[Study on optimization of the hydrolysis process of dioscin catalyzed by hydrochloric acid]

Zhong Yao Cai. 2008 Jul;31(7):1059-62.
[Article in Chinese]

Abstract

Objective: To study the optimization of hydrolysis process of dioscin catalyzed by hydrochloric acid.

Methods: The effects of hydrochloric acid concentration, reaction temperature, reaction time and their interactions had been investigated using orthogonal design and single-factor experiments.

Results: The optimum hydrolysis conditions were as follows: reaction temperature 90 degrees C, reaction time 3h, hydrochloric acid concentration 2.0 mol/L.

Conclusion: Hydrochloric acid concentration and reaction temperature should be controlled because of their remarkable influence on hydrolysis process.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Catalysis
  • Dioscorea / chemistry*
  • Diosgenin / isolation & purification*
  • Drugs, Chinese Herbal / isolation & purification*
  • Hydrochloric Acid / chemistry*
  • Hydrolysis
  • Rhizome / chemistry
  • Technology, Pharmaceutical / methods*
  • Temperature
  • Time Factors

Substances

  • Drugs, Chinese Herbal
  • Diosgenin
  • Hydrochloric Acid