolomics in a rat model of depression induced by chronic unpredictable mild stress (CUMS). ...
OBJECTIVE: This study aimed to investigate the therapeutic effects of Xiaoyao San (XYS), a herbal medicine formula, on exercise capac …
Jiawei Xiaoyao capsule treatment for mild to moderate major depression with anxiety symptoms: a randomized, double-blind, double-dummy, controlled, multicenter, parallel-treatment trial.
Su R, Fan J, Li T, Cao X, Zhou J, Han Z, Ma Y. Su R, et al. J Tradit Chin Med. 2019 Jun;39(3):410-417. J Tradit Chin Med. 2019. PMID: 32186013 Free article. Clinical Trial.
OBJECTIVE: To assess the efficacy and safety of Jiawei Xiaoyao (JWXY) capsules on mild to moderate depression with anxiety symptoms, a randomized, double-blind, double-dummy controlled, multicenter, parallel-treatment trial was carried out among 210 outpatients with mild t …
OBJECTIVE: To assess the efficacy and safety of Jiawei Xiaoyao (JWXY) capsules on mild to moderate depression with anxiety symptoms, …
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